Sorla Borno
Sorla Borno
SORL1 (also known as SORLA, SORLA1, or LR11; SORLA or SORL1 are used, often interchangeably, for the protein product of the SORL1 gene) is a 2214 residue type I transmembrane protein receptor that binds certain peptides and integral membrane protein cargo in the endolysosomal pathway and delivers them for sorting to the retromer multi protein ...
The SORL1 gene encodes the sortilin-related receptor protein SORLA, a sorting receptor that regulates endo-lysosomal trafficking of various substrates. Loss of function variants in SORL1 are causative for Alzheimer's disease (AD) and decreased expression of SORLA has been repeatedly observed in huma …
INTRODUCTION Mutations in SORL1, encoding the sorting receptor Sortilin-related receptor with A-type repeats (SORLA), are found in individuals with Alzheimer's disease (AD). We studied SORLA N1358S, carrying a mutation in its ligand binding domain, to learn more about receptor functions relevant for human brain health. METHODS We investigated consequences of SORLA N1358S expression in induced ...
SORL1 /SORLA is a sorting receptor involved in retromer-related endosomal traffic and an Alzheimer's disease (AD) risk gene. Using CRISPR-Cas9, we deplete SORL1 in hiPSCs to ask if loss of SORL1 contributes to AD pathogenesis by endosome dysfunction. SORL1 -deficient hiPSC neurons show early endosome enlargement, a hallmark cytopathology of AD. There is no effect of SORL1 depletion on ...
The sortilin-related receptor SORLA is an endocytic receptor that belongs to the vacuolar protein sorting 10 (VPS10) domain receptor family. SORLA binds to the amyloid precursor protein (APP). It functions as an intracellular sorting receptor as APP is being trafficked between the secretory pathway, the cell surface, and, subsequently, endosomes. SORLA is localized primarily to the trans-Golgi ...
Ten years ago, Lah and colleagues reported that steady-state levels of the transmembrane protein SORLA (sorting protein-related receptor with A-type repeats, also called SORL1 or LR11) were markedly reduced in vulnerable brain regions of individuals afflicted with late-onset Alzheimer's disease (AD) (1). Since then, genetic and cellular biological evidence has emerged to detail how changes ...
Background The SorLA protein, encoded by the Sortilin-related receptor 1 (SORL1) gene, is a major player in Alzheimer's disease (AD) pathophysiology. Functional studies demonstrated that SorLA deficiency results in increased production of Aβ peptide, and thus a higher risk of AD. SorLA can be subject to proteolytic shedding at the cell surface, leading to the release of the soluble ...
SORLA is a transmembrane trafficking protein associated with Alzheimer's disease risk. Although SORLA is abundantly expressed in neurons, physiological roles for SORLA remain unclear. Here, we show that cultured transgenic neurons overexpressing SORLA feature longer neurites, and accelerated neurite regeneration with wounding. Enhanced release of a soluble form of SORLA (sSORLA) is observed in ...
SORLA is known to interact with the endosomal trafficking regulatory complex called retromer in regulating the recycling of endosomal cargo, including the amyloid precursor protein (APP) and the glutamate receptor GluA1. Nevertheless, SORLA's precise structural-functional relationship in endosomal recycling tubules remains unknown.
In this work, we selected eight high-affinity Nbs from a library generated against the entire ectodomain of SORLA. Using a panel of SORLA deletion constructs, we have performed an epitope mapping analysis of the first ever developed SORLA-specific Nbs.
BOGIS on Wednesday unveiled an advanced automated application portal for land documentation and acquisition by individuals in Borno.
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The Nigerian Air Force says it has destroyed some solar panel jets owned by Boko Haram in Gamboru-Ngala in Borno state. A statement signed...
The European Union funded solar micro grid systems that targets to improve the wellbeing of communities in Borno State with rural electrification as part of its support in response to recovery, resettlement and resilience will be launched tomorrow 6th July 2021. Following this project, lives are ...
By 'Kunle ADEBAJO. POPULAR Twitter account Africa Facts Zone repeated a widespread claim in August 2019 that Nigeria's Borno State has the "biggest" solar panel factory in Africa. In April 2019, the state's former governor, Kashim Shettima, unveiled an automated solar panel manufacturing plant in the state. Shettima left office in May 2019. "It is Africa's biggest and is fully […]
The Borno government has established Africa's largest solar panel factory (SOPF) to overcome challenges of power outage in Maiduguri. The fully-automated plant sited at Njimtilo village is to produce 40 megawatts worth of panels yearly to overcome the menace. The Honourary Special Adviser on Agriculture, Ibrahim Ali, disclosed this yesterday in Maiduguri while test-running the plant. He said ...
Borno State Governor, Babagana Umara Zulum, on Friday unveiled a 90-horsepower capacity solar irrigation pump station in Damasak, located in the northern part of the state, to boost food security.
POPULAR Twitter account Africa Facts Zone repeated a widespread claim in August 2019 that Nigeria's Borno State has the "biggest" solar panel factory in Africa. In April 2019, the state's former governor, Kashim Shettima, unveiled an automated solar panel manufacturing plant in the state ...
