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Pragmatic trials are those that are designed to inform the real-world practice of clinical. They are usually focused on the practical aspects of study design, including the recruitment process and consent as well as adherence to the use of standard equipment.
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A pragmatic trial that uses a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is essential for pragmatic trials to be valid and to reduce bias in the results is also essential. However, too much heterogeneity can result in problems with the design of the trial.
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Pragmatic Play has gained a reputation for offering top-quality games and an outstanding user experience. Its software is accessible on mobile devices as well as in various languages. It has established itself as one of the top casino gaming platforms despite its relative youth. Wolves is one of the latest games which is a five-reel slot machine with a hefty RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.
Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. They are usually commissioned by policy makers and practitioners to aid in their decision-making. They can also be used to determine the causal relationship between an intervention and its results. However, they should not be used in lieu for explanatory studies.
The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory tests or if they should be an addition to them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which confirm the physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform policy and practice decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic research study which includes recruitment, design, implementation of the intervention, and follow-up.
There is a growing trend in the number of pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of these trials were conducted in primary care settings.