Синтез jwh 018

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Синтез jwh 018

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WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. It gained popularity in late when German chemists found it as a chemical within the popular synthetic cannabis blend Spice, which had been sold in numerous countries around the world since Cannabinoids are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. JWH is orally active when dissolved in a lipid, which can increase the duration significantly. Like other cannabinoids , it is insoluble in water but dissolves in ethanol and lipids. Unlike cannabis , the chronic abuse of synthetic cannabinoids has been associated with multiple deaths and more dangerous side effects and toxicity in general. Therefore, it is very strongly discouraged to take this substance for extended periods of time or in excessive doses. JWH, or Naphthalenyl- 1-pentylindolyl methanone, is a synthetic cannabinoid containing a substituted indole structure. JWH is substituted at R 1 with a pentyl chain. Additionally, the indole core is substituted at R 3 with a carbonyl group which is also bonded to a napthalene moeity. Napthalene is a bicyclic structure of two fused benzene rings. This carbonyl bridge of JWH classifies it as a ketone. JWH is an analog of THJ , in which the core indazole structure is substituted with an indole base. Disclaimer: The effects listed below are cited from the Subjective Effect Index SEI , which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death. There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:. This toxicity and harm potential section is a stub. As such, it may contain incomplete or even dangerously wrong information. You can help by expanding or correcting it. We also recommend that you conduct independent research and use harm reduction practices when using this substance. The toxicity and long-term health effects of recreational JWH use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because the drug has very little history of human usage. Because of this, harm mediated by CB1 receptor agonism can be more severe than its partial agonist counterparts. It is strongly recommended that one use harm reduction practices when using this drug. As with other synthetic cannibanoids, the chronic use of JWH can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Tolerance to many of the effects of JWH develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline in the absence of further consumption. JWH presents cross-tolerance with all cannabinoids , meaning that after the consumption of JWH all cannabinoids will have a reduced effect. Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations although it cannot be guaranteed to include all of them. Independent research e. Google , DuckDuckGo should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit. Physical effects. Visual effects. Cognitive effects. Auditory effects. Cannabinoids as therapeutic agents. ISBN Synthetic cannabinoid use and psychosis: an explorative study. Journal of Drug and Alcohol Dependence Retrieved December 30, Bundesgesetzblatt Jahrgang Teil I Nr. Bundesanzeiger Verlag. January 21, Retrieved December 19, Navigation menu Personal tools Create account Log in. Namespaces Page Discussion. Views Read View source View history. Community Network YouTube Good vibes.