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Disclosures:
The authors report no relevant financial disclosures. The study was funded by a postdoctoral scholarship from the University of Bergen awarded to Triebner.
Disclosures:
The authors report no relevant financial disclosures. The study was funded by a postdoctoral scholarship from the University of Bergen awarded to Triebner.
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By Matthew Stenger et al.,
Breast Cancer, 2013
By Matthew Stenger et al.,
Breast Cancer, 2013
By Matthew Stenger,
The ASCO Post, 2013
By Matthew Stenger,
The ASCO Post, 2013
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Low levels of serum estrogen and progesterone in middle-aged women were linked to a higher risk for obstructive sleep apnea symptoms, according to a population-based study published in PLOS ONE .
“Considering that [obstructive sleep apnea (OSA)] may lead to cardiovascular conditions (ischemic heart disease and stroke), which are among the greatest contributors to mortality worldwide, gaining a broader understanding of the reasons for the increased propensity of postmenopausal women to develop OSA is important,” Kai Triebner , PhD , a postdoctoral researcher at the University of Bergen in Norway at the time of the study, and colleagues wrote.
Triebner and colleagues studied 774 women (age range, 40 to 67 years) who completed the second follow-up of the European Community Respiratory Health Survey from 2010 to 2012 to determine if female sex hormones were associated with the prevalence of sleep apnea symptoms in women their age . Participants came from 15 study centers across seven countries.
The researchers used a respiratory health and lifestyle factors questionnaire, a sleep questionnaire, blood samples for hormone analyses and anthropometric measurements to examine participants. Participants self-reported snoring if they had ever been told they snored. If participants reported snoring, the researchers asked follow-up questions on irregular breathing, gasping and disturbing snore.
Triebner and colleagues created logistic regression models to assess the effect of serum estrogens and progesterone on snoring and sleep apnea-related outcomes.
Overall, when serum concentrations of estrogen and progesterone were doubled, the odds of snoring were decreased by 19% and 9%, respectively.
Within the cohort, 551 women reported snoring, and 411 of those answered affirmatively to at least one of the follow-up OSA questions.
Among women who snored, doubling of estrogens and progesterone were also associated with decreased odds of OSA symptoms. Specifically, a doubling of 17B-estradiol, estrone and estrone 3-sulfate were linked to 18%, 23% and 17% decreased odds of irregular breathing, and a doubling of progesterone was linked to 12% decreased odds of waking up suddenly with a choking sensation or gasping. No statistically significant associations were found for disturbing snore.
Sensitivity analyses confirmed these associations, and mutually adjusted models showed findings similar to the main analyses.
Triebner and colleagues wrote that more longitudinal studies are “highly warranted.”
“It is crucial to develop strategies to decrease the high prevalence and associated morbidity of OSA and adjusting female sex hormones levels might be the key to accomplish this, but further longitudinal studies with repeated measures of sex hormones and objective characterization of OSA are required to confirm our findings in other settings,” Triebner and colleagues wrote.
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PITTSBURGH — A child’s history of depression and concussion within the previous year, along with their race, ethnicity and sex, can help predict the likelihood of a suicide attempt, according to a new study led by University of Pittsburgh School of Medicine researchers.
The study, published today in JAMA Network Open,is one of the first to delve into the complex relationship between race, ethnicity, depression and concussion in teenagers and pre-teens. The researchers gathered data from over 28,000 children in 9th through 12th grades who completed a national survey on their history of depression and whether they had a concussion caused by physical activity, which revealed eye-opening statistics about what groups were at risk for suicide attempts.
Among children who were depressed, concussion increased the risk for reporting a suicide attempt by 31%.If the child reported depression and concussion in the previous year, being Black, Hispanic or Latino, or multiracial enhanced risk for a suicide attempt by an additional 28%. Within that group, females had a 33% increased risk of a suicide attempt compared to males.
“Depression is a major predictor of a suicide attempt, which is why we wanted to look at children with and without depression. But our primary goal was to investigate if concussion would magnify risk for certain subgroups based on race, ethnicity and biological sex,” said Dr. Shawn Eagle, lead author and research assistant professor in Pitt’s Department of Neurological Surgery.
