Rina Kato
⚡ ПОДРОБНЕЕ ЖМИТЕ ЗДЕСЬ 👈🏻👈🏻👈🏻
Rina Kato
Account Notifications Security Log Out
Women's Qualifying Series
2019
2018
2016
Follow your favorites and never miss a wave.
Follow your favorites and never miss a wave.
Do Not Sell My Personal Information
Download it for free on the App store.
Download it for free on Google Play.
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile. It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community. If you're a ResearchGate member, you can follow this page to keep up with this author's work. If you are this author, and you don't want us to display this page anymore, please let us know .
We found previously that fibronectin (FN) has a cryptic functional site (YTIYVIAL sequence within the 14th type III repeat) opposing cell adhesion to extracellular matrix. A 22-mer FN peptide containing this site, termed FNIII14, inhibits beta1 integrin-mediated adhesion without binding to integrins. The present study shows that FNIII14 has the pot...
Here, we show that fibronectin (FN) peptides derived from two distinct regions promote the insulin-induced adipocyte differentiation of ST-13 cells by preventing FN fibrillogenesis. ST-13 cells formed numerous FN fibrils under nonadipogenic conditions, whereas this FN fibrillogenesis was suppressed by adipose induction with insulin. The insulin-ind...
We previously found that fibronectin (FN) had a functional site (YTIYVIAL sequence in the 14th type III module) suppressing the integrin-mediated cell adhesion to extracellular matrix. FN-derived peptides containing this antiadhesive site were also shown to regulate cellular processes such as proliferation, differentiation, and apoptosis. The prese...
We previously showed that in passive Heymann nephritis (PHN) rats, a large quantity of fibronectin (FN) fragments containing the central cell-binding (CCB) domain and adjacent domains are generated in the kidney and excreted into urine (Nishizawa et al., Biol Pharm Bull 1998; 21: 429-433). To ascertain whether the FN fragments could affect the prog...
Hepatic Ito (stellate) cells represent the quiescent phenotype (i.e. many lipid droplets, low proliferative activity) in healthy liver. During chronic inflammation of the liver, Ito cells acquire the activated phenotype characterized by loss of lipid droplets, high proliferative ability, expressed a-smooth muscle (SM) actin, and highly increased pr...
... Hepatic stellate cells are usually quiescent, with low proliferative potential, and act as vitamin A storage cells, but are converted to myofibroblasts by inflammatory stimulation and become proliferative and capable of forming fibers. The inactivation of β1-integrin by peptide FNIII14 was shown to inhibit the myofibroblastic conversion of rat hepatic stellate cells (HSC) [18] . Freshly isolated rat HSC differentiate into myofibroblasts during culture with fetal bovine serum, as determined by various phenotypic activation characteristics of rat HSC such as increased proliferation, loss of vitamin A-rich lipid droplets, and expression of α-smooth muscle actin, but these characteristics are impeded by peptide FNIII14 [18]. ...
... These results suggest that anti-adhesive activity is closely associated with the sequence YTIVIAL, typically buried within the structure of 14th FN type III structure due to its hydrophobic nature [12]. 125 I-labeled FN fragment containing the RGD cell adhesion site binds to the cell surface via β1-integrin and was dissociated by peptide FNIII14, with concomitant binding of peptide FNIII14 to the cell surface, suggesting that peptide FNIII14 inactivates β1-integrin through binding to a membrane receptor [13] . Binding analysis by affinity labeling using biotinylated peptide FNIII14 detected a non-integrin membrane protein with a molecular mass of around 50 kDa ("p50") as a putative membrane receptor with specific binding activity to peptide FNIII14 [14]. ...
... Administration of peptide FNIII14 completely inhibited both the metastatic foci and the increases in liver and spleen weight. RGD peptide also inhibited the increases in liver and spleen weight, but only weakly, whereas peptide FNIII14 exhibited inhibitory effects at lower molar concentration compared with RGD peptide [28] . Moreover, transplantation of mouse mammary tumors into the ventral flank of mice caused liver metastasis, and peptide FNIII14 co-administered with doxorubicin suppressed these metastases. ...
... 28 Despite continued academic interest, however, the use of such RGD-peptides has not gained consensus for tissue regeneration or wound healing, possibly because other studies have indicated that, in specific contexts, RGD peptides may induce cell apoptosis as well as inflammation, and may inhibit angiogenesis. [34] [35] [36][37][38] We previously described a new family of haptotactic peptides (Haptides TM ) whose sequences are equivalent to sequences at or near the C-termini of fibrinogen b and c chains (peptides synthesized and identified as Cb and preCc respectively). 39 Mechanistic studies indicated that Haptides also augmented fibrin polymerization 40 and increased the transduction of liposomes directly into cells. ...
Department of Pharmaceutical Sciences
Join ResearchGate to find the people and research you need to help your work.
Tip: Most researchers use their institutional email address as their ResearchGate login
Tip: Most researchers use their institutional email address as their ResearchGate login
© 2008-2022 ResearchGate GmbH. All rights reserved.
Falls die Wiedergabe nicht in Kürze beginnt, empfehlen wir dir, das Gerät neu zu starten.
Melde dich an, um dein Alter zu bestätigen
Bei dem Versuch, Informationen zum Teilen abzurufen, ist ein Fehler aufgetreten. Versuche es bitte später noch einmal.
0:00 / 7:32 • Vollständiges Video ansehen Live
Für weniger Unterbrechungen Anzeigen direkt ansehen
Доступ к информационному ресурсу ограничен на основании Федерального закона от 27 июля 2006 г. № 149-ФЗ «Об информации, информационных технологиях и о защите информации».
На кресле около окна нагая кошка с отменным дуплом
Оттрахал после долгих прелюдий и ласк
Голые невесты в чулках