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Over more than 20 years hair analysis for drugs has been gaining increasing attention and recognition in various toxicological fields as preemployment and employment screening, forensic sciences, doping control of banned substances, clinical diagnostics in health problems. Hair analysis for drugs can expand the toxicological examination of conventional materials and thus contribute with additional important information to the complex evaluation of a certain case. Hair is a unique material for the retrospective investigation of chronic drug consumption, intentional or unintentional chronic poisoning in criminal cases, gestational drug exposure or environmental exposure to pollutants and adulterants and with specific ultrasensitive procedures allow to demonstrate even a previous single dose administration in a very low amount. Assuming the ideal hair steady and uniform growth, segmental hair analysis can provide the information about the time course of the substance use or exposure. However, the physiological background of hair growth, mechanisms of drug incorporation are not simple, not yet understood in full details and need not be evaluated exactly in all cases. The hair sampling, storage, sample preparation, analytical performance themselves are also very important for final results. Different laboratory attitudes can produce different results. The full information on circumstances of the case examined must be taken into account during interpretation. The pitfalls in hair analysis should be known and avoided to assure the responsible and correct interpretation of laboratory results adequate to an individual case. Biomedical papers , 2 , Open full article. Sachs H. Forensic Sci Int. Go to original source Go to PubMed J Nucl Med 20, Society of Hair Testing. Forensic Sci Int , Hair, sweat and saliva. UN, New York, Cassani M, Spiehler V. Forensic Sci Int 63, Spiehler V. Kintz P. Kintz P, editor. Drug Testing in Hair. Nakahara Y. Chromatogr B , Harkey MR. Alternative testing matrices. In: Karch SB, editor. Drug Abuse Handbook. Mangin P, Kintz P. Henderson GL. Forensic Sci Int 84, Einfluss der Pigmentierung auf den Ofloxacingehalt in Haaren bei Meerschweinchen. Rechtsmedizin 7, J Forensic Sci 42, Clin Chem 45, J Anal Toxicol 25, J Anal Toxicol 22, Int J Legal Med , J Anal Toxicol 20, Nakahara Y, Kikura R. Effect of structural factors on incorporation of drugs into hair: the incorporation rates of amphetamine analogs. Arch Toxicol 70, Effect of physicochemical properties on incorporation rates into hair. Biol Pharm Bull 18, Uhl M, Sachs H. J Anal Toxicol 19, - Cone EJ. An epidemiological study. Forensic Sci Int 89, Mieczkowski T. Forensic Med. Rivier L. J Pediatr , J Forensic Sci 38, Klein J. Identification of substances causing acute poisoning using hair root. Forensic Sci Int - in press Go to original source J Chromatogr B , J Forensic Sci 46, J Anal Toxicol 23, Application to forensic cases of drug facilitated crimes. Forensic Sci Int 70, Eur J Clin Pharmacol 58, Wennig R. Return to the content.

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