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PTEN signaling in brain neuropathology and tumorigenesis

Pten haploinsufficiency causes desynchronized growth of brain

The Role of PTEN in Neurodevelopment PMC

Pten haploinsufficiency causes desynchronized growth of brain

Longitudinal neuroanatomical changes determined by

Disruptive lysosomalmetabolic signaling and

Pten Mutations Alter Brain Growth Trajectory and Allocation

Telencephalic neurocircuitry and synaptic plasticity in

Skilled forelimb movements and internal copy motor circuits

PDF Endersby R Baker SJ PTEN Signaling in Brain

Pten haploinsufficiency disrupts scaling across brain areas

Pten haploinsufficient mice show broad brain overgrowth but

Pten haploinsufficient mice show broad brain overgrowth but


24 sept. 2015 · Pten haploinsufficiency causes desynchronized growth of brain areas involved in sensory processing. 2024, iScience . Citation Excerpt : This task assesses spatial learning and memory; by including reversal learning, we also measure persev. 1 juil. 2014 · Widespread brain overgrowth together with selective behavioral impairments in Pten(+/-) mice raises the possibility that most brain areas and constituent cell types adapt to an altered trajectory of growth with minimal impact on the behaviors tested in our battery; however, select areas/cell types relevant to social behavior are more vulnerable or less adaptable, thus resulting in social. Pten haploinsufficiency causes desynchronized growth of brain areas involved in sensory processing Amy E. Clipperton-Allen,1 Hannah Swick,1 Valentina Botero,1,2 Massimiliano Aceti,1,5 Jacob Ellegood,3 Jason P. Lerch,3,4 and Damon T. Page1,2,6,* SUMMARY How changes in brain scaling relate to altered behavior is an important question. 15 juil. 2015 · We report that Pten haploinsufficiency leads to a dynamic trajectory of brain overgrowth during development and altered scaling of neuronal and glial cell populations. β-catenin signaling is elevated in the developing cerebral cortex of Pten haploinsufficient mice, and a heterozygous mutation in β-c. Haploinsufficiency for PTEN is a cause of autism spectrum disorder and brain overgrowth; however, it is not known if PTEN mutations disrupt scaling across brain areas during development. 19 janv. 2024 · Mice with germline Pten haploinsufficiency (Pten +/-) closely mirror the abnormal brain scaling and behavioral deficits seen in humans with macrocephaly/autism syndrome, which is caused by PTEN mutations. We explored whether deviation from normal patterns of growth can predict behavioral abnormalities. Brain regions associated with sensory. 18 févr. 2024 · When we looked at this deviation using absolute volume, we found that most brain regions were significantly larger than predicted by the Pten +/+ growth trajectory; out of 54 brain regions, only the cerebellar cortex and frontal lobe of the cerebral cortex did not show a significantly higher growth trajectory than predicted (see Figure 1 D. 18 sept. 2008 · PTEN signaling in brain: neuropathology and tumorigenesis. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor that antagonizes the phosphatidylinositol-3-kinase (PI3K)/Akt/mTOR pathway by functioning as a lipid phosphatase. 15 sept. 2008 · Mouse models based on Pten deletion in the brain have provided insights into the normal functions of Pten in the nervous system as well as the initiation and progression of gliomas. functions of Pten in the nervous system as well as the initiation and progression of gliomas. Compromised PTEN function may contribute to gliomagenesis through. 1 sept. 2008 · PTEN signaling in brain: neuropathology and tumorigenesis. - Abstract - Europe PMC Preprints in Europe PMC Europe PMC Funders' Group ; and in cooperation with the National Center for Biotechnology Information U.S. National Library of Medicine (NCBI/NLM) . It includes content provided to the. 1 oct. 2008 · PTEN Signaling in Brain: Neuropathology and Tumorigenesis. Oncogene (in press) DOI: 10.1038/onc.2008.239 PubMed Authors: Raelene Endersby Telethon Kids Institute S.J. Baker Abstract. 12 juil. 2024 · PTEN exerts its tumor suppression function through the dephosphorylation of PIP3 and antagonizing PI3K-Akt signaling pathway with its lipid phosphatase activity. 3, 4 The previous study also. 1 juil. 2014 · We report that brain overgrowth is widespread in Pten germline haploinsufficient (Pten(+/-)) mice, reflecting Pten mRNA expression in the developing brain. We then ask if broad brain overgrowth translates into general or specific effects on the development of behavior and cognition by testing Pten(+/-) mice using assays relevant to. Between-subjects and mixed-model analyses of variance (ANOVAs) statistics for non-social tests of Pten tm1Rps mice. 4 févr. 2014 · We report that brain overgrowth is widespread in Pten germline haploinsufficient (Pten+/−) mice, reflecting Pten mRNA expression in the developing brain. Summary of behavioral test results in Pten tm1Rps and DAT-Cre +/−; Pten loxP/loxP mice. 5 déc. 2019 · Pten haploinsufficiency dysregulates coordinated growth across brain regions during development. This results in abnormally scaled brain areas and associated behavioral deficits, potentially. 15 juil. 2015 · Heterozygous mutations in PTEN (PTEN(+/-)), which encodes a negative regulator of the PI3K-Akt-mTOR pathway, are a risk factor for ASD and macrocephaly. Here we use the developing cerebral cortex of Pten(+/-) mice to investigate the trajectory of brain overgrowth and underlying cellular mechanisms. We find that overgrowth is. 7 juil. 2015 · Our present results inform these clinical genetic findings and indicate that Pten and β-catenin signaling act in a balance to regulate normal brain growth trajectory via control of cell number, and that disruption of this balance can lead to abnormal patterns of brain growth. 21 janv. 2024 · Chen Y, Huang WC, Séjourné J, Clipperton-Allen AE, Page DT. Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated β-Catenin Signaling. J Neurosci. 2015 Jul; 35 ((28)):10252–67. [PMC free article] [Google Scholar]. 15 juil. 2015 · We report that Pten haploinsufficiency leads to a dynamic trajectory of brain overgrowth during development and altered scaling of neuronal and glial cell populations. β-catenin signaling is. 15 juil. 2015 · It is reported that Pten haploinsufficiency leads to a dynamic trajectory of brain overgrowth during development and altered scaling of neuronal and glial cell populations, and disruption of this pathway can result in abnormal brain growth. Abnormal patterns of head and brain growth are a replicated finding in a subset of individuals. Model of the impact of Pten haploinsufficiency on the trajectory of corticogenesis. In this model, Pten haploinsufficiency leads to an exaggeration of the normal processes of neurogenesis, neuronal apoptosis, and gliogenesis that occur during cerebral cortical development. During embryonic neurogenesis, excess neurons are produced throughout.