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Monrovia buying Heroin
In , psychiatrist Marie Nyswander was sitting in a storefront clinic in Harlem with a group of addicts. Some of them were there for help, but others had just come to sit and chat over a cup of coffee. Free heroin. And he turned it down. To reach this point in her career, Marie Nyswander had meandered along a convoluted, sometimes impulsive, path of personal and professional highways and byways. But collectively those paths led her, perhaps inevitably, to that Harlem narcotics clinic and to a discovery that has transformed the way we view and treat opiate addiction. Her parents divorced when she was two years old, and consequently, she was raised mainly by her mother, Dorothy Bird Nyswander. She then taught advanced statistics, psychology, and public health at various universities and was instrumental in founding the Berkeley School of Public Health. After retiring from academia, Dorothy spent 16 years with the World Health Organization, traveling widely. In India, she developed education programs on birth control and vaccination, as well as the curricula for new schools of public health. Dorothy was fearless and instilled in her daughter the same toughness, intellectual freedom, and devotion to serving others. She also included her daughter in discussions with her friends, anthropologist Margaret Mead and the Gestalt psychologist Max Wertheimer, among others. In , Marie contracted tuberculosis and spent a year at a sanatorium in Monrovia, Calif. While recuperating, she read widely and nurtured her already independent, progressive views. In , Dorothy moved to New York City to begin a four-year research project on school health services. For courses not in the curriculum, such as physical chemistry, they brought in teachers from other schools. Marie graduated in and applied to 20 medical schools. She was accepted to all of them. She chose Cornell University Medical College. Marie then sought a naval position, but the U. Navy did not take female surgeons. Public Health Service, hoping to travel and have an international adventure. The Lexington facility opened in as a federal drug rehabilitation hospital and prison. The sprawling hospital complex was surrounded by thousands of acres of farmland and old-growth trees. Legislation in had banned heroin for any purpose and instantly criminalized opiate addiction in the United States. Prisons soon filled up and by the late s, one-third of people in federal prisons were those with drug convictions. In response, the federal government established Lexington, a first-of-its-kind facility. About one-third of the addicts came voluntarily for detoxification, but everyone was called a patient, whether they were there voluntarily or not. New patients were required to stop using drugs. The medical staff would ease their withdrawal symptoms by tapering the dose of morphine over several weeks. Then, the patients joined the general population for the rest of their stay. There was some individual and group psychotherapy, but mostly, the recovering addicts were kept busy with craft classes, work and recreation. Lexington also housed a research clinic, which sought cures for drug addiction. Although informed consent regulations did not yet exist, all of the research subjects were strictly volunteers and were fully briefed on the experimental protocols. Nyswander arrived at Lexington for a medical residency and had no particular interest in addiction. Her assignments included surgery, withdrawal management, therapy, and parole evaluation. At 26, Nyswander was single and the only female doctor. They branded the addicts as psychopaths, ordered them about, and subjected them to racial slurs. Instead, she developed a rapport with the patients, many of whom treated her kindly. But the job could be scary. When the female patients rioted, the guards sent her to diffuse the situation. Trembling with fear, Nyswander bravely walked in, offered the women cigarettes, talked to them, and managed to calm them down, while the guards put out the fire. There were many things Nyswander disliked about Lexington, but her most enduring memories were the patients who looked out for her when she was feeling lonely. She wanted to learn more about these patients and the pathology of the addiction. When she was discharged from the Public Health Service in , she enrolled in a three-year comprehensive course in psychoanalysis at New York Medical College. In New York, the standard method for treating addiction was abrupt abstinence, a wrenching and often violent process. When she faced stern resistance to the Lexington method, a Bellevue colleague encouraged her to publish a paper on her views. The paper was a practical guide for doctors with only the resources available in the average hospital. In , Nyswander set up a private psychiatry practice on Park Avenue. She dealt with a full range of psychiatric problems. The medical literature on opiate addiction was sparce, and her paper marked her as an authority. She received a steady stream of inquiries. Nyswander wanted to help, but she had few tools at her disposal. She had been trained in Freudian psychoanalysis, and medical schools did not cover addiction. No one knew much about it, including Freud. In standard practice, addicted patients were hospitalized during withdrawal. But large metropolitan hospitals, including in New York, refused to admit them. Addicts would also force nurses to open narcotics cabinets. The first patient Nyswander supervised through a drug withdrawal was an elderly man who had become addicted to morphine following surgery. After that, Nyswander oversaw successful withdrawals of hundreds of home-based addicts. For addicts who wanted to kick their habit and who had a supportive relative or friend, Nyswander gave the caregivers instructions over the phone. In , New York State held a hearing about the addiction problem. Nyswander now an acknowledged expert testified about her experiences in Lexington. She was asked if there was a specific remedy to treat drug addiction. Do you think that psychiatry in and of itself is the answer to the treatment and cure of addicts? In , Nyswander organized her first clinical study. It was a pioneering study, demonstrating that some addicts could be withdrawn as outpatients, but obviously, psychotherapy helped very few of them. It summarized her experiences and views on addiction treatment. They ranged from a self-educated homicidal paranoid to a graduate student at MIT. She concluded that everyone had the potential for drug addiction, regardless of intelligence, social status, occupation, religion, or race. Some addicts would cycle between addiction and detoxification repeatedly. Nyswander was becoming frustrated. Her own heavy smoking may have led her to question whether addiction was a psychiatric disorder at all. She started smoking at 14 