S 4 Female

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S 4 Female

Written by Biljana Novkovic, PhD
| Last updated:

November 3, 2021




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Biljana received her PhD from Hokkaido University.
Before joining SelfHacked, she was a research scientist with extensive field and laboratory experience. She spent 4 years reviewing the scientific literature on supplements, lab tests and other areas of health sciences. She is passionate about releasing the most accurate science and health information available on topics, and she's meticulous when writing and reviewing articles to make sure the science is sound. She believes that SelfHacked has the best science that is also layperson-friendly on the web.
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Andarine is a SARM developed to treat muscle wasting and osteoporosis. It has shown promise in animal studies, where it increased bone density and muscle mass. However, it was abandoned in early human clinical trials due to serious safety concerns. People who still use it illegally tend to be unaware of the dangers, which are downplayed in bodybuilding blogs. Read on to learn more about this drug and its side effects.
Disclaimer : We highly recommend against using this drug since its effects and safety are unknown. Therefore, we are presenting the available information from the clinical and scientific literature with the aim of helping readers understand the dangers involved.
Andarine, also known as S-4, S-40503, or 8, is a SARM developed with the aim of treating osteoporosis and muscle wasting.
SARMs (selective androgen receptor modulators) are drugs that bind to the androgen receptor (AR) , which is the main site of action of the hormone testosterone.
In the early days, Andarine was described as the ideal SARM due to high oral bioavailability and great muscle- and bone-building effects (studied in animals) [ 1 ].
Phase I human trials with this drug have reportedly been successful but no studies have been published. However, further development of the drug was abandoned in favor of Ostarine , another SARM with a similar structure, also known as S-22 [ 2 ].
This was likely because of Andarine’s poor safety profile. It caused vision-related side effects, which further adds to the long list of reasons against ever taking this drug.
Andarine has a high affinity for the androgen receptor ( AR ) and therefore mimics the effects of testosterone. However, its effects are much stronger in muscles and bones than in reproductive organs. That is why Andarine and other SARMs are hypothesized to cause fewer side effects than anabolic steroids [ 3 ].
Bodybuilders tend to take this unapproved theory as “proof” that they won’t have to deal with severe testosterone suppression and increased estrogens if they take SARMs. However, this is far from true.
In reality, the “SARMs selectivity theory” might be completely false. It has never been proven, and SARMs like Andarine and Ostarine never passed proper clinical trials. SARMs may turn out to be much more dangerous than previously thought.
This section focuses on the clinical and scientific research that has been done on Andarine so far.
Anadarine has never been properly studied in humans. 
Based on the existing data, its effects are unknown and its potential to cause harm is high.
This drug was developed to prevent muscle wasting, and animal studies do indeed show that Andarine improves muscle growth and strength in animals.
When given to castrated rats for 4 weeks, Andarine increased muscle weight as markedly as DHT (dihydrotestosterone). Moreover, unlike DHT, Andarine caused no prostate enlargement, which is a concern when taking steroids [ 4 ].
Twelve weeks after castration, Andarine was able to restore lean body (muscle) mass in rats [ 5 ].
Andarine increased bone mineral density and strength in both in castrated male rats and in female rats whose ovaries had been removed (this is a commonly used animal model of osteoporosis) [ 4 , 5 , 6 , 7 ].
Andarine may be especially beneficial in osteoporosis because, in addition to improving bone density, it also improves muscle strength, which may help reduce the risk of falls and fractures [ 7 ].
In female rats whose ovaries have been removed, apart from improving bone strength, Andarine also decreased body fat [ 7 ].
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Andarine is an unapproved drug with completely unknown effects on the body.
SARMs are hypothesized to have fewer side effects than anabolic steroids. This remains unproven.
People misperceive SARMS like Andarine as safer due to a basic misunderstanding of the available scientific data, which is hyped in various bodybuilding blogs.
However, the “SARMS selectivity theory,” based on which people talk about reduced side effects, has never been proven. SARMs like Andarine never passed proper clinical trials. SARMs may even turn out to be more dangerous than many other substances (steroids and testosterone included).
LH (luteinizing hormone) and FSH (follicle stimulating hormone) promote the production of reproductive hormones in men and women, and their suppression could suppress normal estrogen / testosterone levels. Andarine suppressed LH and FSH in castrated rats where these hormones were elevated as a result of castration. However, it had no effect in normal male rats [ 8 , 3 ].
All in all, it is unknown if and how much Andarine would suppress testosterone/estrogen production in humans.
