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Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. Mescaline occurs naturally in the peyote cactus Lophophora williamsii , \\\\\\\\\\\\\[2\\\\\\\\\\\\\] and it is produced in a number of other cacti species such as the Echinopsis pachanoi San Pedro cactus , \\\\\\\\\\\\\[3\\\\\\\\\\\\\] Echinopsis peruviana Peruvian Torch as well as the Cactaceae plant and the Fabaceae bean family. Unlike most highly prohibited substances, mescaline is not considered to be addictive by the scientific community. This History and Culture section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. The ritual use of the Peyote cactus has occurred for at least years by Native Americans in Mexico. Upon early contact, Europeans noted the use of Peyote in Native American religious ceremonies. Additionally, alternative mescaline-containing cacti such as the San Pedro have a long history of use in the South American continent, spanning from Peru to Ecuador. In modern times, users will often grind it into a powder and pour it into gel capsules to avoid having to come into contact with the bitter taste of the cactus. The usual human dose is — milligrams of mescaline sulfate or — milligrams of mescaline hydrochloride. Mescaline, or 3,4,5-trimethoxyphenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino -NH 2 group through an ethyl chain. Mescaline contains three methoxy functional groups CH 3 O- which are attached to carbons R 3 , R 4 , and R 5 of the phenyl ring. Mescaline acts similarly to other psychedelic agents. The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely if ever occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death. The visual geometry encountered on mescaline can be described as similar in appearance to that of ayahuasca , 2C-P or psilocin in the sense that its geometry is structured in its organization as well as natural and organic in style. Mescaline is capable of producing a full range of high-level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. Anecdotal reports which describe the effects of this compound within our experience index include:. The toxicity and long-term health effects of recreational mescaline use does not appear to have been studied in any scientific context and the exact toxic dose is unknown. However, there are no known fatal overdoses within the scientific literature. Anecdotal reports suggest that there are no negative health effects attributed to simply trying mescaline by itself at low to moderate doses and using it very sparingly but nothing can be completely guaranteed. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this substance. Mescaline is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating. Tolerance to the effects of mescaline are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline in the absence of further consumption. Mescaline presents cross-tolerance with all psychedelics , meaning that after the consumption of mescaline all psychedelics will have a reduced effect. Although many psychoactive substances are safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The following lists some known dangerous combinations, but may not include all of them. A combination that appears to be safe in low doses can still increase the risk of injury or death. Independent research should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from Tripsit. From PsychonautWiki. Jump to: Summary sheet: Mescaline Mescaline. Further information: Serotonergic psychedelic. Physical effects. Visual effects. Cognitive effects. Auditory effects. Multi-sensory effects. Transpersonal effects. See also: Psychedelics, April , — Grand Junction, CO: Amera-Chem, Inc. ISBN X. Erowid Online Books: Retrieved April 14, The Mechanistic Classification of Addictive Drugs, 3 Adverse reactions to psychedelic drugs. A review of the literature. The Journal of Nervous and Mental Disease , 10 , Handbook of Overdose and Detoxification Emergencies. New Hyde Park, NY.: Medical Examination Publishing Company. Mescaline derivatives. Visionary Cactus Guide - Mescaline from Sawdust'. Retrieved 14 January Retrieved All articles with unsourced statements Articles with unsourced statements Psychoactive substance Entheogen Hallucinogen Naturally-occurring Phenethylamine Psychedelic. Navigation menu Personal tools Create account Log in. Namespaces Page Discussion. Views Read View source View history. Community Network YouTube Good vibes.
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