Mr Dominant Casein

Mr Dominant Casein

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BMC Cancer

v.16; 2016

PMC4973074

Published online 2016 Aug 3. doi: 10.1186/s12885-016-2643-0
Department of Dermatology, Division of Dermatooncology, Eberhard-Karls-University Tübingen, Liebermeisterstr 25, D-72076 Tübingen, Germany
Received 2015 Oct 4; Accepted 2016 Jun 15.

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/ ) applies to the data made available in this article, unless otherwise stated.
Keywords: CK1, Melanoma, Beta-catenin, p53
1. Miller AJ, Mihm MC., Jr Melanoma. N Engl J Med. 2006; 355 :51–65. doi: 10.1056/NEJMra052166. [ PubMed ] [ CrossRef ] [ Google Scholar ]
2. Damsky WE, Curley DP, Santhanakrishnan M, Rosenbaum LE, Platt JT, Gould Rothberg BE, Taketo MM, Dankort D, Rimm DL, McMahon M, Bosenberg M. β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Cancer Cell. 2011; 20 :741–54. doi: 10.1016/j.ccr.2011.10.030. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ]
3. Knippschild U, Krüger M, Richter J, Xu P, García-Reyes B, Peifer C, Halekotte J, Bakulev V, Bischof J. The CK1 family: contribution to cellular stress response and its role in carcinogenesis. Front Oncol. 2014; 4 :96. doi: 10.3389/fonc.2014.00096. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ]
4. Schittek B, Sinnberg T. Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis. Mol Cancer. 2014; 13 :231. doi: 10.1186/1476-4598-13-231. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ]
5. Del Valle-Pérez B, Arqués O, Vinyoles M, de Herreros AG, Duñach M. Coordinated action of CK1 isoforms in canonical Wnt signaling. Mol Cell Biol. 2011; 31 :2877–88. doi: 10.1128/MCB.01466-10. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ]
6. Cruciat C-M. Casein kinase 1 and Wnt/β-catenin signaling. Curr Opin Cell Biol. 2014; 31 :46–55. doi: 10.1016/j.ceb.2014.08.003. [ PubMed ] [ CrossRef ] [ Google Scholar ]
7. Bernatik O, Ganji RS, Dijksterhuis JP, Konik P, Cervenka I, Polonio T, Krejci P, Schulte G, Bryja V. Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases. J Biol Chem. 2011; 286 :10396–410. doi: 10.1074/jbc.M110.169870. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ]
8. Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell. 2002; 108 :837–47. doi: 10.1016/S0092-8674(02)00685-2. [ PubMed ] [ CrossRef ] [ Google Scholar ]
9. Sinnberg T, Menzel M, Kaesler S, Biedermann T, Sauer B, Nahnsen S, Schwarz M, Garbe C, Schittek B. Suppression of casein kinase 1alpha in melanoma cells induces a switch in beta-catenin signaling to promote metastasis. Cancer Res. 2010; 70 :6999–7009. doi: 10.1158/0008-5472.CAN-10-0645. [ PubMed ] [ CrossRef ] [ Google Scholar ]
10. Venerando A, Marin O, Cozza G, Bustos VH, Sarno S, Pinna LA. Isoform specific phosphorylation of p53 by protein kinase CK1. Cell Mol Life Sci. 2010; 67 :1105–18. doi: 10.1007/s00018-009-0236-7. [ PubMed ] [ CrossRef ] [ Google Scholar ]
11. Huart A-S, MacLaine NJ, Meek DW, Hupp TR. CK1alpha plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability. J Biol Chem. 2009; 284 :32384–94. doi: 10.1074/jbc.M109.052647. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ]
12. Eberle J, Spangler B, Becker JC, Heinemann SH, Klein CA, Kunz M, Kuphal S, Langer P, Mauch C, Meierjohann S, Paschen A, Schadendorf D, Schartl M, Schittek B, Schönherr R, Tüting T, Zigrino P, Bosserhoff AK. Multicentre study on standardisation of melanoma cell culture--an initiative of the German Melanoma Research Network. Pigment Cell Melanoma Res. 2010; 23 :296–8. doi: 10.1111/j.1755-148X.2010.00684.x. [ PubMed ] [ CrossRef ] [ Google Scholar ]
