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Findings could help address an unmet medical need and shed light on the molecular underpinnings of addiction. Researchers at University of California San Diego School of Medicine and the Salk Institute for Biological Studies have created a unique, cell-by-cell atlas of the amygdala, a small structure deep within the brain that plays a crucial role in controlling emotional responses to drugs. The findings, published October 5, in Nature Neuroscience , helped the researchers identify a potential new treatment for cocaine addiction, a disease that is poorly understood at the molecular level and has virtually no approved pharmacological treatments. Cocaine is a widely used illicit drug and addiction to cocaine is a major public health concern, associated with a rising number of overdose deaths and a high rate of relapse. Despite the threat cocaine addiction poses, not every person who uses cocaine develops an addiction. According to the National Institute on Drug Abuse , an estimated 4. The researchers studied brain samples from rats that had been allowed to self-administer cocaine for an extended period before being cut off from the drug for a period of abstinence. Jess Zhou, a UC San Diego graduate student working with McVicker, developed the bioinformatics workflow needed to assemble their sequencing data into a molecular atlas of the rat amygdala. The results revealed never-before-seen connections between addiction behaviors and genes involved in energy metabolism. In addition to identifying molecular factors that influence cocaine addiction behaviors, the researchers were able to test a drug in the rats that helped reverse these behaviors by targeting an enzyme involved in both energy metabolism and signaling between neurons. The researchers are now working on larger sample-size studies that can help determine how much of the effects they observed were based on preexisting genetics in the rats and how much were based on responses to extensive cocaine usage. Disclosures: Abraham A. Keep up with all the latest from UC San Diego. Subscribe to the newsletter today. Signup to get the latest UC San Diego newsletters delivered to your inbox. Award-winning publication highlighting the distinction, prestige and global impact of UC San Diego. Cellular Atlas of Amygdala Reveals New Treatment Target for Cocaine Addiction Findings could help address an unmet medical need and shed light on the molecular underpinnings of addiction. Story by: Miles Martin - milesmartin ucsd. Published Date October 05, Article Content Researchers at University of California San Diego School of Medicine and the Salk Institute for Biological Studies have created a unique, cell-by-cell atlas of the amygdala, a small structure deep within the brain that plays a crucial role in controlling emotional responses to drugs. Unraveling these genetics will be key to improving personalized medicine for addictions. Topics covered: cocaine addiction neurons neuroscience brain amygdala Share This:. You May Also Like. Subscription Notification Close Confirmation. Thank you!

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