Mut Akt

Mut Akt
Ipatasertib is an inhibitor of the AKT kinase, but its antitumor activity as monotherapy in patients with AKT mut tumors is unknown. We present efficacy and safety data of ipatasertib in patients with advanced/metastatic AKT mut solid tumors from Cohort E of the TAPISTRY trial (NCT04589845).
22 мая 2025 г.
14 июн. 2024 г.
How different oncogenic Akt mutants can affect the response to Akt inhibitors is currently unclear. Here, the authors analyse somatic mutations of Akt1-3 isoforms in several human cancers ...
The mechanism involved in mut-p53-induced activation of canonical Wnt appears to be via AKT-mediated phosphorylation of Ser 552 of β-catenin, which is known to stabilize and enhance its transcriptional activity.
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NOTCH1 mut and TP53 mut CLL samples had significantly increased AKT activation compared with wild type, whereas no such increase was observed in SF3B1 mut and ATM mut cases. Because both NOTCH1 and TP53 have been associated with transformation to RT, we hypothesized that increased AKT activity could be a common mechanism of transformation.
1 авг. 2024 г.
Plasmid MSCV Akt K179A mut from Dr. Scott Lowe's lab contains the insert Akt. This plasmid is available through Addgene.
Viele Menschen glauben,dass Veränderung Mut braucht.Dass man erst stark sein muss.Entschlossen.Bereit, alles hinter sich zu lassen.Doch hier auf Bali habe ic...
The pRetro-FLAG-MAZ (HA-myr-Akt, HA-mut-Akt, HA-K721R-EGFR, or HA-L858R-EGFR) plasmid was co-transfected with the pRetro-tet-on plasmid into MCF10A cells and then selected with 500 µg/ml G418 and 1 µg/ml puromycin. The resistant clones were picked out and expanded to mass culture.
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The mechanism involved in mut-p53-induced activation of canonical Wnt appears to be via AKT-mediated phosphorylation of Ser 552 of β-catenin, which is known to stabilize and enhance its transcriptional activity.
The serine/threonine kinase AKT is a key component of the PI3K/AKT/mTOR signaling pathway as it exerts a pivotal role in cell growth, proliferation, survival, and metabolism. Deregulation of this pathway is a common event in breast cancer including ...
In this work, we investigated the role of mut-p53 expressed by colon cancer cell lines in the canonical Wnt pathway. We show that mut-p53 increases β-catenin-dependent transcriptional activity through the PI3K/AKT axis. Moreover, our findings suggest that the mut-p53 GOF participates in the induction of chemoresistance to 5-FU in colon cancer ...
Reduction of forkhead box O1 (FOXO1) with increased phosphorylation of upstream serine/threonine kinase (AKT) was detected under HBx Mut overexpression. Thus, it is proposed that HBx Mut enhances disease progression by reducing FOXO1 via phosphorylation of AKT.
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Combination therapy of a HER2 inhibitor and an AKT inhibitor, as well as other PI3K pathway inhibitors, could overcome the therapeutic limitations associated with single-agent anti-HER2 treatment ...
Matching degrees were: supermatched (mut in PAM treated with a specific selective inh, such as PIK3CA mut - PI3Kα inh), matched (mut in PAM treated with a non-selective inh, such as PIK3CA mut - AKT inh) and unmatched (PAM inh without PAM mut). ClinBen was defined as partial response or stable disease for > 4 months (m).
In der heutigen Welt wird Zivilcourage immer wichtiger. Diese Einstellung ist eine Kombination aus Mut und Moral, die uns dazu verpflichtet,
In this work, we investigated the role of mut-p53 expressed by colon cancer cell lines in the canonical Wnt pathway. We show that mut-p53 increases β-catenin-dependent transcriptional activity through the PI3K/AKT axis. Moreover, our findings suggest that the mut-p53 GOF participates in the induction of chemoresistance to 5-FU in colon cancer ...
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9 июл. 2024 г.
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Gastrointestinal (GI) cancer is the second most common cancer type with mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) phenotype that is expected to respond to immune-checkpoint inhibitors (ICIs). However, approximately ...
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Moreover, the PI3K-AKT signaling pathway has been shown to positively correlate with PDGFRα expression in multiple cancers. Augmented PDGFRα was associated with poor survival of cancer patients.
24 июл. 2025 г.
The main purpose of this review is to present general aspects of breast cancer, the components of the AKT signaling pathway, the factors that activate this protein kinase B, PI3K/AKT-breast cancer mutations, PI3K/AKT/mTOR-inhibitors, and the relationship between everolimus, temsirolimus and endocrine therapy.
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528Background: PAMi are being developed in unselected populations with MBC, but not all pts derive equal benefit. Aim: to assess predictive factors influencing PAMi efficacy in MBC pts enrolled in phaseI/II clinical trials, with exploratory analysis ...
In addition, the phosphatidylinositol 3-kinase (PI3K)/Ak strain transforming (AKT) pathway is frequently altered and represents a promising therapeutic target for BC. Understanding the combined prognostic impact of TP53 mut and PI3K/AKT pathway alterations across BC subtypes remains underexplored.
