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A pill that could replace the need for diabetics to have insulin injections is in its final stage of clinical trials. Developed by Danish drug company Novo Nordisk , the once-daily pill known as oral semaglutide is part of a class of treatments known as GLP-1s. These drugs work by increasing the levels of hormones called incretins, which help the body produce more insulin only when needed. Find out more. Phase III trials to measure the efficacy and safety of oral semaglutide versus a placebo in subjects with type 2 diabetes are now ongoing. Results are expected this quarter. These trials follow a successful six-month Phase II study of patients which showed that the pill reduced blood sugar levels in those with type 2 diabetes as effectively as injected semaglutide. Up until now, GLP-1s have only been available as daily or weekly injections. The drug could potentially be launched in , making it the first oral GLP-1 available in pill form. Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge. We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form. The downsides of oral semaglutide are that patients must wait 30 minutes before eating after taking the pill, and that it can cause nausea. Another side effect observed in Phase II trials was that those who took oral semaglutide lost more weight than those who took the placebo pill. If successful, oral insulin has the potential to alter the way diabetes is managed. Other companies are developing similar drugs but Novo Nordisk is currently at the latest stage, with Oramed Pharmaceuticals expected to begin Phase II clinical trials for an oral diabetes drug in A strong pipeline could boost sales in an increasingly crowded insulin market. There are currently an estimated million diabetics globally, with numbers expected to rise to million by Give your business an edge with our leading industry insights. Thematic Take monthly. I consent to Verdict Media Limited collecting my details provided via this form in accordance with Privacy Policy. View all newsletters from across the GlobalData Media network. Go deeper with GlobalData. Data Insights The gold standard of business intelligence. How well do you really know your competitors? View profiles in store. Company Profile — free sample Thank you! Your download email will arrive shortly. Not ready to buy yet? Download a free sample We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form By GlobalData Submit. Tick here to opt out of curated industry news, reports, and event updates from Pharmaceutical Technology. Submit and download. Sign up for our daily news round-up! Sign up. Sign up to the newsletter: In Brief. I would also like to subscribe to:. Thank you for subscribing View all newsletters from across the GlobalData Media network.

UK could become 'smuggling hub' for herbal high khat

Olesund buying MDMA pills

Khat is mainly used by older men in the Somali community but there are fears its use is spreading. The UK could become a hub for smuggling the herbal stimulant khat, European police and politicians have warned. The Netherlands is the latest country to outlaw the sale of the plant, which is now banned in sixteen EU member states and Norway. Khat is freely sold in the UK and observers say the UK's isolated stance could make it the main base for Europe's khat trade. The British government has commissioned a new review of khat use. Until announcing its ban earlier this month, the Netherlands was similar in its stance to the UK where the East African plant is legally imported, sold and consumed. In the UK Home Office commissioned a report , external by the Advisory Council on the Misuse of Drugs ACMD which concluded that 'the evidence of harm resulting from khat use is not sufficient to recommend its control. In the UK, the drug is mainly consumed by people of Somali and Yemeni origin and the ACMD report concluded there was 'no evidence of its spread to the general population. Gerd Leers, Immigration and Integration Minister in the Netherlands, says he already has enough evidence of social harm caused by the drug to support a ban, which will come into force from June this year. Mark Lancaster, MP for Milton Keynes North, argued that khat should be outlawed in Britain , external in a speech he made in Parliament earlier this month. But others say that making khat a controlled drug could lead to further problems. Mr Klein argues that khat is chewed mainly by older men in the Somali diaspora and the practice will die out - rather like snuff has done in the UK. But British-Somali Muna Hassan is not so sure. She blames khat use for inducing her younger brother's paranoid schizophrenia. He has lived in the UK since the age of 5 and had a bright future ahead of him, studying at university, when he started chewing Khat. We know,' she says. Eleni Palazidou, a psychiatrist who has worked with the Somali community in east London, agrees. I think heavy, regular use is dangerous. I have no doubt that khat has a major adverse effect on people's mental health and does cause psychological problems,' she told The Report. The Netherlands' ban has been welcomed by Dutch citizens like Dagmar Oudshoorn, mayor of the village of Uithoorn, near Schipol, who says the khat trade has been a blight on her community. Neighbouring states, where the drug has long been illegal, have also put pressure on the Dutch government in The Hague because they have seen a sharp increase in khat trafficking from Holland. For Europe's Nordic countries, much of the khat arrives by truck across the Oresund bridge between Denmark and southern Sweden. They no longer want to be seen as a liberal country where tourists can come to smoke pot and buy drugs. Stefan Kalman, a senior detective in the Swedish drug squad, says customs officers catch smugglers on the border several times a week. They are also in a rush because the drug has to be consumed when it is fresh. Cathinone, one of the psychoactive agents in khat leaves, is highly unstable and loses its potency within three days of harvesting. With the door slammed shut in Holland, smugglers will turn to the UK despite the longer distances says Detective Kalman. Britain will become the new hub in Europe that is for certain. The British government has commissioned a new review of khat use , external - the date of its publication is still to be confirmed. Listen via the Radio 4 website or download the programme podcast. The Netherlands to ban khat use. Ethiopian farmers swap coffee for khat. Video Ethiopian farmers swap coffee for khat. Advisory Council on Misuse of Drugs. By Lucy Ash. More on this story. Around the BBC. BBC Radio 4. The Report. Related internet links. The Home Office.

Olesund buying MDMA pills