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↑ Gagnon A & Wilson RD. (2008). Obstetrical complications associated with abnormal maternal serum markers analytes. J Obstet Gynaecol Can , 30 , 918-932. PMID: 19038077 DOI .
↑ Kristensen T, Oxvig C, Sand O, Møller NP & Sottrup-Jensen L. (1994). Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA. Biochemistry , 33 , 1592-8. PMID: 7508748
↑ Haaning J, Oxvig C, Overgaard MT, Ebbesen P, Kristensen T & Sottrup-Jensen L. (1996). Complete cDNA sequence of the preproform of human pregnancy-associated plasma protein-A. Evidence for expression in the brain and induction by cAMP. Eur. J. Biochem. , 237 , 159-63. PMID: 8620868
↑ Overgaard MT, Sorensen ES, Stachowiak D, Boldt HB, Kristensen L, Sottrup-Jensen L & Oxvig C. (2003). Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment. J. Biol. Chem. , 278 , 2106-17. PMID: 12421832 DOI .
This page was last modified on 19 March 2018, at 23:49.
Pregnancy-associated plasma protein-A (PAPP-A) largest of the pregnancy associated proteins produced by both the embryo and the placenta ( syncytiocytotrophoblasts ) during pregnancy (Placenta Notes). This protein is thought to have several different functions, including preventing recognition of the fetus by the maternal immune system, matrix mineralization and angiogenesis. Levels of PAPP-A rise from first detection in the first trimester until term.
Detection of this protein is also suggested as a first and second trimester diagnostic test for aneuploidies, including Trisomy 21 or Down Syndrome .
Maternal serum concentrations are related to subsequent fetal growth and this relationship has suggested that it can be used as a diagnostic test for adverse pregnancy outcomes (intrauterine growth restriction, premature birth, preeclampsia, and stillbirth).
Alternative names: pappalysin 1, PAPP-A, PAPPA1, SP4, high molecular weight alpha-2 mobile pregnancy-specific protein, IGFBP4 protease (IGFBP-4ase), ASBABP2, DIPLA1, PAPA
Cite this page: Hill, M.A. (2022, August 24) Embryology Pregnancy-associated plasma protein-A . Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Pregnancy-associated_plasma_protein-A
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