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1 déc. 2024 · Coronavirus disease 2019 (COVID-19) is a rapidly emerging public health crisis. Initially reported as a pneumonia of unknown origins in the Hubei Province of China, it is now known that this devastating disease is caused by the severe acute respiratory syndrome corona virus 2 or SARS-CoV-2. SARS-CoV-2 is a novel human β-coronavirus that shares high sequence homology with SARS-CoV. 1 déc. 2024 · Two of the primary features of Parkinson's disease (PD) are the accumulation of α-synuclein (α-Syn) and the depletion of lysosomal-associated membrane protein 1 (LAMP1) in the brain. Beneficial effects of environmental enrichment (EE) have been reported on the activation of lysosomal function and the amelioration of PD symptoms. Furthermore, Reelin could be a novel therapeutic target in PD.