Background A significant subset of mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) gastric adenocarcinomas (GAC) are resistant to immune checkpoint inhibitors (ICIs), yet the underlying mechanism remains largely unknown. We sought to investigate the genomic correlates of the density of tumor-infiltrating immune cells (DTICs) and primary resistance to ICI treatment ...
5 июн. 2024 г.
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PIK3CA mutations occur in approximately 40% of patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer. The PI3Kα-specific ...
20 мар. 2024 г.
1 янв. 2025 г.
In this work, we investigated the role of mut-p53 expressed by colon cancer cell lines in the canonical Wnt pathway. We show that mut-p53 increases β-catenin-dependent transcriptional activity through the PI3K/AKT axis. Moreover, our findings suggest that the mut-p53 GOF participates in the induction of chemoresistance to 5-FU in colon cancer ...
A.md Akt · i am a fresh graduate from Accounting Assosiate Degree of Politeknik Harapan Bersama Tegal able to learn new things, hard worked, talk too much. english | passive · Pengalaman: PT PETROMITRA PACIFIC INTERNUSA( PETROASIA LUBRICANTS) · Pendidikan: Politeknik Harapan Bersama Tegal · Lokasi: Kota Tegal · 1 koneksi di LinkedIn. Lihat profil Mut Mainah di LinkedIn, komunitas ...
Abstract. S100A7 is among the most highly expressed genes in preinvasive breast cancer, is a marker of poor survival when expressed in invasive disease, and promotes breast tumor progression in experimental models. To explore the mechanism of action, we examined the role of S100A7 in cell survival and found that overexpression of S100A7 in MDA-MB-231 cell lines promotes survival under ...
The transmembrane and coiled‐coil domains 3 (TMCO3) are highly expressed in many tumors. However, the underlying mechanisms governing the way in which TMCO3 affects the progression of hepatocellular carcinoma (HCC) remain unclear. This study screens ...
26 апр. 2025 г.
The AKT1 gene provides instructions for making a protein called AKT1 kinase. Learn about this gene and related health conditions.
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The mechanism involved in mut-p53-induced activation of canonical Wnt appears to be via AKT-mediated phosphorylation of Ser 552 of β-catenin, which is known to stabilize and enhance its transcriptional activity.
13 апр. 2025 г.
AKT pathway activation is implicated in endocrine-therapy resistance. Data on the efficacy and safety of the AKT inhibitor capivasertib, as an addition to fulvestrant therapy, in patients with horm...
The anti-tumor activity was associated with suppression of p-AKT and a mechanism of blocking nuclear factor-κB activation driven by CD79mut, CARD11 mut, TNFAIP3 mut, or MYD88 mut. Inhibition of PI3Kα/δ resulted in tumor regression in an ibrutinib-resistant CD79BWT /MYD88 mut patient-derived ABC-DLBCL model.
22 июл. 2024 г.
Flight from RAF Akrotiri (AKT) to Muscatine Municipal Airport (MUT)
9 окт. 2024 г.
Here we provide a preliminary insight into the influence of MTH1 levels on the EMT phenotype and Akt activation in RAS-transformed HMLE breast epithelial cells.
The anti-tumor activity was associated with suppression of p-AKT and a mechanism of blocking nuclear factor-κB activation driven by CD79 mut, CARD11 mut, TNFAIP3 mut, or MYD88 mut. Inhibition of PI3Kα/δ resulted in tumor regression in an ibrutinib-resistant CD79B WT /MYD88 mut patient-derived ABC-DLBCL model.
13 дек. 2024 г.
Results will indicate the role of MAP3K8 WT and MUT over expression on the phosphorylation events of proteins involved in the AKT and PKC pathway.
An actors framework for Rust and Tokio. An actors framework for Rust and Tokio. It is heavily inspired by Actix and right now it has very similar look and feel. The main difference is that in Actix (at least at the moment of this particular library creation) working with async / await and async handlers in particular is a little cumbersome. This library supports async handlers out of the box ...
Phosphorylation of TWIST1 by AKT promotes EMT and metastasis via TGF-β2 transcriptional regulation and PI3K/AKT feedback activation.
25 мар. 2024 г.
Luminal 雄激素受体 (LAR) 亚型富含潜在的可靶向生物标志物，包括高雄激素受体 (AR) 表达、高 PIK3CA 突变率和完整的 Rb。 本研究的目的是探讨 LAR TNBC 临床前模型中 CDK4/6、AR 和 PI3K-AKT 抑制剂最有效的组合，以供未来的临床试验设计。
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Results SMAD4 mut CRC cell lines undergo EMT-associated morphological changes in the presence of SNAIL1
17 апр. 2024 г.
Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating several cell functions of cancer cells. Several natural products modulate both oxidative stress and AKT for anticancer effects. However, the impact of natural product-modulating oxidative stress and AKT on cell functions lacks systemic understanding. Notably, the contribution of regulating cell functions by ...
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