Popular Twitter account Africa Facts Zone repeated a widespread claim in August 2019 that Nigeria's Borno state has the "biggest" solar panel factory in Africa. In April 2019, the state's former governor, Kashim Shettima, unveiled an automated solar panel manufacturing plant in the state ...
Despite Billions Allocated, Borno Industrial Hub Remains Abandoned 5 Years After The Borno State solar panel plant and industrial hub, commissioned in 2019, remains locked despite huge expenses and ambitious promises. The project's objectives of creating job opportunities and stimulating economic growth have become a distant dream.
By Ndahi Marama, Maiduguri The World Bank Mission in partnership with the Federal Government through the Rural Electrification Agency (REA) is to spend $750 million to provide Solar energy to ...
The Borno government has established Africa's largest solar panel factory (SOPF) to overcome challenges of power outage in Maiduguri. The fully-automated plant sited at Njimtilo village is to ...
Borno State, located in the semi-arid region of Nigeria, has long depended on agriculture as a primary source of livelihood. However, climate change is drastically altering the landscape, with significant consequences for farmers, herders, and the overall food security of the region.
Reader for Issuu June 04, (THEWILL) - As part of efforts to ensure access to clean water, the United Nations Children's Fund (UNICEF) has handed over six solar-powered boreholes to the Borno state government. The borehole projects, which spread across Maiduguri Metropolitan Council and Jere, aims to provide 12,000 people access to clean water. Speaking during the handing over ceremony in ...
The Borno State Government said it has concluded all arrangements to inaugurate reputedly Africa's largest Solar Panel Factory (ASPF), to overcome challenges of power outages in the State. The ...
By Mohamed Aisha As part of its civil-military relations efforts, the Nigerian Navy has donated industrial solar-powered boreholes to alleviate water scarcity in Lassa Community, Askira Uba Local Government Area of Borno State. The 80,000-liter solar-powered motorized industrial boreholes and 80,000-liter overhead water supply system were facilitated by a community member, Rear Admiral Samson ...
The Borno State Government has completed and unveiled the largest solar panel factory in the country and Africa at large. The solar factory, which is located at Jimtilo Village, is said to be fully automated and has the capacity to produce 40 Megawatts worth of panels per year, with each panel having 300 watts capacity.
The Food and Agriculture Organization of the United Nations (FAO) invites you to submit a bid (ITB Nr 2025/FRNIR/FRNIR/134178 - Construction of Solar-Powered Boreholes and Accessories for Dry Season Farming in Borno, Yobe, and Adamawa States If you are interested in submitting an offer, please ensure you have at least a UNGM Basic ...
The Nigeria National Petroleum Corporation, NNPC and Shell Exploration and Production Company have donated 10 Solar Powered Boreholes and 16 VIP latrines to thousands of Internally Displaced ...
Sorting-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs cargo proteins, such as kinases, phosphatases, and signaling receptors, to their correct location within the cell. The activity of SORLA assures proper function of cells and tissues, and receptor dysfunction is the underlying cause of common human malignancies, including Alzheimer's disease ...
The Borno Model draws inspiration from the United Nations-backed initiatives in Sierra Leone and Liberia, which were introduced to curb widespread violence in those countries. Similarly, the Borno Model has gained international recognition, leading to the signing of a Memorandum of Understanding (MoU) for UN support in managing the mass surrender.
The Borno State Government has completed and unveiled the largest solar panel factory in the country and Africa at large. The solar factory, which is located at Jimtilo Village, is said to be fully automated and has the capacity to produce 40 Megawatts worth of panels per year, with each panel having 300 watts capacity.
Nine new European Union-funded projects aimed at building the resilience in conflict affected communities in Borno State will be launched in Maiduguri on Tuesday 23 January 2018 by the Governor, His Excellency Alhaji Kashim Shettima, at the Government House, Maiduguri.
Borno State Ministry For Reconstruction, Rehabilitation And Resettlement. 10,915 likes · 29 talking about this · 73,213 were here. This page is solely on activities of the Honourable Commissioner...
Looking for the comprehensive list of local government areas in Borno State? Check out our article for the full list with headquarters! All the info you need, right at your fingertips.
Get the latest Tenders and Contracts on Borno State Government/Inclusive Basic Service Delivery And Livelihood Empowerment Integrated Programme- Invitation To
Africa's Media Giant Borno: From ashes of insecurity to agric revolution By Hamza Suleiman, News Agency of Nigeria (NAN) Prior to the Boko Haram insurgency Borno was one of the most agriculturally advanced states in Nigeria with more than two-third of its population engaged in cereal crops, livestock, fishery, and poultry production. This contributed significantly to Nigeria's food supply ...
Maiduguri - The International Organization for Migration (IOM) has successfully completed the solarization of all nine UN humanitarian hubs in Borno State, Northeast Nigeria, marking a major milestone in the transition to sustainable and efficient energy solutions in humanitarian operations.
