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Click here to learn how to Microdose! The San Pedro cactus Echinopsis pachanoi and Echinopsis peruvianus is a fast-growing cactus native to the Andes region in South America. Mescaline is a relatively safe substance that has extraordinary properties in high doses and can also be a wonderful substance for microdosing. Indigenous peoples in Mexico and South America have been using San Pedro and peyote for ceremonial and ritual purposes for over years. The Huichol tribe of Mexico, for example, believes that the cactus has healing properties. Europeans discovered peyote after Spain conquered Mexico in the early sixteenth century. Attempts to suppress its use, predominantly by missionaries, were unsuccessful. In fact, after being forced into reservations, peyote rituals spread further to Native Americans of the plains in the United States, such as the Osage Nation. Mescaline was isolated from peyote for the first time in by the German chemist Arthur Heffter. It played an essential role in the work of the American chemist Alexander Shulgin, who used it as a starting point for synthesizing several new psychedelic substances. Unfortunately, mescaline was never thoroughly researched for its potential therapeutic effects because in the s research abruptly shifted to LSD —a synthesized psychedelic with similar attributes but fewer side effects. Only medical and scientific research with mescaline in humans is allowed under the UN Convention, but research with psychedelics proves incredibly difficult in practice. Even though mescaline is illegal, the psychoactive plants which contain mescaline are legal or decriminalized in many countries including the Netherlands and the United Kingdom. Therefore, you can obtain these plants from plant shops and garden centers or specialized vendors of mescaline-containing cacti. San Pedro, however, is widely available and not at risk of extinction, which is why when it comes to microdosing with mescaline, we strongly recommend microdosing San Pedro over other mescaline containing cacti. Learn more about the ethical use of plant medicines here. Mescaline cacti are peeled and boiled into a juice or dried and then consumed. The taste can be very bitter, but one way to dispel the bitter taste is to drink pineapple juice or grapefruit juice while chewing. A high dose of mescaline is between milligrams to milligrams and from this type of cactus it induces a peaceful, colorful, warm, mystical state of being. San Pedro has a milder effect than peyote because peyote contains additional alkaloids. Mescaline is widely regarded as one of the most gentle, insightful, and euphoric psychedelics. It emphasizes bodily and tactile sensations more than psychedelic tryptamines such as psilocybin or DMT, which have a more intense headspace and dynamic visual geometry. Because of its mellow, organic, yet complex nature, people see high potential in the use of mescaline in psychedelic therapy. Mescaline, short for 3,4,5-Trimethoxyphenethylamine, is part of the phenethylamines class, which includes MDMA and several antidepressants. Like many other psychedelic substances, including LSD and psilocybin , it binds to the serotonin receptors in the brain. Researchers are still searching to explain how this leads to a psychedelic experience when consuming these substances. That means that at some point you need a higher dose to feel the same effect. However, adverse psychological reactions can happen to people predisposed to the following psychological or psychiatric disorders:. Some possible risks occur when combining several safe substances. The following list includes contraindicated combinations with mescaline, although this might not be exhaustive. We suggest avoiding combining substances when microdosing San Pedro. Currently, little is known about microdosing San Pedro; however, we have collected several anecdotal stories from community members and combined them with our own experience to come up with three important observations:. The single most important reason these cacti are not a popular trip drug by themselves is that mescaline can vary significantly from one cactus to another. This depends, among other things, on the species, the age, and the place of growth of the cactus, which makes accurate dosing a challenge. Therefore, we advise buying your San Pedro cactus from a specialist. Our partner shop, Microdose. Each cactus has a different mescaline content. An average microdose of dried San Pedro cactus is between 1. Mix everything you have left into a paste. This will ensure that the mescaline will be evenly distributed throughout your whole batch of San Pedro. Put the San Pedro in a boil and leave it to dry. To speed up the process, direct a fan onto the San Pedro paste. When everything is crispy dry, you can grind everything into a fine powder. This works best using an electric coffee grinder. To