Plasmablastic lymphoma maxillo facial surgery

Plasmablastic lymphoma maxillo facial surgery
Apr 8, 2025
Abstract Objective: The purpose of the current study was to report on the clinical presentation and radiological features of 72 cases of oral and maxillofacial plasmablastic lymphomas (PBL). Methods: Histologically confirmed cases of PBL were retrospectively reviewed over a 10-year period.
Plasmablastic lymphoma (PBL) is recognized as a study reported a relatively higher proportion of Blacks (17%) and CD20-negative aggressive non-Hodgkin lymphoma (NHL) by the World Health Organization Classification of Lymphomas.2
Plasmablastic lymphoma is a rare B-cell lymphoma with poor prognosis, most frequently occurring in the oral cavity and mainly affecting immunocompromised patients.
Keywords: Plasmablastic lymphoma, PBL, HIV-negative, Maxillary sinus Introduction Plasmablastic lymphoma (PBL) is a recently recognized aggressive non-Hodgkin's B-cell lymphoma which occurs predominantly in HIV seropositive individuals and shows a predilection for the oral cavity.
Plasmablastic lymphoma is a rare and rapidly progressive vari-ety of diffuse large B-cell lymphoma with male predominance, originally reported exclusively in the jaw and oral mucosa of immunosuppressed individuals.1At the time of writing, the authors are aware of 4 reported cases of PBL arising in the maxillary sinus in immunocompetent patients.
Plasmablastic lymphoma is a rare aggressive variant of large B-cell lymphoma with distinct clinical and prognostic implications, but it shows overlapping phenotypic characteristics with other lymphoid neoplasms. Relevant clinical, morphologic, and immunophenotypic features are presented, along with a review of the literature.
Plasmablastic lymphoma (PBL) is an aggressive, fast-growing hematolymphoid neoplasm occurring most commonly in the head and neck region [1, 2]. PBL is classified as a subtype of non-Hodgkin lymphoma, being first described as a distinct entity in 1997 by Delecluse et al. [3].
May 1, 2025
These findings may assist clinicians in the clinical diagnostic work-up of patients, including the acquisition and assessment of appropriate advanced radiographic imaging. Keywords Maxillofacial pathology · Maxillofacial radiology · Malignant neoplasms · Lymphomas · Plasmablastic lymphomas
Dec 16, 2024
Plasmablastic lymphoma (PBL) is a rare and aggressive type of non-Hodgkin lymphoma that in 2000 was classified as a distinct type of lymphoma related to acquired immune deficiency syndrome by the World Health Organization after the first reports of the disease surfaced in 1997. PBL is strongly associated with human immunodeficiency virus (HIV) infection and often occurs within the oral cavity ...
Plasmablastic lymphoma (PBL) is a rare and aggressive variant of diffuse large B-cell lymphoma (DLBCL). It is a recently described variant of non-Hodgkin's lymphoma that occurs almost exclusively in human immunodeficiency virus (HIV) infection, in the post-transplant setting and in other immunosuppressive states.
Background: Plasmablastic lymphoma (PBL) is a rare, aggressive neoplasm that most commonly occurs in immunodeficient patients. The most common site of PBL is the oral cavity and the prognosis is poor. Spontaneous regression of malignant lymphoma is extremely unusual. Here, we report a spontaneous regression of PBL in the upper gingiva without any treatment.
Report of a Case The patient is a 35-year-old man with a past medical history significant for HIV infection who was referred to our department (Oral and Maxillofacial Surgery, MetroHealth Medical Center, Cleveland, OH) in May 2005 from an outside facility with what was described as an odontogenic infection of the left maxilla.
Plasmablastic lymphoma (PBL) is an aggressive, fast-growing hematolymphoid neoplasm occurring most commonly in the head and neck region [1,2]. PBL is classified as a subtype of non-Hodgkin lymphoma, being first described as a distinct entity in 1997 by Delecluse et al [3].
Mar 1, 2024
Sep 30, 2025
Plasmablastic lymphoma (PBL) of the oral cavity is an uncommon, recently described B-cell derived lymphoma that is most commonly seen in patients with human immunodeficiency virus (HIV) infections. The authors report a rare case of PBL in the oral cavity of a 40-year-old man with HIV. The lymphoma cells were positive for leukocyte common antigen, CD79a, CD138, Epstein-Barr virus (EBV) and ...
