PEGylation Based Half-Life Extension Service

PEGylation, a very popular technology for the modification of proteins, was introduced in the early 70s. The peptide chain is covalently attached to one or more high molecular weight chains of PEG, a molecule built of repetitive units of ethylene oxide (CH2-CH2-O). This elongation works by hiding antigenic determinants of the peptide so that antibodies cannot recognize it as a foreign body, and increasing protein size so that it won't be cleared out by kidneys very easily. PEG itself is an uncharged hydrophilic polymer that is non-biodegradable, mostly non-toxic, and non-immunogenic. Highly flexible PEG molecules can be easily attached to a therapeutic molecule. PEGylation also helps absorption enhancement by making the proteins more water-soluble and masks the molecules from proteolytic degradation.

Learn more: PEGylation Based Half-Life Extension Service