make microdosing San Pedro as effortless as possible, you could encapsulate the powder and prepare your microdoses ahead of time. NOTE: Remember to remove the weight of an empty capsule from the total weight. To find out which dose is your sweet spot, start with the lowest dose 1 capsule of 0. If you feel this microdose is too low, take a higher dose the next microdosing day 2 capsules for a total of 1. For more in-depth information, read our guide on how to microdose. NOTE: Keep in mind that this is a rough indication. The potency of each batch depends on the size of the cacti, their potency, and the amount of flesh you cut and use from the cactus. This means that each time you dry the cacti, you then have to find your sweet spot for this specific batch. A good rule of thumb is; the whiter flesh, the weaker the potency. After determining your sweet spot, you can get started with microdosing San Pedro. We advise microdosing once every three days following the Fadiman protocol. The process of drying, powdering, and encapsulating is not very difficult, but it takes a little dedication and patience. Processing psychedelics like San Pedro is not legal in the Netherlands and many other countries. If you want to start microdosing mescaline right away, an unregulated synthetic analog is currently available in most countries in the European Union. EN NL. Microdosing San Pedro mescaline. Table of Contents. History of the San Pedro cactus. Legality of the San Pedro cactus. Effects of San Pedro at high doses. Mental effects at high doses Change of perception—seeing things more colorful and intense. Things take on contours, distort or emit light. Distortion of time Distortion of space Synesthesia—mixing of sensory perceptions such as seeing music, hearing an image, or smelling colors Euphoria Mood sensitivity—one moment someone is feeling euphoria, the next to go into an anxious mood Profound insights Losing touch with reality Magical or religious experiences Physical effects at high doses Increased heart rate Increased blood pressure Slight acceleration of the breathing Excessive salivation Increased body temperature and sweating may alternate with chills and tremors Mescaline is widely regarded as one of the most gentle, insightful, and euphoric psychedelics. Pharmacology of mescaline. However, adverse psychological reactions can happen to people predisposed to the following psychological or psychiatric disorders: Anxiety Paranoia Delusion Psychosis Possible negative physical side effects include: Nausea Diarrhea Abdominal cramps Some possible risks occur when combining several safe substances. Microdosing San Pedro. Currently, little is known about microdosing San Pedro; however, we have collected several anecdotal stories from community members and combined them with our own experience to come up with three important observations: Microdosing San Pedro requires more preparation than microdosing magic truffles or microdosing magic mushrooms The amount of mescaline is frequently unknown, as it varies depending on the harvest and even cactus. If microdosing magic mushrooms makes you restless, microdosing San Pedro can be an excellent alternative The average dosages for microdosing dry San Pedro are: Low microdose: 1. Effects of microdosing San Pedro. Slow onset: it takes about 1. Risks of microdosing San Pedro. Ready to shop for San Pedro? Shipping within the European Union only. Shop now. How to prepare your dose for microdosing with San Pedro. Preparing the San Pedro cactus. Before starting to process the San Pedro cactus, remove the spikes with a pair of scissors to prevent any damage to your skin. The most effective way of doing this is to cut with an angle of 45 degrees on each side of the spikes and take them out with your hand. There are not that many, and the spikes are quite evenly distributed, so this is relatively easy Cut the San Pedro cactus in four even parts in the longitudinal direction. Then cut the inner parts out of the peel. Boiling the San Pedro cactus. Put milliliters of water in a pan and put it on the stove. Boil it for approximately 20 minutes until the flesh is soft. Remove the outer layer when everything is boiled soft. Scrap the cactus off from the peel with the knife. Mix the San Pedro. Dry the San Pedro. Grind the San Pedro. Encapsulate the powered San Pedro. Finding your sweet spot for microdosing San Pedro. Start microdosing San Pedro. Another option for microdosing mescaline. Your story is powerful Your experience can help orient other microdosers, and benefit the community at large. Consider taking a couple of minutes to write down your experiences with microdosing positive or negative. Share your story. Heffter, A. PLOS Medicine. About Microdosing What is microdosing? Benefits of Microdosing Dr. Facebook Youtube Instagram Linkedin. Subscribe to our newsletter:. Privacy policy.

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