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As with all insulin preparations, the time course of Apidra Solostar action may vary by individual or at different times in the same individual and is dependent on many conditions, including the site of injection, local blood supply, or local temperature.A reduction in the Apidra Solostar dose may be required in patients with renal or hepatic impairment.Insulin pens, needles, or syringes must never be shared between patients.Other adverse reactions commonly associated with Apidra Solostar include injection site reactions, lipodystrophy, pruritus, and rash. Observe for signs and symptoms of heart failure.Certain drugs may affect glucose metabolism, requiring insulin dose adjustment and close monitoring of blood glucose.Hypoglycemia is the most common adverse reaction of insulin therapy, including Apidra Solostar, which may be serious. Changes in insulin strength, manufacturer, type, or method of administration may result in the need for a change in insulin dose or an adjustment in concomitant oral antidiabetic treatment. Do not mix Apidra Solostar with any insulin when used in the pump or for intravenous administration.g.Fluid retention and heart failure can occur with concomitant use of thiazolidinediones (TZDs) with insulin. Do NOT reuse needles. Apidra Solostar is a rapid-acting insulin analog indicated to improve glycemic control in adults with type 2 diabetes or adults and children (4 years and older) with type 1 diabetes.Apidra Solostar for subcutaneous injection should not be mixed with insulins other than NPH. Consider dosage reduction or discontinuation of TZD if heart failure occurs. The signs of hypoglycemia may be reduced in patients taking anti-adrenergic drugs (e. Change insulin regimens cautiously and only under medical supervision., beta-blockers, clonidine, guanethidine, and reserpine).Apidra Solostar is contraindicated during episodes of hypoglycemia and in patients hypersensitive to Apidra Solostar or any of its excipients.When used as a mealtime insulin, the dose of Apidra Solostar should be given within 15 minutes before or within 20 minutes after starting a meal.Severe life-threatening, generalized allergy, including anaphylaxis, can occur. All insulins, including Apidra Solostar, can cause hypokalemia, which if untreated, may be serious. Apidra Solostar given by subcutaneous injection should normally be used in regimens that include a longer-acting insulin.Closely monitor blood glucose in all patients treated with insulin. VA, Alaska, California, Montana, Long Beach, AL, North Dakota, Florida, Atlanta, Pennsylvania, Tucson, New Jersey, Oregon, NC, District of Columbia, Portland, Honolulu, Virginia, Maryland, Columbus, Austin, South Dakota, DC, Boston, Sacramento, New York, New Orleans, NH, IL, Memphis, NE, Vermont, Minnesota, Illinois, MD, Indiana, NV, Arizona, CO, Colorado Springs. Arizona, San Francisco, LA, Texas, OK, Wyoming, Nevada, Texas, OH, MS, Idaho, Oklahoma, San Antonio, El Paso, Fresno, Utah, Dallas, UT, Minnesota, Delaware, Ohio, Miami, Phoenix, Missouri, Baltimore, Fort Worth, Minneapolis, San Jose, Ohio, Denver, MN, Alabama, ND, Arkansas, San Diego, WYAR, Wisconsin, Maryland, Las Vegas, AK, New Mexico, Nevada, Houston, West Virginia, Massachusetts, Michigan, NY, DE, KY, Iowa, Louisiana, Pennsylvania, TX, Charlotte, Los Angeles, Indianapolis, SD, North Carolina, Mississippi, MO, Maine, HI, ME, Chicago, Mesa, Hawaii, GA, Washington, Omaha, AZ, Milwaukee, Colorado, Oakland, Nashville-Davidson, Detroit, SC, New York, New Mexico, Washington, Virginia, Colorado, IN, Virginia Beach, FL, Seattle, Philadelphia, Tennessee, NY, Hempstead, WA, IA, Georgia, WV, CA, NM, Oklahoma, MI, Jacksonville, OR, Brookhaven, Kansas City, Nebraska, Missouri, Illinois, ID, Connecticut, Indiana, South Carolina, Cleveland, Hawaii, Albuquerque, Massachusetts, Florida, Wisconsin, Tennessee, Louisiana, KS, Michigan, WI, Nebraska, PA, CT, Tulsa, Georgia, VT, TN, District of Columbia, Rhode Island, Kentucky, North Carolina, Kansas, Washington, RI, MA, California, NJ, MT, Oregon, New Hampshire, Oklahoma City,