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Full clinical effectiveness is generally reached after 10 weeks of treatment. Zaditen is a prophylactic agent to be used on a continuous basis and is not effective in the acute prevention or treatment of acute asthma attacks. Patients sensitive to benzoate compounds should not take Zaditen syrup. It is therefore recommended that for patients not adequately responding within a few weeks, treatment with Zaditen should be maintained for a minimum of 2 to 3 months. Zaditen may have an anti-inflammatory effect in the lungs and the time of onset of clinical efficacy may reflect the recovery period of the lungs from inflammation.Symptomatic and prophylactic antiasthmatic drugs (xanthine derivatives, b2-agonists, sodium cromoglycate, corticosteroids) already in use should not be reduced immediately when treatment with Zaditen is initiated. Continuous use of Zaditen may reduce the frequency, severity and duration of asthmatic symptoms or attacks, and lead to a reduction in daily requirements of concomitant antiasthmatic medication, like theophyllines and b2-agonists. Zaditen tablets are benzoate-free and can be administered alternatively to such patients. This applies especially to systemic corticosteroids and ACTH injections because of the possible existence of adrenocortical insufficiency in steroid-dependent patients; in such cases recovery of a normal pituitary-adrenal response to stress may take up to one year.Hypersensitivity to Zaditen or any other components of the formulations.Since drowsiness may occur in the early stages of therapy, patients engaging in activities requiring rapid and precise responses should be cautioned. Zaditen syrup should not be administered to patients sensitive to benzoate compounds. Symptoms of asthma may recur. Thrombocyte counts should therefore be carried out in patients taking oral antidiabetic agents concomitantly.A reversible fall in the thrombocyte count in patients receiving Zaditen concomitantly with oral antidiabetic agents has been observed in rare cases.Zaditen may potentiate the effects of sedatives, hypnotics, antihistamines and alcohol.Several weeks of Zaditen therapy may be necessary before the therapeutic effect becomes clinically evident. In diabetic patients, the carbohydrate content of the syrup (5 mL: 4 g carbohydrate) should be taken into consideration. If it is necessary to withdraw Zaditen, this should be done progressively over a period of 2 to 4 weeks. WV, Oregon, Kansas City, Seattle, Montana, MS, NM, AR, Las Vegas, Missouri, Tulsa, Pennsylvania, Milwaukee, Michigan, Colorado, San Francisco, Alaska, NE, Maryland, MT, AL, Indianapolis, Kansas, Maine, HI, AZ, Rhode Island, Illinois, Texas, Atlanta, DC, Pennsylvania, Nebraska, ID, Delaware, Wyoming, Portland, Brookhaven, Hempstead, IA, New Hampshire, New Jersey, Nebraska, NV, MD, Baltimore, Fort Worth, Phoenix, MO, Minnesota, ND, Dallas, Massachusetts, Florida, Virginia, TX, Virginia Beach, Hawaii, Idaho, Honolulu, South Dakota, Fresno, San Diego, Wisconsin, Long Beach, OR, California, FL, OK, Florida, UT, Oakland, LA, San Jose, New York, MN, Missouri, TN, WYAlabama, Maryland, OH, SC, Columbus, North Carolina, Arkansas, NJ, Ohio, Nashville-Davidson, IN, New Mexico, GA, Iowa, Oklahoma, Mississippi, Colorado, MA, Nevada, CA, RI, IL, CO, Albuquerque, Nevada, NY, Connecticut, Indiana, Georgia, Arizona, NH, AK, Colorado Springs. Arizona, District of Columbia, Memphis, Virginia, Houston, Minneapolis, West Virginia, Indiana, Minnesota, Detroit, Louisiana, Illinois, Oklahoma City, Washington, Miami, KY, Tennessee, California, Ohio, Los Angeles, Kentucky, District of Columbia, El Paso, SD, North Dakota, KS, New Mexico, Michigan, Utah, Jacksonville, Washington, Cleveland, Massachusetts, San Antonio, Oklahoma, Chicago, CT, VA, North Carolina, New Orleans, NC, Denver, Vermont, PA, WI, Boston, WA, Texas, Charlotte, VT, Tennessee, Mesa, Austin, MI, Washington, South Carolina, Hawaii, Omaha, Tucson, Oregon, New York, Georgia, ME, Wisconsin, NY, Sacramento, DE, Philadelphia, Louisiana,