Sorla Sekx
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Sorting-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs cargo proteins, such as kinases, phosphatases, and signaling receptors, to their correct location within the cell. The activity of SORLA assures proper function of cells and tissues, and receptor d …
Abstract sorLA (Sorting protein-related receptor) is a type-1 membrane protein of unknown function that is expressed in neurons. Its homology to sorting receptors that shuttle between the plasma membrane, endosomes, and the Golgi suggests a related function in neuronal trafficking processes.
Abstract Sorting-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs cargo proteins, such as kinases, phosphatases, and sig-naling receptors, to their correct location within the cell. The activity of SORLA assures proper function of cells and tissues, and receptor dysfunction is the underlying cause of common human malignancies, including Alz-heimer ...
The sortilin-related receptor SORLA is an endocytic receptor that belongs to the vacuolar protein sorting 10 (VPS10) domain receptor family. SORLA binds to the amyloid precursor protein (APP). It functions as an intracellular sorting receptor as APP is being trafficked between the secretory pathway, the cell surface, and, subsequently, endosomes. SORLA is localized primarily to the trans-Golgi ...
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This suggests that the direct or indirect interaction of SORLA with HER2 and SORLA sorting functions are both necessary for SORLA-mediated proliferation of HER2-dependent cancer cells.
Specifically, SORLA facilitates functional expression of the insulin receptor (IR) to promote insulin-dependent suppression of lipolysis in adipocytes. Overexpression of SORLA in adipose tissue blocks hydrolysis of triacylglycerides to free fatty acids (FFAs) and enhances fat deposition.
21 апр. 2025 г.
Sorla is a rare feminine given name most commonly analyzed as a modern variant or Anglicized shortening of the Old Norse Sólrún or Sigríðr-derived forms, and it often appears connected to the Gaelic-Scandinavian blend seen in the Hebrides and Isle of Man.
Here, we demonstrate a previously undescribed role for SORLA in enhancing neurite outgrowth and regeneration. Transgenic neurons overexpressing SORLA (SORLA TG) and neurons exposed to the purified sSORLA ectodomain show increased neurite extension and accelerated neurite regeneration following wound injury in culture.
Sortilin, also known as Neurotensin Receptor-3, and the sorting-related receptor with type-A repeats (SorLA) are both members of the Vps10p domain receptor family. Initially identified in CNS cells, they are expressed in various other cell types ...
SORLA is a transmembrane trafficking protein associated with Alzheimer's disease risk. Although SORLA is abundantly expressed in neurons, physiological roles for SORLA remain unclear. Here, we show that cultured transgenic neurons overexpressing SORLA feature longer neurites, and accelerated neurite regeneration with wounding. Enhanced release of a soluble form of SORLA (sSORLA) is observed in ...
Sorla Khan is an Oglodi. She replaced Axe as the leader of the Red Mist army, and is known for being violent and unreasonable, even for an Oglodi.[1][2] Donte Panlin has battled Sorla before with unclear results.[3] Yurnero is concerned about her actions, and wants to discuss a solution with Axe.[4] Sorla is currently hunting for Axe, possibly for what he did earlier to the Red Mist Army. When ...
SORL1 (also known as SORLA, SORLA1, or LR11; SORLA or SORL1 are used, often interchangeably, for the protein product of the SORL1 gene) is a 2214 residue type I transmembrane protein receptor that binds certain peptides and integral membrane protein cargo in the endolysosomal pathway and delivers them for sorting to the retromer multi protein ...
Sortilinrelated receptor (SorLA) is a sorting receptor mainly investigated with regard to neuronal and metabolic diseases. We discovered oncogenic properties of SorLA through supporting HER2 and HER3 expression and signaling, thus mediating cancer response to growth factors to promote HER2-therapy resistance.
SORLA is unique among the members of the VPS10P domain receptor gene family as it contains additional functional modules not shared by the other receptors including domains for protein-protein ...
SORLA-driven endosomal trafficking regul ates the oncogenic fitness of HER2 Mika Pietilä 1,*,#, Pranshu Sahgal1,*, Emilia Peuhu1, Niklas Jäntti1, Ilkka Paatero1, Olav M.
Detail from the Stora Hammars I stone, an image stone on Gotland Detail from the Smiss (I) stone, an image stone on Gotland Sörla þáttr eða Heðins saga ok Högna is a short narrative from the extended version Óláfs saga Tryggvasonar en mesta [1] found in the Flateyjarbók manuscript, [2] which was written and compiled by two Christian priests, Jon Thordson and Magnus Thorhalson, [3] in ...
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Impaired SorLA maturation and tra cking as a new mechanism for SORL1 missense variants in Alzheimer disease
Here, we report that the endocytic receptor SorLA targets IL-6 and IL-6R. We present evidence that SorLA mediates efficient cellular uptake of both IL-6 and the circulating IL-6R in astrocytes. We further show that SorLA interacts with the membrane-bound IL-6R at the cell surface and thereby downregulates IL-6 cis signaling.
