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These datasets underpin the analysis presented in the agency's work. Most data may be viewed interactively on screen and downloaded in Excel format. All countries. Topics A-Z. The content in this section is aimed at anyone involved in planning, implementing or making decisions about health and social responses. Best practice. We have developed a systemic approach that brings together the human networks, processes and scientific tools necessary for collecting, analysing and reporting on the many aspects of the European drugs phenomenon. Explore our wide range of publications, videos and infographics on the drugs problem and how Europe is responding to it. All publications. More events. More news. We are your source of drug-related expertise in Europe. We prepare and share independent, scientifically validated knowledge, alerts and recommendations. About the EUDA. Key findings and threat assessment. Global context. Overview of production. Distribution and supply. Actions to address current threats and increase preparedness. Synthetic cathinones first appeared on the European fdrug market in Since then, they have been sold as replacements for controlled stimulants such as amphetamines, cocaine and MDMA. They are also mis-sold as these controlled stimulants to unsuspecting consumers. Typically, they are found as powders and, to a lesser degree, tablets. In the latter case, these may be mis-sold as or used to adulterate MDMA ecstasy tablets. Other physical forms are reported to a much smaller degree. The cathinones are used recreationally, but they are also used by high-risk drug users in some countries, including by people who inject stimulants and opioids. This also includes in the context of chemsex. In some cases, changes in patterns of use, such as an increase in injecting frequency with cathinones, have been linked to HIV and HCV outbreaks. There are some indications that certain cathinones, such as 4-MMC mephedrone , 4-CMC clephedrone and 3-CMC clophedrone , may be becoming more established in Europe, in part due to domestic production that takes place mainly in the Netherlands and Poland. Until around , most bulk quantities of synthetic cathinones seized at the external EU borders originated in China. However, since then, production has also spread to India, where these substances are apparently produced on a large scale. In addition, the production of synthetic cathinones continues to grow in parts of Europe. At least 68 illicit laboratories dismantled in Europe since were producing cathinones. Preliminary information from the Polish Police suggests that the production of cathinones in Poland has continued to be significant in and , with 17 laboratories dismantled in and 16 in the first six months of In the Netherlands, four laboratories were seized in and at least two in , all of which were manufacturing 4-CMC, 3-CMC or both. It was reported that Polish individuals were alleged to have been involved in the laboratories found in the Netherlands. In the smaller sites, production appears to be destined mostly for local markets and, occasionally, for sale on the darknet. Although information is very limited, larger production sites also appear to supply local markets and occasionally the finished product is exported outside Europe see Box Dismantled 4-MMC laboratory in Austria, Cathinone production does not require sophisticated equipment. Nonetheless, production appears to be getting more industrialised and efficient. In Poland, basic laboratory glassware has been gradually replaced by large plastic reactors with cooling, heating and mixing systems and temperature control. This demonstrates some interest in improving production efficiency, since heating or mixing are not required to synthesise most cathinones, but their use increases reaction speed and yields. In several dismantled laboratories, the producers alternated between the production of different cathinones e. The production of synthetic cathinones is a relatively straightforward process. Step 1 — preparation of 2-bromomethylpropiophenone; step 2 — preparation of 4-MMC by amination with methylamine. The bromine required for this step can be commercially obtained as a liquid or prepared in the clandestine facility. This is by far the most challenging and hazardous step of the process, given the high toxicity and corrosive properties of bromine. This amine can be changed according to the desired product. For example, methylamine is the compound of choice for the production of mephedrone or clephedrone. Methylamine is also commonly used in the production of methamphetamine and MDMA. The amination step does not require heating and can be easily scaled up, making it a relatively simple procedure to execute. This synthesis produces the desired products as racemic mixtures. Finally, the resulting base products are converted into salts typically hydrochloride salts and then recrystallised to remove impurities in the large plastic trays that are characteristic findings in cathinone production facilities see Photos Dismantled site associated with 4-CMC production in Poland, seized in with approximately 2 litres of 4-CMC seized Wojciech, The preparation of cathinones using this method is an industrially efficient process for two reasons. First, because bromopropiophenones are commercially available in several variations and are not subject to any international regulatory controls, the first step can be skipped altogether. And also because the bromopropiophenones can be divided into batches and each batch used to produce a different cathinone, if desired Collins et al. Theoretically, 0. Both information from dismantled laboratories and precursor seizure data confirm that European producers mostly start the production of cathinones from the second amination step. From to , approximately 3. These seizures included 3. More than half of the precursors seized during this time were for the production of 4-MMC 2. Almost half of all seizures were reported by the Netherlands 1. Seizures were also reported by Belgium, France, Hungary and Austria. As these compounds are not under legal control, seizures tend to occur only when customs irregularities are detected such as misdeclaration or when law enforcement investigations occur. Additional seizures 0. Where the origin was known, cathinone precursor shipments originated in China and India. Seizures of cathinone precursors