Find Professional Solar Panel Installers in Maiduguri, Borno. Get quotes and compare prices from verified Solar Panel Installers on VisCorner.
Dr Evans will use genetic engineering to investigate one of the proteins that regulates levels of amyloid in human brain cells.
In northeast Nigeria, the Food and Agriculture Organization of the United Nations is working to strengthen the agricultural response to climate change in the region, through promoting the Climate Smart Agriculture (CSA) approach in the conflict-affected states of Adamawa, Borno and Yobe.
Modeling and simulation of an active solar water heating system for Maiduguri, Borno State, Nigeria L Raji1, S Shodiya2, G M Ngala2 and M T Baba1 Published under licence by IOP Publishing Ltd IOP Conference Series: Materials Science and Engineering, Volume 912, Thermal Citation L Raji et al 2020 IOP Conf. Ser.: Mater. Sci.
Borno State Governor, Babagana Umara Zulum, recently introduced a solar irrigation pump station in Damasak, located in the northern part of the state.
Huang et al. show that the Alzheimer's disease (AD) risk factor SORLA inhibits amyloid β-induced synaptotoxicity and cognitive impairment through interacting with and subsequently inactivating EphA4. These findings provide a novel ...
Governor Babagana Umara Zulum of Borno State has called on the World Bank's Livestock Productivity and Resilience Support (LPRES) Project team to align their interventions with the specific needs and priorities of the people in the state.
1. The Federal Government of Nigeria has received financing from the World Bank toward the cost of the Livestock Productivity and Resilience Support (L-PRES)
Prior to the Boko Haram insurgency Borno was one of the most agriculturally advanced states in Nigeria with more than two-third of its population engaged in cereal crops, livestock, fishery, and ...
In this interview, Ali who is executing Governor Kashim Shettima's industrialisation policy speaks on the kick-off of the Borno Solar Panel Factory. What is the motive behind plans to unveil the Solar Power Panel Factory in Maiduguri?
Descubre el Libro Blanco de Otorrinolaringología 2025, presentado en el XXVII Congreso SORLA, con información clave sobre avances y perspectivas en la especialidad.
The project Implementation Unit, Inclusive Basic Service Delivery and Livelihood Empowerment Integrated Programme Borno State now invites sealed bids from eligible bidders for the execution of the works for the construction of 20 solar powered boreholes in Shani, Bayo, Gwoza and Askira Uba LGAs.
IHS Nigeria at the weekend donated four solar-powered boreholes to support victims of recent floods in Maiduguri, Borno State. The company is part of the IHS Holding Limited, one of the largest ...
The Borno State Government through The State Universal Basic Education Board in compliance with Public Procurement acts 2007 invites reputable and competent contractors to submit Pre-qualification / Tender documents for the Construction and Installation of Solar Power. Interested contractors should possess relevant qualifications and experience.
SORLA interacts with distinct sets of cytosolic adaptors for anterograde and retrograde movement of APP between the trans-Golgi network and early endosomes, thereby restricting delivery of the precursor to endocytic compartments that favor amyloidogenic breakdown.
Jutha Gupah, Maiduguri The Borno state government has established Africa's largest Solar Panel Factory (SOPF) overcome challenges of power outages in Maiduguri metropolis. The fully automated plant sited at Njimtilo village; will produce 40 megawatts worth of panels per annum to overcome challenges of power outages in the state. Honourary Special Adviser on Agriculture, Ibrahim […]
Children displaced across camps in Maiduguri, northeast Nigeria, six weeks after the flood, reflect on how the disaster has disrupted their lives.
Which upcoming lunar and solar eclipses are visible in Sama, Borno State, Nigeria, and what do they look like?
The Chief of Naval Staff, Vice Admiral Emmanuel Ikechukwu Ogalla on Thursday commission the newly constructed solar powered motorized industrial Borehole and 80,000 liter capacity overhead water su…
Discover how UNICEF's solar boreholes are improving health and access to clean water in Borno, tackling disease effectively.
Explore the verified history of the Borno Empire, tracing its origins from the Kanem Empire, the reign of Idris Alooma, the Kanemi revival, colonial integration, and its enduring cultural and religious significance in Nigeria.
SORLA acts as an endosome recycling receptor together with the retromer complex to escort cargo through the endo-lysosomal tubular network. SORLA is encoded by the SORL1 gene, which is the gene most frequently mutated in patients with Alzheimer's disease, although it is still not clear which of the many variants are (the most) pathogenic.
SORLA interacts with distinct sets of cytosolic adaptors for anterograde and retrograde movement of APP between the trans-Golgi network and early endosomes, thereby restricting delivery of the precursor to endocytic compartments that favor amyloidogenic breakdown.
Here, we find that sortilin-related receptor 1 (SORLA; SORL1) co-precipitates with HER2 in cancer cells and regulates HER2 subcellular distribution by promoting recycling of the endosomal receptor back to the plasma membrane. SORLA protein levels in cancer cell lines and bladder cancers correlates with HER2 levels.
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