Sperm Farming

Sperm Farming

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While we mostly focus on female fertility, in this post we’re going to take a look at male reproductive health and, in particular, sperm production. In fact, knowing the sperm life cycle is actually really important for also understanding the female fertile window, and for understanding fertility more widely. Read on to find out more...
A crucial, and often difficult, difference between female and male fertility is time. While female fertility is limited to a number of years, men are fertile for most of their adult life. One of the reasons for this is that women are born with all of their egg cells and the quality of these decreases with age. On the other hand, sperm are continuously produced, with approximately 100 million made each day! So how does sperm production work? What is the process? How long does it take? And what does this mean for men wanting to improve their sperm sample quality?
Semen is another word for ejaculate - the fluid which is expelled from the penis during sexual climax. But what is semen made of? Firstly, ejaculate is made up of two components: The sperm, which comes from the testicles, and the seminal fluid, which is produced in other organs, including the prostate. These two components are mixed during ejaculation, creating semen. Today we’ll focus on sperm production in the testicles, a process scientifically called spermatogenesis.
Although the testicles appear externally to be round structures, they’re actually made up of lots of tightly coiled tubules as you can see in the diagram below. Within the walls of these tubules, the sperm cells are produced and then matured.
Spermatogenesis (sperm cell production) takes on average 64 days from start to finish, but this varies between individuals. Immature sperm cells will divide multiple times within the testes resulting in the production of the tadpoles like cells we recognise as sperm.
This immature but structurally complete sperm cell consists of a head, midpiece, and tail. The head contains the genetic information (DNA) of the male, the midpiece contains cells to produce energy for swimming and the tail enables swimming once the sperm has matured and is ejaculated. Finally, the sperm passes into the epididymis, which acts as a sort of holding bay, where the sperm can continue to mature and gain the ability to swim. It’s here that they are also fine-tuned for the possibility of meeting the female egg cell in the future.
So having learned about the process of sperm production, how is this information useful for couples wanting to conceive? Well firstly, this process takes two and half to three months. That means that if you are wanting to improve the quality of your ejaculate, you’ll need to make dietary and lifestyle changes in advance of when you want to make the most of the ejaculated sample!
Eating a balanced diet and exercising regularly can help to improve sperm quality. For many men, simply eating a healthy range of foods will provide the right nutrients to make sure sperm production is optimal. Although many millions of sperm are produced each day, the majority of these, once ejaculated into the vagina during sex, will not reach the egg. So while it may sound like a lot of sperm cells are being produced, in reality, these have a quite few hurdles to overcome on their epic journey through the female reproductive tract.
Remember that just like the varying pattern of the female menstrual cycle , semen quality in men is individualised and may change from month to month. It is quite normal for the quality of one man's ejaculate to increase and decrease over time, but maintaining a healthy diet and lifestyle will help set good foundations for sperm production.
If you have not been able to conceive after twelve months of unprotected sex, talk to your healthcare professional and they can begin looking into whether there may be some issues with sperm quality.
We hope you’ve enjoyed learning all about sperm production. Remember, the fertility journey is different for every couple. While both male and female fertility have roles to play, women are only fertile for six days in any menstrual cycle.
Natural Cycles is a method combining an app and a thermometer, that helps women predict and confirm ovulation, meaning couples can find that fertile window and plan pregnancy with precision . Are you ready to learn more about your fertility?
With 10 years of experience working in the field of fertility, Dr. Jack Pearson is Natural Cycles’ in-house expert. As Medical Affairs Manager, he dedicates his time to conducting groundbreaking research and educating healthcare professionals.
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Figure 1. The hormone axis that controls sperm production. T=Testosterone.
Figure 2. The male reproductive tract. From Netter, with permission.