not occurring at the EU external borders often occurred in illicit cathinone laboratories, mainly in Poland and the Netherlands. Source: European database on drug precursors. Large seizures of cathinone precursors have taken place in China, Russia, Ukraine and Taiwan. Some seizures were associated with large cathinone laboratories in Russia and Ukraine. In China, the precursors were seized at a chemical production plant. Notwithstanding its global ranking, both precursor seizure data and data collected from dismantled production facilities show that cathinone production is a well-established feature of the European market, especially in Poland and to a lesser extent in the Netherlands, with precursors and material for the synthesis acquired and transported via neighbouring countries including Germany, France and Luxembourg. The dumping of hazardous chemical waste from these production sites may result in significant environmental damage, directly affecting the surrounding areas, and possibly affecting the population and the aquatic environment including surface and drinking water ter Laak and Emke, In addition to full synthesis in Europe, chemically masked derivatives of controlled synthetic cathinones can be produced to evade detection by law enforcement such as customs agencies. In this scheme, the cathinone is chemically masked to produce a non-controlled substance, which can be converted back into the parent cathinone drug. It is thought that this derivative was intended to be converted to 3-MMC, for example by acid hydrolysis using hydrochloric acid. Approximately kilograms of 3-MMC were also seized at the site. These masked drugs are not controlled and can be ordered and transported using the same channels as new psychoactive substances. After falling from a peak of 1. This increase was driven by a small number of large seizures by customs agencies in the Netherlands and Spain. All of these consignments originated from India see Table Reported large seizures of cathinones originating from India in Of this material, The number of synthetic cathinone seizures and the quantity seized varies across Europe, with the highest number of seizures carried out by police in Poland and the greatest quantities seized by customs in the Netherlands see Figure Seizures of synthetic cathinones reported to the EU Early Warning System by country: numbers of seizures and quantity of material seized for all forms reported in weight, European Union, Information on the price and purity of cathinones is not collected systematically in Europe. The wholesale and street prices for tablets containing these cathinones are not available. Cathinones were also detected in tablets seizures totalling to 50 units and seizures totalling to 7. While the overall scale of this issue is unknown, it has been reported by drug checking services in at least three EU Member States, namely Spain, the Netherlands and Austria. All of the source data used in graphics and data tables may be found in our Data catalogue. Consult the list of references used in this module. Homepage Quick links Quick links. GO Results hosted on duckduckgo. Main navigation Data Open related submenu Data. Latest data Prevalence of drug use Drug-induced deaths Infectious diseases Problem drug use Treatment demand Seizures of drugs Price, purity and potency. Drug use and prison Drug law offences Health and social responses Drug checking Hospital emergencies data Syringe residues data Wastewater analysis Data catalogue. Selected topics Alternatives to coercive sanctions Cannabis Cannabis policy Cocaine Darknet markets Drug checking Drug consumption facilities Drug markets Drug-related deaths Drug-related infectious diseases. Recently published Findings from a scoping literature…. Penalties at a glance. Frequently asked questions FAQ : drug…. FAQ: therapeutic use of psychedelic…. Viral hepatitis elimination barometer…. EU Drug Market: New psychoactive…. EU Drug Market: Drivers and facilitators. Statistical Bulletin home. Quick links Search news Subscribe newsletter for recent news Subscribe to news releases. This make take up to a minute. Once the PDF is ready it will appear in this tab. Sorry, the download of the PDF failed. Table of contents Search within the book. Introduction Introduction Key findings and threat assessment Key findings and threat assessment Global context Global context Overview of production Overview of production Distribution and supply Distribution and supply Actions to address current threats and increase preparedness Actions to address current threats and increase preparedness. Search within the book Operator Any match. Exact term match only. Top five synthetic cathinones seized by number of seizures reported to the EU Early Warning System, European Union, 9 seizures. Top five synthetic cathinones seized by quantity of material seized for all forms reported in weight reported to the EU Early Warning System, European Union, Seizures of synthetic cathinones reported to the EU Early Warning System by country: quantity of material seized for all forms reported in weight, European Union, Main subject. Target audience. Publication type. New psychoactive substances — Distribution and supply in Europe. On this page.
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Impact of the Ukraine war on drug markets in South Eastern Europe. The Western Balkans is a crossroads for the trafficking of many illicit commodities, and it is a geographical hub for the smuggling of migrants who are trying to enter Western Europe. Anti-corruption conference focuses on enhancing prevention and dialogue. The Observatory aims to enable civil society to identify, analyze and map criminal trends, and their impact on illicit flows, governance, development, interethnic relations, security and the rule of law, and supports them in their monitoring of national dynamics and wider regional and international organized-crime trends. Explore by drug type Mean retail price. Open-source database Drugs prices in Montenegro. Latest analysis from the observatory. Disruption or displacement? Impact of the Ukraine war on drug markets in South Eastern Europe The Western Balkans is a crossroads for the trafficking of many illicit commodities, and it is a geographical hub for the smuggling of migrants who are trying to enter Western Europe. Read more. Featured contents. See more. The See Obs. Read More.
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