The most frequent user-reported side effects are visual issues such as a yellow tint and difficulty adjusting to night vision. These disappear after the drug has been discontinued. Higher doses seem to cause stronger side effects. Some users also report depression.
The safety and effects of Andarine have not been explored in humans or the studies aren’t publically available. This drug was mainly tested in rats.
Although it is purchased online, its long-term benefits and risks in humans are unknown.
Since 2008, the use of SARMs has been considered doping by the US Anti-Doping Agency (USADA), and these drugs are on the World Anti-Doping Agency (WADA) prohibited list [ 9 ].
The use of Andarine in competitive and professional sports is, thus, illegal.
This drug is not approved by the FDA for any purpose.
There is no safe dose for this drug since it has not passed proper clinical trials or received approval from any regulatory body. 
In rats and dogs, Andarine is bioavailable, with an average half-life of approximately 200 minutes [ 10 , 11 ].
Here we summarized the available dosage data from online communities with the attempt to additionally warn people about the dangers of taking this unapproved drug.
According to users, a common dosing range is 50 to 75 mg per day (divided into 3 doses taken with meals). Some start with lower doses of 25 to 50 mg per day. Andarine is often cycled.
This drug is unapproved, so the quality and even the identity of the product is often highly questionable . In a study of 44 products marketed as SARMs (including Andarine), only 52% actually contained SARMs and many were inaccurately labeled [ 12 ].
We at SelfDecode advise speaking to a doctor before taking any drug, especially an unscheduled drug with limited long-term safety data in humans
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SARMS Dylan Gemelli Fact Checked by Dr. Chekanov Nikolai 1 Comment 444 views 10 likes 9 years ago
Dylan Gemelli is a Certified personal trainer and Coach. He has over 15 years of experience in bodybuilding, fitness, training and coaching. He's worked with multiple movie stars, IFBB pros and fitness celebs on their training and diet. He's helped set up cycles for the greatest in our industry. He holds the following qualifications:
NASM Personal Trainer
NASM Corrective Exercise Specialist
AFAA Group Fitness
NASM Fitness Nutrition Specialist
NASM Weight Loss Specialist
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As a research chemical, S-4 belongs to a class of chemicals known as SARMS or selective androgen receptor modulators. Like typical androgens, SARMS bind to the androgen receptor however SARMS create selective anabolic activity.
Compared to testosterone and other anabolic steroids and pro hormones, the advantage of SARMS such as S-4 is that they do not have androgenic activity in non-skeletal-muscle tissues.
S4 was designed for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy, using the non-steroidal androgen antagonist bicalutamide as a lead compound.
As an orally active partial agonist for androgen receptors, S-4 is effective in not only maintaining lean body mass but actually increasing it.
Selective androgen receptor modulators (SARMS) bind to the androgen receptor and demonstrate osteo (bone) and myo (muscular) anabolic activity.
Binding and activation of the Androgen receptor alters the expression of genes and increases protein synthesis which ultimately builds muscle.
SARMS such as S4 can cause muscle growth in the same manner as steroids, however unlike testosterone and other anabolic steroids, SARMS (as nonsteroidal agents) do not produce the growth effect on prostate and other secondary sexual organs.
SARMS not only represent a new potential treatment option for a wide spectrum of conditions such as muscle wasting diseases (from age-related to AIDS or cancer-related), but they also have immense potential for muscle building for Bodybuilders, fitness and athletes.
S-4 in particular binds to the androgen receptor in muscle and bone to a third of the affinity of Testosterone.
S-4 (3 mg/kg/day) was also able to restore skeletal muscle (i.e., soleus muscle) and strength in castrated rats, important and applicable for the treatment of muscle wasting and male HRT.
A 120-day study comparing SARM S-4 and dihydrotestosterone (DHT) treatment in ovariectomized rats demonstrated that S-4 was able to maintain bone mass and bone strength to the levels of intact controls and exhibited greater efficacy than DHT.
S-4 also demonstrated the ability to improve skeletal (soleus) muscle strength, increase lean body mass, reduce body fat, and prevent bone loss.
Cutting is the environment where S-4 truly shines.
Certain steroids are considered “cutting” steroids such as Winstrol and Anavar. These steroids don’t offer too much in large gains in muscle mass but are very effective in leaning out the body. The SARM S-4 has very similar properties.
The presence of androgen receptors in human preadipocytes and adipocytes suggests that androgens may contribute, through regulation of their own receptors, to the control of adipose tissue development. As S-4 shows this binding affinity to the AR, it demonstrates the similar fat burning effects. S-4 also shows a decrease in LPL (lipoprotein lipase) which is an enzyme that causes lipid accumulation.