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1.2 SORLA impacts vascular integrity and promotes atherosclerosis SORLA is a 250 kDa receptor that harbors a VPS10P domain but also displays structural elements found in the LDLR and other members of the LDLR gene family (such as a β-propeller and complement-type repeats). The encoding gene had been mapped as a pro-atherogenic locus in inbred strains of mice [16]. The relevance of SORLA for ...
Abstract The brain`s homeostasis depends heavily on the integrity of the blood-brain barrier (BBB). Astrocytes are an essential part of the BBB in modulating and maintaining the barrier properties of the brain endothelial cells (BECs). Despite decades of research, the elements of glial regulation are not fully elucidated. SorLA/SorL1/LR11, a multifunctional receptor, is the most composite ...
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Background: The mammalian Vps10p sorting receptor family is a group of 5 type I membrane homologs (Sortilin, SorLA, and SorCS1-3). These receptors bind various cargo proteins via their luminal Vps10p domains and have been shown to mediate a variety of intracellular sorting and trafficking functions. These proteins are highly expressed in the brain. SorLA has been shown to be down regulated in ...
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Sorla Khan is an Oglodi. She replaced Axe as the leader of the Red Mist army, and is known for being violent and unreasonable, even for an Oglodi.
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SorLA Vps10p domain in ligand-free form SorLA is a neuronal sorting receptor considered to be a major risk factor for Alzheimer's disease. We have recently reported that it directs lysosomal targeting of nascent neurotoxic amyloid-β (Aβ) peptides by directly binding Aβ. Here, we determined the crystal structure of the human sorLA domain responsible for Aβ capture, Vps10p, in an unbound ...
sorl a uttal: så:rla ˈsoːrˌla (om vatten) åstadkomma ett oregelbundet, brusande ljud 1856: Hertha, Fredrika Bremer: En klar källa sprang sorlande upp nära vid det höga trädets fot. Synonymer: brusa, porla (om personer) åstadkomma ett kontinuerligt ljud av många röster som blandas samman På gatan sorlar folkmassan som med anspänning väntar på dess store ledare. Synonymer: stimma ...
Sorla (Hydraxis) Immoral Wombats - 80 Dark Iron Dwarf Discipline Priest, 559 ilvl
Fun fact: Sorla's first ninjago appearance was not in the ice chapter but in "The explorers club", she is one of the clokes that Zane used (others being Clutch Powers and a girl from a commercial).
Oblivion Mod:Order of the Dragon/Sorla's Past The UESPWiki - Your source for The Elder Scrolls, in memory of Julian LeFay < Mod / Oblivion: Oblivion Mod: Order of the Dragon: Quests ⧼monobook-jumptonavigation⧽ ⧼monobook-jumptosearch⧽
Here, we find that sortilin-related receptor 1 (SORLA; SORL1) co-precipitates with HER2 in cancer cells and regulates HER2 subcellular distribution by promoting recycling of the endosomal receptor back to the plasma membrane. SORLA protein levels in cancer cell lines and bladder cancers correlates with HER2 levels.
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Sorting-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs cargo proteins, such as kinases, phosphatases, and signaling receptors, to their correct ...
10 сент. 2025 г.
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Sortilin and SorLA are members of the Vps10p domain receptor family, the Sortilins, which comprise five type I transmembrane receptors differentially expressed in neuronal tissues of the central and peripheral nervous system. Since the identification of sortilin in 1997, members of this receptor family are recognized as sorting receptors primarily in the trans-Golgi network, interacting with a ...
Sortilin, also known as Neurotensin Receptor-3, and the sorting-related receptor with type-A repeats (SorLA) are both members of the Vps10p domain receptor f...
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19 февр. 2024 г.
Here, we report that the endocytic receptor SorLA targets IL-6 and IL-6R. We present evidence that SorLA mediates efficient cellular uptake of both IL-6 and the circulating IL-6R in astrocytes. We further show that SorLA interacts with the membrane-bound IL-6R at the cell surface and thereby downregulates IL-6 cis signaling.
Sortilin, also known as Neurotensin Receptor-3, and the sorting-related receptor with type-A repeats (SorLA) are both members of the Vps10p domain receptor family. Initially identified in CNS cells, they are expressed in various other cell types where they exert multiple functions. Although mostly s …
The family of mammalian type-I transmembrane receptors containing a Vps10p domain contains five members, Sortilin, SorCS1, SorCS2, SorCS3, and SorLA. The common characteristic of these receptors is an N-terminal Vps10p domain, which either represents the only module of the luminal/extracellular moiety or is combined with additional domains. Family members play roles in protein transport and ...
Here, we describe the functional elucidation of a new sorting receptor SORLA that emerges as a central regulator of trafficking and processing of APP. SORLA interacts with distinct sets of cytosolic adaptors for anterograde and retrograde movement of APP between the trans-Golgi network and early endosomes, thereby restricting delivery of the ...
Abstract SORLA is a sorting receptor known to control the intracellular trafficking of the amyloid precursor protein, which impaired pathway has a central role in the development of Alzheimer's disease (AD). Recently, genetic analyses confirmed the casual role for SORLA in AD, as coding variants and single nucleotide polymorphisms of SORL1 (gene encoding SORLA) were identified in individuals ...
5 дн. назад
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