Saliva Deepthroat
⚡ ALL INFORMATION CLICK HERE 👈🏻👈🏻👈🏻
Saliva Deepthroat
Clipboard, Search History, and several other advanced features are temporarily unavailable.
Dashboard
Publications
Account settings
Log out
Advanced
Clipboard
Format
Abstract
PubMed
PMID
Format:
Summary (text)
PubMed
PMID
Abstract (text)
CSV
Subject:
1 selected item: 33774101 - PubMed
Format:
Summary
Summary (text)
Abstract
Abstract (text)
Create a new collection
Add to an existing collection
Name must be less than 100 characters
Unable to load your collection due to an error
Please try again
Unable to load your delegates due to an error
Please try again
Would you like email updates of new search results?
Saved Search Alert Radio Buttons
Yes
No
Frequency:
Monthly
Weekly
Daily
Which day?
The first Sunday
The first Monday
The first Tuesday
The first Wednesday
The first Thursday
The first Friday
The first Saturday
The first day
The first weekday
Which day?
Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Report format:
Summary
Summary (text)
Abstract
Abstract (text)
PubMed
Send at most:
1 item
5 items
10 items
20 items
50 items
100 items
200 items
Send even when there aren't any new results
Number of items displayed:
5
10
15
20
50
100
Page navigation
Title & authors
Abstract
Figures
Similar articles
Cited by
References
Publication types
MeSH terms
Related information
LinkOut - more resources
Affiliations
1 Department of Oral and Maxillofacial surgery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: Khiabani_ak@yahoo.com.
2 Department of Research, Arka Education and Clinical Research Consultants, Tehran, Iran; Universal Network of Interdisciplinary Research in Oral and Maxillofacial Surgery (UNIROMS), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Kazem Khiabani et al.
Am J Infect Control .
2021 Sep .
Format
Abstract
PubMed
PMID
Affiliations
1 Department of Oral and Maxillofacial surgery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: Khiabani_ak@yahoo.com.
2 Department of Research, Arka Education and Clinical Research Consultants, Tehran, Iran; Universal Network of Interdisciplinary Research in Oral and Maxillofacial Surgery (UNIROMS), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
The forest plot of SARS-CoV-2 detection sensitivity of saliva, based on RT-PCR analysis from symptomatic COVID-19 patients regarding the disease's severity.
The forest plot of SARS-CoV-2 detection sensitivity of deep throat sputum based on RT-PCR analysis from symptomatic COVID-19 patients regarding the disease's severity.
The forest plot of SARS-CoV-2 detection sensitivity of the nasopharyngeal sample and double naso/oropharyngeal samples based on RT-PCR analysis from symptomatic COVID-19 patients regarding the disease's severity.
(A) Summary of the quality assessment of the included saliva-based studies; (B) Summary of the quality assessment of the included DTS-based studies.
Wong RC, Wong AH, Ho YI, Leung EC, Lai RW.
Wong RC, et al.
J Clin Virol. 2020 Oct;131:104593. doi: 10.1016/j.jcv.2020.104593. Epub 2020 Aug 16.
J Clin Virol. 2020.
PMID: 32823131
Free PMC article.
Moreira VM, Mascarenhas P, Machado V, Botelho J, Mendes JJ, Taveira N, Almeida MG.
Moreira VM, et al.
Diagnostics (Basel). 2021 Feb 21;11(2):363. doi: 10.3390/diagnostics11020363.
Diagnostics (Basel). 2021.
PMID: 33670020
Free PMC article.
Review.
Tsang NNY, So HC, Ng KY, Cowling BJ, Leung GM, Ip DKM.
Tsang NNY, et al.
Lancet Infect Dis. 2021 Sep;21(9):1233-1245. doi: 10.1016/S1473-3099(21)00146-8. Epub 2021 Apr 12.
Lancet Infect Dis. 2021.
PMID: 33857405
Free PMC article.
Lai CKC, Chen Z, Lui G, Ling L, Li T, Wong MCS, Ng RWY, Tso EYK, Ho T, Fung KSC, Ng ST, Wong BKC, Boon SS, Hui DSC, Chan PKS.