13. Meier F, Nesbit M, Hsu MY, Martin B, Van Belle P, Elder DE, Schaumburg-Lever G, Garbe C, Walz TM, Donatien P, Crombleholme TM, Herlyn M. Human melanoma progression in skin reconstructs: biological significance of bFGF. Am J Pathol. 2000; 156 :193–200. doi: 10.1016/S0002-9440(10)64719-0. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ]
14. Sinnberg T, Lasithiotakis K, Niessner H, Schittek B, Flaherty KT, Kulms D, Maczey E, Campos M, Gogel J, Garbe C, Meier F. Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide. J Invest Dermatol. 2009; 129 :1500–15. doi: 10.1038/jid.2008.379. [ PubMed ] [ CrossRef ] [ Google Scholar ]
15. Lasithiotakis KG, Sinnberg TW, Schittek B, Flaherty KT, Kulms D, Maczey E, Garbe C, Meier FE. Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells. J Invest Dermatol. 2008; 128 :2013–23. doi: 10.1038/jid.2008.44. [ PubMed ] [ CrossRef ] [ Google Scholar ]
16. Sinnberg T, Menzel M, Ewerth D, Sauer B, Schwarz M, Schaller M, Garbe C, Schittek B. β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance. PLoS One. 2011; 6 :e23429. doi: 10.1371/journal.pone.0023429. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ]
17. Krochmann J, Sinnberg T, Meier F, Garbe C, Busch C. Melanoma cells in distinct growth phases retain specific invasive qualities during brain metastasis in vivo. Pigment Cell Melanoma Res. 2012; 25 :113–4. doi: 10.1111/j.1755-148X.2011.00914.x. [ PubMed ] [ CrossRef ] [ Google Scholar ]
18. Meier F, Busch S, Gast D, Göppert A, Altevogt P, Maczey E, Riedle S, Garbe C, Schittek B. The adhesion molecule L1 (CD171) promotes melanoma progression. Int J Cancer. 2006; 119 :549–55. doi: 10.1002/ijc.21880. [ PubMed ] [ CrossRef ] [ Google Scholar ]
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21. Knippschild U, Milne DM, Campbell LE, DeMaggio AJ, Christenson E, Hoekstra MF, Meek DW. p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs. Oncogene. 1997; 15 :1727–36. doi: 10.1038/sj.onc.1201541. [ PubMed ] [ CrossRef ] [ Google Scholar ]
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27. Behrend L, Stöter M, Kurth M, Rutter G, Heukeshoven J, Deppert W, Knippschild U. Interaction of casein kinase 1 delta (CK1delta) with post-Golgi structures, microtubules and the spindle apparatus. Eur J Cell Biol. 2000; 79 :240–51. doi: 10.1078/S0171-9335(04)70027-8. [ PubMed ] [ CrossRef ] [ Google Scholar ]
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41. Winter M, Milne D, Dias S, Kulikov R, Knippschild U, Blattner C, Meek D. Protein kinase CK1delta phosphorylates key sites in the acidic domain of murine double-minute clone 2 protein (MDM2) that regulate p53 turnover. Biochemistry. 2004; 43 :16356–64. doi: 10.1021/bi0489255. [ PubMed ] [ CrossRef ] [ Google Scholar ]
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Articles from BMC Cancer are provided here courtesy of BioMed Central
1. Miller AJ, Mihm MC., Jr Melanoma. N Engl J Med. 2006; 355 :51–65. doi: 10.1056/NEJMra052166. [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
2. Damsky WE, Curley DP, Santhanakrishnan M, Rosenbaum LE, Platt JT, Gould Rothberg BE, Taketo MM, Dankort D, Rimm DL, McMahon M, Bosenberg M. β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Cancer Cell. 2011; 20 :741–54. doi: 10.1016/j.ccr.2011.10.030. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
3. Knippschild U, Krüger M, Richter J, Xu P, García-Reyes B, Peifer C, Halekotte J, Bakulev V, Bischof J. The CK1 family: contribution to cellular stress response and its role in carcinogenesis. Front Oncol. 2014; 4 :96. doi: 10.3389/fonc.2014.00096. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
