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Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume, with consequent increases PRA, increases in aldosterone secretion, increases in urinary potassium loss, and decreases in serum potassium.Telmisartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland.The common side effects of Cresar H: diarrhea, headache, vomiting, nausea, chest congestion, fatigue, body and muscle aches. If you have an allergy to this medicine, you will experience symptoms such as swelling of the tongue, throat or face, rashes, itchiness and difficulty breathing. The mechanism of the antihypertensive effect of thiazides is not fully understood. The renin-aldosterone link is mediated by angiotensin II, so co-administration of an angiotensin II receptor antagonist tends to reverse the potassium loss associated with these diuretics.The major side effects include dizziness, nausea, swelling of the hands, ankles, or feet and sudden weight gain. Cresar H is a fixed-dose combination of Telmisartan, an orally active angiotensin II antagonist acting on the AT1 receptor subtype, and hydrochlorothiazide, a diuretic. If they continue for a prolonged period, consult your doctor. Its action is, therefore, independent of the pathways for angiotensin II synthesis. Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of angiotensin II on renin secretion, but the resulting increased plasma renin activity (PRA) and angiotensin II circulating levels do not overcome the effect of telmisartan on blood pressure. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium salt and chloride in approximately equivalent amounts.After oral administration of Cresar H, diuresis begins within 2 hours, peaks in about 4 hours and lasts about 6 to 12 hours. Telmisartan has much greater affinity (more than 3000-fold) for the AT1 receptor than for the AT2 receptor.Hydrochlorothiazide is a thiazide diuretic.Telmisartan does not inhibit the angiotensin converting enzyme ; hence, it does not affect the response to bradykinin.In normal volunteers, a dose of telmisartan 80 mg inhibited the pressor response to an intravenous infusion of angiotensin II by about 90% at peak plasma concentrations, with approximately 40% inhibition persisting for 24 hours. This combination provides synergistic reduction in blood pressure in hypertension patients. These side effects are minor and usually disappear within a week or two. Nevada, FL, OK, Denver, Missouri, El Paso, Brookhaven, Milwaukee, SD, Colorado, Michigan, Louisiana, Minnesota, Virginia, New Jersey, Georgia, Virginia, Houston, Fort Worth, Memphis, WI, Washington, Los Angeles, Georgia, Hempstead, Mississippi, Phoenix, Omaha, Massachusetts, Idaho, Nevada, WA, KY, New York, Indiana, Texas, Detroit, Montana, Washington, AL, Oklahoma City, District of Columbia, Nebraska, Mesa, Louisiana, DE, IL, Florida, Oregon, NM, MI, AZ, Austin, Rhode Island, Kentucky, KS, DC, Hawaii, San Francisco, Philadelphia, Las Vegas, Wisconsin, AK, Minnesota, VT, New Hampshire, MN, TN, Seattle, Pennsylvania, Colorado, Oakland, Kansas, MO, West Virginia, Alaska, Ohio, Ohio, Maine, Florida, Nashville-Davidson, NH, Oregon, TX, South Carolina, RI, OR, NJ, Tucson, IA, Michigan, Alabama, Indiana, Missouri, Minneapolis, Albuquerque, Indianapolis, NY, Tulsa, UT, OH, LA, Atlanta, CO, Miami, Wisconsin, ND, New Mexico, South Dakota, Long Beach, Cleveland, MT, Utah, California, Tennessee, Nebraska, Charlotte, Connecticut, Tennessee, San Diego, Oklahoma, Vermont, NE, Pennsylvania, Arizona, New York, HI, Kansas City, Massachusetts, North Carolina, Maryland, Chicago, GA, MS, MD, Texas, Delaware, Honolulu, ME, North Carolina, Dallas, AR, VA, WYIllinois, Iowa, ID, Baltimore, Arkansas, Washington, San Antonio, Illinois, WV, Fresno, Jacksonville, SC, North Dakota, MA, Columbus, Virginia Beach, NC, CT, San Jose, Portland, New Mexico, Colorado Springs. Arizona, Sacramento, California, NY, Oklahoma, PA, NV, Maryland, Boston, New Orleans, Hawaii, District of Columbia, Wyoming, CA, IN,