The plasmablastic lymphoma, belonging to the diffuse large B-cell lymphoma family, is a very aggressive and unusual form of cancer with poor prognosis. If it is found mainly in patients with positive HIV, in whom it was first described, it is also found in immunosuppressed patients such as transplanted patients or patients suffering from leukaemia.
We report 3 cases of neoplasms with plasmablastic histomorphology involving the oral cavity. The relevant clinical, morphologic, and immunophenotypic features and treatment are presented, along with a review of the literature.
Plasmablastic lymphoma is a rare, AIDS-related, non-Hodgkin lymphoma with a noticeable predilection for the oral cavity [13]. This entity was first described by Delecluse et al. [14]. It carries a dismal prognosis with an average survival time of 6 months after diagnosis. At 13 months after diagnosis, our patient is still alive.
Background: Plasmablastic lymphoma (PBL) is an aggressive neoplasm that commonly develops in HIV-positive patients, usually affecting the oral cavity. EBV is present in the majority of cases, therefore, playing an important role in the pathogenesis of this neoplasm. Methods: PBL diagnosed from 2000 to 2020 were retrieved from the archives of the Department of Oral Pathology and Oral Biology at ...
Jan 1, 2025
A case of oral plasmablastic lymphoma and review of current trends in oral manifestations associated with human immunodeficiency virus infection. Journal of Oral and Maxillofacial Surgery. 2014;72(9):1729-1735. doi: 10.1016/j.joms.2014.04.009.
In this case, the diagnosis of lymphoma was done lately because of the lack of specificity of plasmablastic presentation and because of the presence of other oral lesions related to osteoradionecrosis and radiotherapy adverse effects.
A new surgery with peripheral osteotomy was performed, and the patient is being followed up.ORAL PLASMABLASTIC LYMPHOMA DIAG- NOSIS AND TREATMENT FOLLOW-UP: CASE REPORT Thales Felipe Dos Santos De Oliveira, Felipe Rachi Ludvig, Felippe Jos e Almeida Loureiro, Wictor Nogueira Rodrigues, Raquel Bittencourt, Marco Antonio Trevizani Martins, and ...
Plasmablastic lymphoma (PBL) is an aggressive type of large B-cell lymphoma as stated in the WHO classification of 2008. It is a rare form of non-Hodgkin's lymphoma, generally seen in human immunodeficiency virus (HIV)-acquired immunodeficiency syndrome ...
Plasmablastic lymphoma (PBL) is an uncommon and aggressive large B-cell lymphoma commonly diagnosed in human immunodeficiency virus-positive patients. Though the oral cavity is a common site for PBL, this condition is not commonly reported in the literature as an oral manifestation.
Abstract Read online Plasmablastic lymphoma (PBL) is a highly aggressive variant of diffuse large B-cell lymphoma and is usually treated by chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP-like regimens. However, elderly patients tend to have difficulty with the chemotherapy. We successfully treated an HIV-negative elderly PBL patient with surgery ...
Conclusion: High-grade oral lymphomas are more associated with destructive presentation than low-grade subtypes, and bilateral lesions in the palate are more associated with a lymphoma diagnosis ...
Plasmablastic lymphoma is an aggressive subtype of non-Hodgkin lymphoma associated with acquired immune deficiency syndrome. We report the case of a 30-year-old woman complaining of a growth adjacent to the wisdom tooth. She reported tobacco and alcohol consumption and to testing positive for HIV. The lesion had an onset of 3 months prior to consultation and was painful. Clinically, a hard ...
Plasmablastic lymphoma is a rare subtype of non-Hodgkin's lymphoma, which generally presents an aggressive clinical course and low survival rates. It is strongly associated with HIV infection and the most common site of involvement of the territory ...
Background Plasmablastic lymphoma (PBL) is a high-grade lymphoma that often affects the oral cavity of HIV-positive patients; however, its prognostic determinants remain unknown. Purpose To integrate the available data on oral PBL to determine its clinicopathological features and to identify potential prognostic factors. Methods An electronic systematic review was performed using multiple ...
Plasmablastic lymphoma (PBL) is a rare and aggressive variant of diffuse large B‐cell lymphoma (DLBCL). It is a recently described variant of non‐Hodgkin's lymphoma that occurs almost exclusively in human immunodeficiency virus (HIV) infection, in the post‐transplant setting and in other immunosuppressive states.
Abstract Plasmablastic lymphoma is a rare subcategory of non-Hodgkin lymphoma frequently associated with human immunodeficiency virus. It is a large B-cell lymphoma that has a predilection for the oral cavity. Clinically, plasmablastic lymphoma may mislead to a diagnosis of Kaposi's sarcoma. When infected, plasmablastic lymphoma may mimic an odontogenic cellulitis. Epstein-Barr virus and human ...
