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It is a first-in-class drug candidate that promotes the following: Endothelial (blood vessels) cell differentiation, angiogenesis (growth of new blood cells from pre-existing vessels) in dermal tissues, keratinocyte migration, collagen deposition; and decreases inflammation.An additional key factor of TB 500 is that it promotes cell migration through a specific interaction with actin in the cell cytoskeleton. This peptide is present in wound fluid and when administered subcutaneously, it promotes wound healing, muscle building and speeds up recovery time of muscles fibres and their cells.One of TB 500 key mechanisms of action is its ability to regulate the cell-building protein, Actin, a vital component of cell structure and movement. These characteristics are uncovered by accelerating the migration of endothelial cells and keratinocytes. It has been demonstrated that a central small amino acid long-actin binding domain has both blood cell reproduction and wound healing characteristics. It also does not bind to the extracellular matrix and has a very low molecular weight meaning it can travel relatively long distances through tissues. TB 500 is different from other repair factors, such as growth factors, in that it promotes endothelial and keratinocyte migration.Research confirms that TB 500 is a potent, naturally occurring wound repair factor with anti-inflammatory properties.TB500 was identified as a gene that was up-regulated four-to-six fold during early blood vessel formation and found to promote the growth of new blood cells from the existing vessels. TB 500 not only binds to actin, but also blocks actin polymerization and is the actin-sequestering molecule in eukaryotic cells.This potent peptide is a member of a ubiquitous family of 16 related molecules with a high conservation of sequence and localization in most tissues and circulating cells in the body. It also increases the production of extracellular matrix-degrading enzymes. Of the thousands of proteins present in cells, actin represents up to 10% of the total proteins which therefore plays a major role in the genetic makeup of the cell. TB 500 is a synthetic version of the naturally occurring peptide present in virtually all human and animal cells, Thymosin Beta 4 (TB 500). Virginia, Colorado, Los Angeles, North Carolina, NE, Dallas, WA, Baltimore, OH, New Mexico, Tulsa, Charlotte, San Jose, OK, Michigan, TN, Maryland, Texas, NY, California, Oregon, New York, Washington, Las Vegas, Memphis, CA, Pennsylvania, LA, PA, VA, New York, Colorado Springs. Arizona, Hawaii, Idaho, San Francisco, AZ, Colorado, Milwaukee, Virginia Beach, Tucson, Seattle, Columbus, Omaha, Nebraska, Oregon, Cleveland, Illinois, HI, Kentucky, Delaware, IN, Indiana, CO, Brookhaven, Albuquerque, Maine, Jacksonville, South Carolina, Montana, Georgia, Sacramento, Minnesota, Minneapolis, SD, NM, Wyoming, GA, CT, New Jersey, Kansas City, MD, IA, Mississippi, Miami, Portland, NJ, Kansas, Austin, NC, Utah, Mesa, New Mexico, San Antonio, Wisconsin, Alabama, Nebraska, Ohio, AL, Arkansas, Connecticut, Alaska, Arizona, Tennessee, Wisconsin, WV, Oklahoma, Rhode Island, Michigan, Illinois, Oklahoma, Minnesota, North Dakota, NV, Ohio, South Dakota, WYIowa, Fresno, Houston, North Carolina, Phoenix, Washington, Hempstead, NY, Detroit, SC, District of Columbia, RI, DC, Indianapolis, Atlanta, Nashville-Davidson, San Diego, Nevada, NH, Honolulu, Oakland, MS, Maryland, Texas, VT, Louisiana, KS, DE, Florida, Florida, Louisiana, MI, IL, California, El Paso, Massachusetts, AR, Philadelphia, Georgia, ID, Pennsylvania, MN, Virginia, Washington, Missouri, WI, Tennessee, Indiana, Long Beach, ME, ND, District of Columbia, MO, MT, TX, UT, West Virginia, KY, Massachusetts, Nevada, New Orleans, FL, Missouri, MA, Denver, AK, Boston, Chicago, Vermont, New Hampshire, OR, Fort Worth, Hawaii, Oklahoma City,