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Kidnely failure does not require a dosage correction while liver failure requires usage of other beta-adrenoblockers which are not destructed in liver. Topme influences autonomic nervous system which stipulates increased heart rate by blocking its receptors and thus reducing abnormally rapid heart rhythms.At the background of common tolerance to the Topme among side effects are noticed abdominal cramps, fatigue, insomnia, nausea, depression, memory loss, fever, impotence, lightheadedness, slow heart rate, low blood pressure, cold extremities, sore throat, diarrhea, constipation, and shortness of breath or wheezing.Topme should be taken with food or just after a meal. It also diminishes myocard irritability, cardiac output and causes other effects. Do not try to compensate a missed dose by taking an extra one. Do not chew, squash or break a tablet, drink a glass of water with it. Dosage depends on the treated disease and may vary between 100-450 mg daily. Your individual dosage should be prescribed by your physician. Topme acts mostly blocking beta-adrenoreceptors of the heart and is used to treat hypertension, chest pain (angina), abnormal rhythms of the heart, to treat and prevent myocardial infarction. Aged patients are recommended to start from 50 mg daily dose. Take the forgotten dose as soon as you remember.If you notice such symptoms as uneven heartbeats, shortness of breath, dizziness, weakness or fainting, bluish-colored fingernails, seek for immediate medical help. If your next dose is less than 4 hours away, skip it and return to your schedule. Memphis, Missouri, ID, NV, WYIowa, Hawaii, Minneapolis, Texas, Seattle, South Carolina, Michigan, NM, Detroit, Fort Worth, Boston, OH, Miami, Kansas City, Kentucky, Nebraska, IL, Missouri, Oregon, KS, Wyoming, Florida, Atlanta, Vermont, Louisiana, AZ, California, OK, Ohio, San Jose, AL, Baltimore, Minnesota, Brookhaven, CO, Washington, Oklahoma, Arkansas, NC, MD, Long Beach, CT, Georgia, Jacksonville, Colorado Springs. Arizona, North Carolina, Mississippi, Ohio, New York, Sacramento, Delaware, LA, NE, Milwaukee, Los Angeles, Indiana, Nashville-Davidson, Nebraska, Colorado, Minnesota, Virginia, PA, Washington, WI, Massachusetts, Houston, DE, Indianapolis, NH, MI, New Mexico, Washington, TX, Fresno, AK, DC, NJ, Charlotte, MN, California, North Dakota, MS, RI, Albuquerque, Idaho, Pennsylvania, Oregon, Virginia Beach, New Orleans, Cleveland, Rhode Island, San Antonio, Omaha, Portland, Maryland, Wisconsin, Austin, IN, CA, Illinois, Utah, MA, Hempstead, Tennessee, SD, Alaska, New Jersey, Indiana, MT, GA, IA, Phoenix, Nevada, Chicago, VT, New York, Wisconsin, Tulsa, AR, SC, Maine, Georgia, TN, Hawaii, OR, Massachusetts, VA, New Mexico, UT, San Francisco, Pennsylvania, Tucson, Maryland, Alabama, NY, Denver, Illinois, Florida, Michigan, Oklahoma City, Columbus, South Dakota, HI, Montana, ME, ND, Texas, Mesa, District of Columbia, Kansas, Arizona, WA, Dallas, MO, New Hampshire, KY, Oklahoma, Connecticut, Colorado, District of Columbia, Louisiana, WV, NY, FL, San Diego, Oakland, Honolulu, Las Vegas, Tennessee, Virginia, Philadelphia, Nevada, West Virginia, El Paso, North Carolina,