Post Coupled

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U.S. Department of Energy
Office of Scientific and Technical Information
OSTI.GOV Technical Report: FIELD PERTURBATIONS IN THE POST COUPLED DRIFT TUBE LINAC.
FIELD PERTURBATIONS IN THE POST COUPLED DRIFT TUBE LINAC.
Authors:
Schneider, E J; Swenson, D A
Publication Date:
1969-10-31
Research Org.:
Los Alamos Scientific Lab., N. Mex.
OSTI Identifier:
4808290
Report Number(s):
BNL-50120(Pt.2)
NSA Number:
NSA-23-019059
Resource Type:
Technical Report
Resource Relation:
Other Information: UNCL. Orig. Receipt Date: 31-DEC-69
Country of Publication:
United States
Language:
English
Subject:
N34620* -Particle Accelerators-Auxiliaries & Components; DRIFT TUBES; ELECTROMAGNETIC FIELDS; LINEAR ACCELERATORS; MEASUREMENT; PERTURBATION THEORY; LINEAR ACCELERATORS/cavity resonators for, field perturbations in post-coupled drift tube; CAVITY RESONATORS/field perturbations in post-coupled drift tube linac
Schneider, E J, and Swenson, D A. FIELD PERTURBATIONS IN THE POST COUPLED DRIFT TUBE LINAC.. United States: N. p., 1969. Web.
Schneider, E J, & Swenson, D A. FIELD PERTURBATIONS IN THE POST COUPLED DRIFT TUBE LINAC.. United States.
Schneider, E J, and Swenson, D A. Fri . "FIELD PERTURBATIONS IN THE POST COUPLED DRIFT TUBE LINAC.". United States.
@article{osti_4808290,
title = {FIELD PERTURBATIONS IN THE POST COUPLED DRIFT TUBE LINAC.},
author = {Schneider, E J and Swenson, D A},
abstractNote = {},
doi = {},
url = {https://www.osti.gov/biblio/4808290}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1969},
month = {10}
}
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Similar records in OSTI.GOV collections:
Post couplers longitudinally stabilize the axial electric field in a drift-tube linac (DTL) against tuning errors. Displacing the post couplers toward one end of the structure results in a ramped field that increases toward the other end. Such a ramped-gradient DTL is also stable, but some of the cavity power is dissipated on the post couplers to maintain the ramp. This paper reports bead-perturbation measurements of the post-coupler magnetic fields near the tank well. A simple physical model reproduces the measured fields with an accuracy of about 2% and yields current-density distributions on the post couplers in terms of themore »
TECHNICAL REPORT
Jellett, K ; Parzen, G
CONFERENCE
KATONAK, D ; BERNARDIN, J ; HOPKINS, S
The Spallation Neutron Source (SNS) is a facility being designed for scientific and industrial research and development. SNS will generate and use neutrons as a diagnostic tool for medical purposes, material science, etc. The neutrons will be produced by bombarding a heavy metal target with a high-energy beam of protons, generated and accelerated with a linear particle accelerator, or linac. The low energy end of the linac consists of two room temperature copper structures, the drift tube linac (DTL), and the coupled cavity linac (CCL). Both of these accelerating structures use large amounts of electrical energy to accelerate the protonmore »
CONFERENCE
Katonak, D J ; Bernardin, J D ; Hopkins, S M
The Spallation Neutron Source (SNS) is a facility being designed for scientific and industrial research and development. SNS will generate and use neutrons as a diagnostic tool for medical purposes, material science, etc. The neutrons will be produced by bombarding a heavy metal target with a high-energy beam of protons, generated and accelerated with a linear particle accelerator, or linac. The low energy end of the linac consists of two room temperature copper structures, the drift tube linac (DTL), and the coupled cavity linac (CCL). Both of these accelerating structures use large amounts of electrical energy to accelerate the protonmore »

Anand Patwardhan, Norton Cheng and JoAnn Trejo
Pharmacological Reviews January 2021, 73 (1) 120-151; DOI: https://doi.org/10.1124/pharmrev.120.000082
G protein–coupled receptors (GPCRs) are a large family comprising >800 signaling receptors that regulate numerous cellular and physiologic responses. GPCRs have been implicated in numerous diseases and represent the largest class of drug targets. Although advances in GPCR structure and pharmacology have improved drug discovery, the regulation of GPCR function by diverse post-translational modifications (PTMs) has received minimal attention. Over 200 PTMs are known to exist in mammalian cells, yet only a few have been reported for GPCRs. Early studies revealed phosphorylation as a major regulator of GPCR signaling, whereas later reports implicated a function for ubiquitination, glycosylation, and palmitoylation in GPCR biology. Although our knowledge of GPCR phosphorylation is extensive, our knowledge of the modifying enzymes, regulation, and function of other GPCR PTMs is limited. In this review we provide a comprehensive overview of GPCR post-translational modifications with a greater focus on new discoveries. We discuss the subcellular location and regulatory mechanisms that control post-translational modifications of GPCRs. The functional implications of newly discovered GPCR PTMs on receptor folding, biosynthesis, endocytic trafficking, dimerization, compartmentalized signaling, and biased signaling are also provided. Methods to detect and study GPCR PTMs as well as PTM crosstalk are further highlighted. Finally, we conclude with a discussion of the implications of GPCR PTMs in human disease and their importance for drug discovery.
Significance Statement Post-translational modification of G protein–coupled receptors (GPCRs) controls all aspects of receptor function; however, the detection and study of diverse types of GPCR modifications are limited. A thorough understanding of the role and mechanisms by which diverse post-translational modifications regulate GPCR signaling and trafficking is essential for understanding dysregulated mechanisms in disease and for improving and refining drug development for GPCRs.
This work is supported by the National Institutes of Health National Institute of General Medical Sciences [Grants R35 GM GM127121, T32 GM007752] and the University of California, Tobacco-Related Disease Research Program Postdoctoral Award [T31FT1574].
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Anand Patwardhan, Norton Cheng and JoAnn Trejo
Pharmacological Reviews January 1, 2021, 73 (1) 120-151; DOI: https://doi.org/10.1124/pharmrev.120.000082
Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics

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Post Coupled