They also found that for children without a history of depression, race and ethnicity played a greater role in predicting a suicide attempt than concussion incidence. Data showed that American Indian, Alaska Native, Black, Native Hawaiian and Pacific Islander youth had an 89% increased risk of a suicide attempt compared to the rest of the survey respondents who did not report depression. In this group, concussion history did not increase the likelihood of a suicide attempt compared to race and ethnicity. However, concussion history did increase the risk for a suicide attempt within the remaining racial and ethnic groups by 29%.
Eagle points out that increased risk for suicide attempts with no reported depression history in certain racial and ethnic groups compared to others suggests how critical race and ethnicity can be to a child’s mental well-being in the United States.
This study included more than 28,000 survey participants, with 3,874 children reporting that they had suffered concussions in the last year. Overall, approximately 1,900 children said they had attempted suicide. Of those who had a suicide attempt, 80% reported experiencing depression within the year.
Data was collected from The Youth Risk Behavior Surveillance System (YRBSS), a Centers for Disease Control and Prevention-sponsored survey that monitors six categories of health-related behaviors that contribute to the leading causes of death and disability among youth and adults.
“Providers who work with children should conduct regular depression screenings and be mindful of certain subgroups that have increased risk for suicide attempts,” said Eagle. “And providers who work with children who may have had a recent concussion should conduct depression screenings more often.”
Prior studies have examined the association of concussions and suicide attempts in select minority groups as compared to white people, but this study is the first to compare ethnic and racial groups in a more detailed way, said co-author Anthony Kontos, Ph.D., director of research for the UPMC Sports Medicine Concussion Program and professor in the Department of Orthopaedic Surgery in Pitt’s School of Medicine.
“By looking more specifically at individual racial and ethnic groups, our findings provide more targeted data about each group’s risk factors, thereby improving our potential to develop more effective strategies to enhance patient care for these underserved groups,” he said.
The research team notes that the YRBSS data does not capture key variables and they cannot verify the information reported in the surveys. The surveys do not include details of when a child suffered a concussion or experienced depression, which could yield critical information about how these variables may directly lead to suicide attempts.
Eagle hopes future research will follow a large number of children over time to better understand how and why some groups are more vulnerable than others and determine the timeline of concussion, depression and suicide attempts.
Additional authors on the study include David Brent, M.D., Raymond Pan, M.D., Martina Anto-Ocrah, Ph.D., David O. Okonkwo, M.D., Ph.D., and Michael W. Collins, Ph.D., all of Pitt; Tracey Covassin, Ph.D., of Michigan State University; Robert J. Elbin, Ph.D., of University of Arkansas; Jessica Wallace, Ph.D., of University of Alabama; and Justus Ortega, Ph.D., of Humboldt State University.
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Low levels of serum estrogen and progesterone in middle-aged women were linked to a higher risk for obstructive sleep apnea symptoms, according to a population-based study published in PLOS ONE.
PITTSBURGH — A child's history of depression and concussion within the previous year, along with their race, ethnicity and sex, can help predict the likelihood of a suicide attempt, according to a new study led by University of Pittsburgh School of Medicine researchers. The study, published today in JAMA Network Open,is one of the first […]
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Not many results contain fucking Search only for risky "fucking" ?
Risky Sex nsfw I (29m) have a breeding kink (of course I do), but I've been thinking about the idea of risky , bare sex with the possibility of impregnation. I'm curious if there are women here who are interested in or have thought of having risky , bare sex where there is deep finishing inside. No condoms, no pulling out.
Sex is a normal, healthy part of life. It should be fun and pleasurable for you and your partner. But it can also be risky if you or your partner do certain things that could spread disease or ...
Low levels of serum estrogen and progesterone in middle-aged women were linked to a higher risk for obstructive sleep apnea symptoms, according to a population-based study published in PLOS ONE.
PITTSBURGH — A child's history of depression and concussion within the previous year, along with their race, ethnicity and sex, can help predict the likelihood of a suicide attempt, according to a new study led by University of Pittsburgh School of Medicine researchers. The study, published today in JAMA Network Open,is one of the first […]
Help your friends and family join the Duck Side!
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Switch to DuckDuckGo and take back your privacy!
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