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Profilin was first described by Lars Carlsson in the lab of Uno Lindberg and co-workers in the early 1970s as the first actin monomer binding protein. [8] It followed the realization that not only muscle, but also non-muscle cells, contained high concentrations of actin, albeit in part in an unpolymerized form. Profilin was then believed to sequester actin monomers (keep them in a pro ...
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Anti-Profilin-1 Antibody, clone 1H21 ZooMAb® Rabbit Monoclonal
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Profilin-1 is a protein that in humans is encoded by the PFN1 gene. [5][6]
Profilins are small actin binding proteins, which are structurally conserved throughout evolution. They are probably best known to promote and direct actin p...
15 янв. 2026 г.
Profilin 1, or PFN1, is a key actin-binding protein that is involved in various cellular activities, such as cell motility, survival, and membrane trafficking. By summarizing the functions of PFN1 in cancer, investigators hope to better understand the mechanisms of PFN1 in cancer progression.
Profilins are small actin-binding proteins found in eukaryotes and certain viruses that are involved in cell development, cytokinesis, membrane trafficking, and cell motility. Originally identified as an actin sequestering/binding protein, profilin has been involved in actin polymerization dynamics. It catalyzes the exchange of ADP/ATP in actin and increases the rate of polymerization ...
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Profilins are small actin binding proteins, which are structurally conserved throughout evolution. They are probably best known to promote and direct actin polymerization. However, they also participate in numerous cell biological processes beyond ...
This is a simplified description of profilin proteins - there are more resources available at the bottom of the page for further reading for those who are interested in knowing more. What are profilin proteins? Many plant and animal tissues contain profilin proteins. They are small proteins involved in the assembly of actin filaments. Actin filaments in plants determine the shape and ...
Profilin is a ubiquitously expressed protein well known as a key regulator of actin polymerisation. The actin cytoskeleton is involved in almost all cellular processes including motility, endocytosis, metabolism, signal transduction and gene transcription. Hence, profilin's role in the cell goes bey …
6 дн. назад
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Actin-based structures in cells and tissues are built and maintained through a poorly understood balance between assembly and disassembly. Here, our findings provide insights into how factors ...
Fluorescently-tagged profilin-1 behaves similar to the tag-free protein in biochemical and cell-based assays.
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Conclusion Profilin 1 is a multifaceted protein that extends its regulatory functions beyond the cytoskeleton to influence fundamental cellular processes such as apoptosis and cell cycle progression. Its ability to interact with key signaling molecules like mutant p53 highlights its potential as a nexus for integrating cytoskeletal dynamics with cell fate decisions. Further research into the ...
The formins constitute a large class of multi-domain polymerases that catalyze the localization and growth of unbranched actin filaments in cells from yeast to mammals. The conserved FH2 domains ...
Chi and coworkers characterise proteins of Heimdallarchaeeota LC3, a member of the Asgard super phylum, and specifically investigate heim-Profilin and heim-Actin, and their interactions with ...
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Profilin release from the filament end controls the speed of actin growth at physiological conditions.
Profilin 1 is a crucial actin regulator, interacting with monomeric actin and several actin-binding proteins controlling actin polymerization. Recently, it has become evident that this profilin isoform associates with microtubules via formins and interferes with microtubule elongation at the cell periphery. Recruitment of microtubule-associated profilin upon extensive actin polymerizations ...
Profilin is a ubiquitously expressed protein well known as a key regulator of actin polymerisation. The actin cytoskeleton is involved in almost all cellular processes including motility, endocytosis, metabolism, signal transduction and gene transcription. Hence, profilin's role in the cell goes beyond its direct and essential function in regulating actin dynamics. This review will focus on ...
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REFINED SOLUTION STRUCTURE OF HUMAN PROFILIN I
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