Lai CKC, et al.
J Infect Dis. 2020 Oct 13;222(10):1612-1619. doi: 10.1093/infdis/jiaa487.
J Infect Dis. 2020.
PMID: 32738137
Free PMC article.
Lee RA, Herigon JC, Benedetti A, Pollock NR, Denkinger CM.
Lee RA, et al.
J Clin Microbiol. 2021 Apr 20;59(5):e02881-20. doi: 10.1128/JCM.02881-20. Print 2021 Apr 20.
J Clin Microbiol. 2021.
PMID: 33504593
Free PMC article.
Review.
Huang SC, Pak TK, Graber CP, Searby CC, Liu G, Marcy J, Yaszemski AK, Bedell K, Bui E, Perlman S, Zhang Q, Wang K, Sheffield VC, Carter CS.
Huang SC, et al.
PeerJ. 2022 May 10;10:e13277. doi: 10.7717/peerj.13277. eCollection 2022.
PeerJ. 2022.
PMID: 35573180
Free PMC article.
Nwanochie E, Linnes JC.
Nwanochie E, et al.
J Breath Res. 2022 Mar 18;16(2):10.1088/1752-7163/ac59c7. doi: 10.1088/1752-7163/ac59c7.
J Breath Res. 2022.
PMID: 35235925
Review.
Ahmadieh A, Dincer S, Navazesh M.
Ahmadieh A, et al.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2022 May;133(5):530-538. doi: 10.1016/j.oooo.2022.01.002. Epub 2022 Jan 10.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2022.
PMID: 35227640
Free PMC article.
Review.
Nascimento MHC, Marcarini WD, Folli GS, da Silva Filho WG, Barbosa LL, Paulo EH, Vassallo PF, Mill JG, Barauna VG, Martin FL, de Castro EVR, Romão W, Filgueiras PR.
Nascimento MHC, et al.
Anal Chem. 2022 Feb 8;94(5):2425-2433. doi: 10.1021/acs.analchem.1c04162. Epub 2022 Jan 25.
Anal Chem. 2022.
PMID: 35076208
Free PMC article.
Wang H, Shao G, Zhang K.
Wang H, et al.
Am J Transl Res. 2021 Nov 15;13(11):12897-12904. eCollection 2021.
Am J Transl Res. 2021.
PMID: 34956505
Free PMC article.
Related information
MedGen
Format:
AMA
APA
MLA
NLM
Send To
Clipboard
Email
Save
My Bibliography
Collections
Citation Manager
[x]
NLM
NIH
HHS
USA.gov
An official website of the United States government
The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before
sharing sensitive information, make sure you’re on a federal
government site.
The site is secure.
The https:// ensures that you are connecting to the
official website and that any information you provide is encrypted
and transmitted securely.
Objective:
The COVID-19 pandemic raises an urgent need for large-scale control through easier, cheaper, and safer diagnostic specimens, including saliva and sputum. We aimed to conduct a systemic review and meta-analysis on the reliability and sensitivity of SARS-CoV-2 detection in saliva and deep throat sputum (DTS) compared to nasopharyngeal, combined naso/oropharyngeal, and oropharyngeal swabs.
Methods:
This systematic review and meta-analysis was performed according to the PRISMA statement. The inclusion criteria were studies that specifically assessed a sample of saliva or DTS with at least one other respiratory specimen in patients with COVID-19 infection, based on RT-PCR tests. The DerSimonian-Laird bivariate random-effects model analysis performed using STATA software with the "metaprop" package.
Results:
From 1598 studies, we retrieved 33 records, of which 26 studies were included for quantitative analysis. We found an overall sensitivity of 97% (95% confidence interval [CI], 86-100) for bronchoalveolar lavage fluid, 92% (95% CI, 80-99) for double naso/oropharyngeal swabs, 87% (95% CI, 77-95) for nasopharyngeal swabs, 83% (95% CI, 77-89) for saliva, 82% (95% CI, 76-88) for DTS, and 44% (95% CI, 35-52) for oropharyngeal swabs among symptomatic patients, respectively. Regardless of the type of specimens, the viral load and sensitivity in the severe patients were higher than mild and in the symptomatic patients higher than asymptomatic cases.
