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Neuropsychiatrische Funktion und Pathologie des NMDA-Rezeptors

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The mammalian olfactory system possesses immense discriminatory power. It can generate diverse odor perceptions to a vast array of volatile odorants and stimulate instinctive behaviors and hormonal changes to conspecific and inter-specific social cues. Our work has focused on two questions. First, how do mammals detect so many different chemicals. And second, how does the nervous system translate those chemicals into diverse perceptions and innate responses. Using a combination of molecular, cellular, and genetic approaches, we have identified four different families of chemosensory receptors expressed by sensory neurons in the olfactory epithelium and vomeronasal organ and interrogated how signals from different receptors are organized and used to encode chemical identities in these peripheral sense organs and in the main olfactory bulb. Our recent studies indicate that neurons expressing odorant receptors ORs and TAARs belong to different lineages of nasal sensory neurons and that distinct nuclear locations of these receptors may underlie their segregated expression. We are currently using viral tracers and pharmacogenetic methods to gain insight into the neural circuits underlying instinctive responses to social cues. Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:. Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account. Choose this option to get remote access when outside your institution. Enter your library card number to sign in. If you cannot sign in, please contact your librarian. 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