S-4 also fits into a cutting protocol for the concurrent reduction in body fat with maintenance of muscle mass in a hypocaloric environment.
One of the most disheartening outcomes of cutting is the loss hard earned muscle mass. The drop in metabolic rate and hormone levels (T3, IGF, Testosterone etc) with the lack of calories is a perfect catabolic environment for loss of muscle tissue.
As S4 has both anabolic and androgenic effects in muscle tissue, it will not only help with fat loss, but maintain and even increase muscle mass when cutting.
S-4 causes increases in vascularity and promote a very nice, “quality”, hard look to the users muscles, with little or no water retention.
In this way S-4 can be compared to Winstrol , without the harsh hair loss or extreme adverse effects on cholesterol.
Also other popular steroids/Prohormones used for cutting such as winstrol or epistane can have a notable effect on drying out of the joints. S-4 doesn’t suffer such consequences so the athlete is still able to lift heavy in order to maintain/increase muscle mass and strength.
Another advantage S-4 offers for cutting is that it doesn’t give the painful pumps associated with other popular steroids/Prohormones. Back and calf pumps are particularly detrimental for cutting as it limits the ability to perform cardio.
A 50mg dosing protocol for 6-8 weeks is ideal for cutting purposes for the majority of users.
However due to the vision side effects, if running at these doses some like to follow a 5 on 2 off protocol where S4 is used for 5 days followed by a 2 day break (then this cycle is repeated).
The recomping effect of losing fat and gaining muscle at the same time is what the majority of users are looking for. Trying to achieve this when you are not absolutely new to training is extremely difficult.
One of the most important factors of recomping is time. As you are trying to achieve multiple objectives, it requires a longer time period to notice good recomp effects so even when running steroids, these would have to be longer run injectable compounds as oppose to the short run liver toxic oral steroids.
Although S-4 is taken orally, it is not methylated and is not liver toxic like other AAS/PH/DS’s. As it prevents this side effect and many others, it can be ran for 6+weeks, sufficient time to get a good body recomp.
A dosing protocol of 50-75mg for 4-8 weeks will give good recomp effects
Diet must also be optimized to where calories are just above maintenance with at least 30% coming from lean sources of protein to get the best recomp effect.
Of course, the recomp effects could be even greater if stacked or combined with a more anabolic SARM such as Ostarine .
Due to its androgenicity in muscle tissue, S-4 is a good agent for increases in strength without bloat and large increases in weight.
Dosing at 50mg+ is the sweet spot for such gains.
Also due to its anabolic nature, these strength gains will come with associated gains in lean mass, albeit smaller than other more anabolic SARMS such as Ostarine.
Also, like the oral steroid Anavar (Var) weight gain with S4 may not be that great in comparison to bulking steroids such as deca or Superdrol, but what the lean mass and strength gained during the cycle is kept and not lost after the cycle.
With all dosing protocols, as the half life of S-4 is 4 hours, splitting up the dose into multiple applications is advised.
Also due to this short half life, users have found that taking one of these doses pre WO will offer increased performance in the gym.
SARMS cannot be aromatized, conferring all their effects to AR binding and not to metabolic conversion to active androgens/estrogens.
Unlike Ostarine where blood work from users has shown a slight elevation in serum estradiol levels, S-4 does not show any such elevation. As it has slight androgenic activity, it in fact gives the opposite effects and reduces bloat and other estrogenic effects. This is evident with the aforementioned hardening effects that S4 gives.
Advantages Of S4 when compared to Steroids/Prohormones
It is non methylated so it is not toxic to the liver or blood pressure
Some suppression may be present at doses of 50mg+ run for longer than 4 weeks, however a full PCT of prescription SERMs like nolva or clomid is not necessary.
Great sense of well being while on, (without the aggression which can often detrimentally impact users daily lives).
No need for a long time period off between cycles; the recommended time of period for normal steroid cycles would be Time on + PCT, so for a typical 6 week cycle and 4 week PCT, a user would have to wait another 10 weeks after PCT to start another cycle where SARMS recovery requires minimal rest in between.
Although S-4 negates the side effects listed above, there is one very unique side effect that comes with its use.
When run at the 50mg+ doses, many users report vision disturbances. Now these are only present when using S-4 and quickly disappear when S-4 use is discontinued.
The side effects are caused by the M1 metabolite and include night-time blindness and a slight yellowish tint to the vision for some users.
Although these side effects are temporary, if they are still a concern, as suggested earlier, a 5 on 2 off protocol where S-4 is used for 5 days followed by a 2 day break (then this cycle is repeated) would be the suggested dosing method.
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