Jun 1, 2024
Dec 16, 2024
Table 1. Demographics, clinical features, management, and outcomes of plasmablastic lymphoma cases identified at the University of Texas Southwestern Medical Center and the Parkland Health and Hospital System over a 10-year period
Statement of Clinical Relevance Acute lymphoblastic leukemia/lymphoma is an aggressive malignancy that very rarely affects the oral and maxillofacial region; therefore, oral pathologists must be aware of its microscopic and immunohistochemical features to achieve the correct diagnosis.
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Plasmablastic lymphoma is a rare B-cell lymphoma with poor prognosis, most frequently occurring in the oral cavity and mainly affecting immunocompromised patients.
Jun 1, 2024
Plasmablastic lymphoma (PBL) is a rare aggressive variant of large B cell lymphoma defined as a proliferation of large neoplastic plasmoblasts [9]. PBLs in immunocompromised patients, like transplanted [10] or HIV-positive patients, show a predilection for the oral cavity, although extra-oral involvement is found [11].
Plasmablastic lymphoma is a frequent diagnosis in South Africa, due to the country's HIV burden, where it usually affects the oral cavity and is always associated with EBV-infection.
Plasmablastic lymphoma (PBL) is a highly aggressive B cell non-Hodgkin lymphoma frequently associated with immunosuppression, particularly human immunodeficiency virus (HIV) infection. Although PBL is rare globally, South Africa has a high burden of HIV infection leading to a higher incidence of PBL in the region. Laboratory features in PBL may overlap with plasmablastic myeloma and other ...
This study aimed to collaboratively report the incidence of malignant lymphoid neoplasms of the oral and maxillofacial region according to the experience of the two oral and maxillofacial pathology biopsy services in dental schools in the State of North Carolina.
Abstract Background: Plasmablastic lymphoma (PBL) is a high-grade lymphoma that often affects the oral cavity of HIV-positive patients; however, its prognostic determinants remain unknown. Purpose: To integrate the available data on oral PBL to determine its clinicopathological features and to identify potential prognostic factors.
Plasmablastic lymphoma (PBL) is a rare variant of large diffuse B-cell non-Hodgkin lymphoma with predilection for extranodal localization in the oral cavity. A 43-year-old HIV-positive female patient attended a stomatology service for evaluation of a painful oral mass with 6 months of duration. At the extraoral examination, swelling in the left hemiface and facial increased lymph nodes were ...
Plasmablastic lymphoma (PBL), a rare subtype of large B-cell lymphoma, is an uncommon aggressive malignancy that is associated with patients with HIV or other immunosuppression, and it tends to arise in the oral cavity. The recent WHO classification of lymphoid neoplasms as a separate entity under mature B-cell neoplasms is noteworthy. It accounts for 2.6% of all HIV-associated non-Hodgkin ...
The quality of the majority of images was sufficient for evaluation. Diffuse large B-cell lymphoma, Burkitt lymphoma, leukemic infiltration, plasmablastic lymphoma and extranodal Natural killer (NK)/T-cell lymphoma, nasal type were the most common subtypes.
Plasmablastic Lymphoma is rare and aggressive variant of non-Hodgkins Lymphoma which generally manifests itself in patients with immunosuppression, predominantly associated with the human immunodeficiency virus and in the majority with Epstein-Barr virus (EBV) infection. Male patient, 67 years old had referred for evaluation of a persistent lesion after endodontic treatment on teeth 26 and 27 ...
Oral plasmablastic lymphoma (PBL) is a rare malignancy, associated with HIV or other immunocompromised conditions. The lesion constituted a new subtype of diffuse large B-cell lymphoma and proposed a distinct entity based on its basic morphology, ...
In view of these findings a definitive diagnosis of plasmablastic lymphoma was instituted. The patient was referred to the hematology department to start the chemotherapy. At present, clinical examination shows complete regression of the lesion. The patient awaits onset of radiotherapy and possible hematopoietic stem cell transplant.
Introduction: Plasmablastic lymphoma (PBL) is an uncommon and aggressive large B-cell lymphoma commonly diagnosed in human immunodeficiency viruses -positive patients. Oral cavity is the most commonly PBL affected site. Most oral PBLs presented as asymptomatic swellings, frequently associated with ulcerations and bleeding. Most cases lacked B-symptoms, suggesting a more local involvement of ...
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