4. Schittek B, Sinnberg T. Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis. Mol Cancer. 2014; 13 :231. doi: 10.1186/1476-4598-13-231. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
5. Del Valle-Pérez B, Arqués O, Vinyoles M, de Herreros AG, Duñach M. Coordinated action of CK1 isoforms in canonical Wnt signaling. Mol Cell Biol. 2011; 31 :2877–88. doi: 10.1128/MCB.01466-10. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
6. Cruciat C-M. Casein kinase 1 and Wnt/β-catenin signaling. Curr Opin Cell Biol. 2014; 31 :46–55. doi: 10.1016/j.ceb.2014.08.003. [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
7. Bernatik O, Ganji RS, Dijksterhuis JP, Konik P, Cervenka I, Polonio T, Krejci P, Schulte G, Bryja V. Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases. J Biol Chem. 2011; 286 :10396–410. doi: 10.1074/jbc.M110.169870. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
8. Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell. 2002; 108 :837–47. doi: 10.1016/S0092-8674(02)00685-2. [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
9. Sinnberg T, Menzel M, Kaesler S, Biedermann T, Sauer B, Nahnsen S, Schwarz M, Garbe C, Schittek B. Suppression of casein kinase 1alpha in melanoma cells induces a switch in beta-catenin signaling to promote metastasis. Cancer Res. 2010; 70 :6999–7009. doi: 10.1158/0008-5472.CAN-10-0645. [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
10. Venerando A, Marin O, Cozza G, Bustos VH, Sarno S, Pinna LA. Isoform specific phosphorylation of p53 by protein kinase CK1. Cell Mol Life Sci. 2010; 67 :1105–18. doi: 10.1007/s00018-009-0236-7. [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
11. Huart A-S, MacLaine NJ, Meek DW, Hupp TR. CK1alpha plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability. J Biol Chem. 2009; 284 :32384–94. doi: 10.1074/jbc.M109.052647. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
12. Eberle J, Spangler B, Becker JC, Heinemann SH, Klein CA, Kunz M, Kuphal S, Langer P, Mauch C, Meierjohann S, Paschen A, Schadendorf D, Schartl M, Schittek B, Schönherr R, Tüting T, Zigrino P, Bosserhoff AK. Multicentre study on standardisation of melanoma cell culture--an initiative of the German Melanoma Research Network. Pigment Cell Melanoma Res. 2010; 23 :296–8. doi: 10.1111/j.1755-148X.2010.00684.x. [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
13. Meier F, Nesbit M, Hsu MY, Martin B, Van Belle P, Elder DE, Schaumburg-Lever G, Garbe C, Walz TM, Donatien P, Crombleholme TM, Herlyn M. Human melanoma progression in skin reconstructs: biological significance of bFGF. Am J Pathol. 2000; 156 :193–200. doi: 10.1016/S0002-9440(10)64719-0. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
15. Lasithiotakis KG, Sinnberg TW, Schittek B, Flaherty KT, Kulms D, Maczey E, Garbe C, Meier FE. Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells. J Invest Dermatol. 2008; 128 :2013–23. doi: 10.1038/jid.2008.44. [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
16. Sinnberg T, Menzel M, Ewerth D, Sauer B, Schwarz M, Schaller M, Garbe C, Schittek B. β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance. PLoS One. 2011; 6 :e23429. doi: 10.1371/journal.pone.0023429. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
17. Krochmann J, Sinnberg T, Meier F, Garbe C, Busch C. Melanoma cells in distinct growth phases retain specific invasive qualities during brain metastasis in vivo. Pigment Cell Melanoma Res. 2012; 25 :113–4. doi: 10.1111/j.1755-148X.2011.00914.x. [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
18. Meier F, Busch S, Gast D, Göppert A, Altevogt P, Maczey E, Riedle S, Garbe C
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