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Med Cannabis Cannabinoids 2 December ; 5 1 : 9— Methods: Twelve healthy male subjects received a single dose of AP 12 sprays containing 3. Results: The single dose of the applied oromucosal cannabinoid spray AP 12 sprays, 3. The oromucosal cannabinoid spray AP caused only minor psychotropic effects despite the relatively high dosage applied by healthy subjects. No serious adverse effects occurred. Overall, the oromucosal cannabinoid spray AP was well tolerated. Conclusion: Compared to currently available drugs on the market, higher AUC values could be detected for the oromucosal cannabinoid spray AP despite administration of a lower dose. These comparatively higher blood levels caused only minor psychotropic adverse effects. The oromucosal cannabinoid spray AP was well tolerated at a single dose of 3. The oromucosal administration may provide an easily applicable and titratable drug formulation with a high safety and tolerability profile. Sign In or Create an Account. Search Dropdown Menu. Advanced Search. Skip Nav Destination Close navigation menu Article navigation. Volume 5, Issue 1. Materials and Methods. Discussion and Conclusions. Statement of Ethics. Conflict of Interest Statement. Funding Sources. Author Contributions. Data Availability Statement. Article Navigation. Research Articles January 18 Stefan Lorenzl ; Stefan Lorenzl. This Site. Google Scholar. Franz Gottwald ; Franz Gottwald. Angelika Nistler ; Angelika Nistler. Laura Brehm ; Laura Brehm. Heimer, Holzkirchen, Germany. Georg Haber ; Georg Haber. Christian Bremm ; Christian Bremm. Christiane Weck ; Christiane Weck. Carina Trummer ; Carina Trummer. Werner Brand Werner Brand. Med Cannabis Cannabinoids 5 1 : 9— Article history Received:. Cite Icon Cite. View full article. View Metrics. Email alerts Online First Alert. Continuous Publishing Alert. New Content Alert. Citing articles via Google Scholar. CrossRef 2. Cannabinoids for the Treatment of Glaucoma: A Review. Online ISSN Karger International S. Karger AG P. Karger AG, Basel. Close Modal.

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