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Sperm production is hormonally driven . Brain hormones govern sperm production and are precisely controlled. The male genitalia are responsible for sperm and ejaculate production . Within the brain, the hypothalamus and anterior pituitary control sperm production . The hypothalamus secretes gonadotropin-releasing hormone (GnRH), which acts on the anterior pituitary gland, stimulating it to release follicle stimulating hormone (FSH) and leutinizing hormone (LH). FSH and LH are released into the bloodstream and act only on the testes to encourage spermatogenesis within seminiferous tubules (action of FSH) and testosterone production by neighboring Leydig cells (action of LH) between the seminiferous tubules (Figure 1). Normal hormone balance is important for normal sperm production and these hormones are often measured as part of the infertility evaluation.
The male genitalia consist of the scrotum, which houses the testicles and associated ducts (the epididymis and vas deferens), and the penis (Figure 2). The testes are covered by a tough, white, fibrous layer called the tunica albuginea, which extends inward and divides the testis into 200 to 300 lobules. Sperm production occurs in the long and tightly coiled seminiferous tubules that are located in each of these lobules. Sertoli cells line the seminiferous tubules and serve as nurse cells to provide essential nutrients to sperm. In the absence of spermatogenesis, only Sertoli cells are seen on microscopic inspection of a testicular biopsy . Another important cell type within the testis are Leydig cells, which make testosterone , the essential male hormone. Testosterone is responsible for normal male secondary sex characteristic development, libido or sex drive and normal erections. Testosterone is also important for sperm production, as levels of this hormone are 50 fold higher within the testis as in the blood.
Within the adult testicle, there is 700 feet of tubing, termed seminiferous tubules, within which sperm is made. Sperm is made from precursor cells termed germ cells that give rise to approximately 120 million sperm daily in a process termed spermatogenesis that takes approximately 64 days in humans. This is equivalent to making about 1200 sperm per heartbeat. Within the seminiferous tubule, germ cells are arranged in a highly ordered sequence from outside to inside. Lining the tubules, there are adult testis stem cells that begin the process of sperm production. Overall there are 13 recognizable germ cell types in the human testis: dark type A spermatogonia (Ad); pale type A spermatogonia (Ap); type B spermatogonia (B); preleptotene (R), leptotene (L), zygotene (z) and pachytene primary spermatocytes (p); secondary spermatocytes (II); and Sa, Sb, Sc, Sd1, and Sd2 spermatids. Despite the high volume production of sperm, quality control checkpoints exist throughout the sperm production process to ensure the biological and genetic integrity of ejaculated sperm.
It has long been believed that sperm take 90 days (3 months) to be made and ejaculated. Dr. Turek recently discovered and published that in fact this time frame is actually much shorter. Sperm develop in the testicles for 50-60 days and are then excreted into the coiled ducts of the epididymis and complete their maturation for another 14 days . Sperm waiting to be ejaculated remain in the epididymis, near the bottom of the scrotum. At ejaculation, sperm are propelled through the vas deferens within the spermatic cord and into the abdominal cavity and join the seminal vesicles, which add alkaline fluid that helps to support sperm. The ejaculate consists of fluid from 3 sources: the vas deferens (sperm fraction), the seminal vesicles, and the prostate. The seminal vesicle fluid makes 80% of the total semen volume, the vas deferens 10% and the prostate gland another 10%. This mixture of semen then exits the penis during ejaculation.
The spermatozoon is a remarkably complex metabolic, locomotive and genetic machine. It is approximately 60 microns in length and is divided into 3 sections: head, neck and tail. The oval sperm head consists of a nucleus containing the highly compacted DNA, and an acrosome that contains the enzymes required for penetration of the egg shell for fertilization. The neck maintains the connection between the sperm head and tail and consists of the connecting piece and proximal centriole. The tail harbors the midpiece, principle piece and endpiece. The tail midpiece contains the axoneme or engine of the sperm and the mitochondrial sheath, the source of energy for movement. Physiologically, the sperm axoneme is the true motor assembly and requires 200-300 proteins to function. Among these, the microtubules are the best-understood components. Sperm microtubules are arranged in the classic “9+2” pattern of 9 outer doublets encircling an inner central doublet. Defects in the sperm axoneme are well-recognized causes of ciliary dyskinesias that are routinely associated with infertility.
Award-winning urologist and men’s health pioneer Dr. Paul Turek authors Turek on Men’s Health, named one of Healthline’s top men’s health blogs (2016 to present) and one of the Top 30 Men’s Health Blogs (2017). The blog covers the gamut of men’s health issues, from infertility to hormones to vasectomy reversal.
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2998 S Bascom Ave
San Jose, CA 95124
Phone: 1-888-TUREKMD
Facsimile: 415-392-3201
Facsimile (patient records only):
415-392-3268
9033 Wilshire Blvd., Suite 408
Beverly Hills, CA 90211
Phone: 310-499-9299
Facsimile: 415-392-3201
Facsimile (patient records only):
415-392-3268
450 Sutter St, Ste 1708
San Francisco, CA 94108
Phone: 415-392-3200
Facsimile: 415-392-3201
Facsimile (patient records only):
415-392-3268
2998 S Bascom Ave
San Jose, CA 95124
Phone: 1-888-TUREKMD
Facsimile: 415-392-3201
Facsimile (patient records only):
415-392-3268

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