Sperm Mar Test

Sperm Mar Test

SPERM MAR TEST

Dr. Himanshu Roy | Srijan Fertility Clinic Pvt. Ltd. | IVF Center in India SPERM MAR TEST

Opening Hours : Mon to Sat - 9am to 6pm Contact : srijanfertilityclinic@gmail.com
The acronym MAR stands for mixed antiglobulin reaction. The test is used to diagnose imunological infertility, which means that antisperm antibodies are present that prevent conception from taking place. Antibodies in blood, semen or cervical mucous coat the surface of the sperm, which impairs sperm transport and ultimately fertilisation of the ovum. A diagnosis of imunological infertility is probable when 50% or more of the mobile sperm have antibody attached to them. However it is still possible to conceive assuming that there are no other abnormalities within the semen. Steroids may be helpful by lowering antibody levels and temporarily increasing the odds of conception occurring. Intra-uterine insemination is another treatment option that can be attempted. This involves the insertion of specially prepared sperm in the uterus having previously given medication to the female partner to induce ovulation or egg release. IVF is a further method that has also been successfully used to overcome the difficulties of antisperm antibodies being present. Therefore it is possible to conceive despite the presence of these antibodies but this is unlikely to happen without the assistance of modern reproductive technology.
You should avoid sexual intercourses, alcohol and excessive heat 2-5 days before the test.
The sperm is collected after masturbation and put in special glass containers. In the laboratory, our researcher will mix it with a special antiserum. If the sperm contains antibodies they will react with this serum forming an “antigen-antibody” interaction. Our specialist can see it through a microscope.
If there are just a few antibodies, this is considered a relative norm. When only 10-30% of gametes are attacked, the situation is not critical. Conception is still possible because the rest of sperm is still ready for fertilization.
If more than 50% of sperm is covered with antibodies, the MAR-test result will be positive. It means that a man has come across immunologic infertility. Though it is not very easy to overcome, our doctors can still treat it successfully.
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SpermMar test for detecting antisperm antibodies
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SpermMar test for detecting antisperm antibodies

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The SpermMar test is a test that is performed on a regular basis at Andrology labs for detecting the presence of antisperm antibodies in the semen.
It works by mixing latex particles to specific antibodies that are linked to sperm cells. When the result is a positive one, the sperms appear agglutinated with the latex particles. If there were no antisperm antibodies, the particles would remain isolated in the semen, and no agglutination would be observed.
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When more than 40% of motile spermatozoa present ASA of the IgG class, complementary testing for IgA antibodies is advisable

SpermMar Test IgA and SpermMar Test IgG are rapid, easy-to-use tests for the detection of anti-sperm antibodies in semen and serum.
Anti sperm antibodies (ASA) are produced when the blood-testis barrier is disrupted by obstruction, infection or traumatism. Immunoglobulines of the IgG class are usually present in both serum and semen, and the IgG antibodies attach to the spermatozoa. ASA of the IgA class are secreted by the accessory sex glands and are found in semen only. ASA of the IgG class may be detected in seminal plasma, but there is usually no free IgA in seminal plasma. Anti sperm antibodies of the IgA class almost never occur without IgG antibodies.
When more than 40% of motile spermatozoa present ASA of the IgG class, complementary testing for IgA antibodies is advisable
The immunological factor reduces the probability of spontaneous conception, and this is particularly true when ASA of the IgA class are also present.
SpermMar Test IgA has a 12 month shelf life from production date. Information about the composition of the product can be found in the material safety data sheet.
Europe: CE-marked – USA: registered – Canada: Health Canada licence
Brazil: registered – Australia: registered
SPMA_S : SpermMar Test IgA – Single kit – 50 tests
SPMA_C : SpermMar Test IgA – Complete kit – 50 tests
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A: This condition is also known as 'sperm allergy.' The immune system of some men and women see sperm as a foreign invader, like a germ, and their bodies make antibodies to attack and destroy the sperm. These antibodies can be directed against sperm surface antigens and have a negative effect on fertility. They can attach to the surface of the sperm, impair different functions of the sperm, and increase the risk of destruction of the sperm by the immune system.
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