Conclusions:
The present review provides evidence for the diagnostic value of different respiratory specimens and supports saliva and DTS as promising diagnostic tools for first-line screening of SARS-CoV-2 infection. However, the methods of sampling, storing, and laboratory assay need to be optimized and validated before introducing as a definitive diagnosis tool. Saliva, DTS, and nasopharyngeal swab showed approximately similar results, and sensitivity was directly related to the disease severity. This review revealed a relationship between viral load, disease severity, and test sensitivity. None of the specimens showed appropriate diagnostic sensitivity for asymptomatic patients.
Keywords:
COVID-19; Nasopharyngeal swab; Oropharyngeal swab; RT-PCR diagnostic test; Sensitivity; Sputum.
Copyright © 2021 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
The forest plot of SARS-CoV-2 detection sensitivity of saliva, based on RT-PCR analysis…
The forest plot of SARS-CoV-2 detection sensitivity of deep throat sputum based on…
The forest plot of SARS-CoV-2 detection sensitivity of the nasopharyngeal sample and double…
(A) Summary of the quality assessment of the included saliva-based studies; (B) Summary…
MeSH
PMC
Bookshelf
Disclaimer
Help
Accessibility
Careers
Clipboard, Search History, and several other advanced features are temporarily unavailable.
Dashboard
Publications
Account settings
Log out
Advanced
Clipboard
Format
Abstract
PubMed
PMID
Format:
Summary (text)
PubMed
PMID
Abstract (text)
CSV
Subject:
1 selected item: 33774101 - PubMed
Format:
Summary
Summary (text)
Abstract
Abstract (text)
Create a new collection
Add to an existing collection
Name must be less than 100 characters
Unable to load your collection due to an error
Please try again
Unable to load your delegates due to an error
Please try again
Would you like email updates of new search results?
Saved Search Alert Radio Buttons
Yes
No
Frequency:
Monthly
Weekly
Daily
Which day?
The first Sunday
The first Monday
The first Tuesday
The first Wednesday
The first Thursday
The first Friday
The first Saturday
The first day
The first weekday
Which day?
Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Report format:
Summary
Summary (text)
Abstract
Abstract (text)
PubMed
Send at most:
1 item
5 items
10 items
20 items
50 items
100 items
200 items
Send even when there aren't any new results
Number of items displayed:
5
10
15
20
50
100
Page navigation
Title & authors
Abstract
Figures
Similar articles
Cited by
References
Publication types
MeSH terms
Related information
LinkOut - more resources
Affiliations
1 Department of Oral and Maxillofacial surgery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: Khiabani_ak@yahoo.com.
2 Department of Research, Arka Education and Clinical Research Consultants, Tehran, Iran; Universal Network of Interdisciplinary Research in Oral and Maxillofacial Surgery (UNIROMS), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Kazem Khiabani et al.
Am J Infect Control .
2021 Sep .
Format
Abstract
PubMed
PMID
Affiliations
1 Department of Oral and Maxillofacial surgery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: Khiabani_ak@yahoo.com.
2 Department of Research, Arka Education and Clinical Research Consultants, Tehran, Iran; Universal Network of Interdisciplinary Research in Oral and Maxillofacial Surgery (UNIROMS), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
The forest plot of SARS-CoV-2 detection sensitivity of saliva, based on RT-PCR analysis from symptomatic COVID-19 patients regarding the disease's severity.
The forest plot of SARS-CoV-2 detection sensitivity of deep throat sputum based on RT-PCR analysis from symptomatic COVID-19 patients regarding the disease's severity.
The forest plot of SARS-CoV-2 detection sensitivity of the nasopharyngeal sample an
Naked Rebel Girls
Valerie Leon Tits
Squatting Pussy