and by the s was smoking three packs a day. Once, she managed to quit for 8 months. She concluded that rehabilitation should not deprive addicts of the drugs that stabilized them. In the s and s, organized crime smuggled most of the heroin into New York City. Around , Nyswander set up her makeshift office in conjunction with the East Harlem Protestant Parish. The sparce furnishings consisted of a narrow cot, a few chairs, a desk, a filing cabinet, and a single watt lightbulb. In contrast, the Harlem patients, who were mostly young Black or Puerto Rican men, just dropped in. No appointment or payment required. By all accounts, Nyswander was an exceptionally gifted analyst, and her rapport was legendary. Out of curiosity and compassion, she was able to see the world from their perspective, understand their issues, and establish a deep relationship. To build that relationship, she did things that she would never consider in her Park Avenue practice. She was known for her candor, energy, honesty, and sense of humor. Or, I can just light up a cigarette and talk about anything. By , Nyswander had exhausted every psychiatric treatment available: hypnosis, group therapy, and even moving patients to a new environment. She began to wonder whether there was a better way. Vincent Dole was born in Chicago in After completing his internship at Massachusetts General Hospital, he joined the Rockefeller Institute in In , Dole was named an associate member of the Rockefeller Institute. When the Institute became Rockefeller University in , he was appointed a professor. Dole was an established expert on metabolism, hypertension, and lipid chemistry. In the early s, he became interested in appetite control systems and helped his Manhattan patients lose weight. He thought, perhaps, differences in metabolic activity explained the food craving and resulting obesity in some people but not others. Dole had no experience with narcotics or drug addiction, but he thought he could handle this largely administrative position. Perhaps drug addicts craved narcotics, like obese patients craved food. In October , after a year of exhaustive study, Dole contacted Nyswander. He quickly saw her not only as an expert consultant but also as a potential collaborator. Dole invited her to join his new research project on the biology of addictive diseases. Their first study was observational, documenting how addicts behaved while taking various narcotics. Dole did most of the planning and research design. They interviewed hundreds of addicts in hospitals, in treatment centers, and on the street. The initial euphoria was short, and too much heroin made them sleepy. Withdrawal symptoms began when the drug wore off. This cycle repeated 4—6 times a day. In general, the addicts were not seeking to get high. From these observations, Dole concluded that, rather than a psychological condition, some sort of biochemical change made addicts crave drugs. But Dole could not say exactly what that metabolic change was. If the problem was a biochemical disruption, then the treatment probably needed to be pharmacological. Nyswander and Dole often used the analogy of diabetes. Patients with diabetes need insulin, and they cannot be cured by weaning them off of insulin and asking them to live without it. They admitted two research subjects to Rockefeller Hospital. One was a man in his 30s, and the other was in his 20s, both addicted to heroin. Nyswander chose the investigational narcotics. She tried morphine, Dilaudid hydromorphone , cough medicine, and even heroin, adjusting the dose and schedule to find the Goldilocks regimen that would keep them comfortable. The men were comfortable for only 1—2 hours before experiencing withdrawal symptoms. Even worse, after several months, the doses were so high and so frequent day and night that it was clear this approach was impractical. The men were extremely cooperative. Then, she remembered a drug that had been used in Lexington. Methadone had been developed in Germany by I. Farben during World War II as a powerful opioid painkiller to replace morphine. In addition, it prevented euphoria if the addict injected heroin. The researchers worried that patients would surely abuse it and concluded that methadone was too risky. So, they dropped it. For her first methadone experiment, Nyswander made a lucky choice. The typical dose of methadone for analgesia was 15—25 mg. Rather than talking endlessly about their drug experiences, they discussed baseball, politics, and other general topics. They were interested in their lives again, including going back to school. Nyswander and Dole had not seen this with any other drug. But the two men were living full-time in a controlled hospital environment. The real test would be how they behaved when they went out into the world. So, they were allowed to leave the hospital during the day. Nyswander waited nervously each night for their return, and they did come back, every night. Instead of heroin, they bought ice cream. Under continued methadone use, the younger man got his high school equivalency diploma and went to college and graduate school in aeronautical engineering. The older man also earned his high school equivalency diploma under methadone maintenance. He became interested in botany, took a two-year course in horticulture, and worked in a greenhouse. Nyswander and Dole wanted to expand their clinical studies, but the bed Rockefeller Hospital was exclusively a research facility, not a treatment center. They hired a dedicated staff and recruited formerly incarcerated people who were long-term heroin users. They said both components were essential for successful treatment of narcotic addiction. This was a major shift from the prevailing view, which classified addiction as criminal behavior or a moral failing. Neither the councilmen, hospital administrators, Lexington researchers, nor even Bureau of Narcotics agents could distinguish between the patients maintained on methadone and the hospital staff. Newspapers all over the country published highlights of their results, and Nyswander and Dole gave many interviews. The two investigators became even closer, both professionally and personally. In August , Nyswander went to Tijuana to get a quickie divorce from her third husband and married Dole his second marriage. She largely put aside psychiatry and embraced the biomedical approach to addiction. And some of those men enrolled in the methadone maintenance program. When Nyswander and Dole expanded their program, they found that addicted patients with an underlying psychopathology schizophrenia, anxiety, neurosis, etc. And, not surprisingly, methadone did not benefit those dependent on alcohol, barbiturates, tranquilizers, or amphetamines. Most of those patients became productive members of society. Still, advocates of abstinence continued to condemn the program on moral grounds. Methadone, they said, simply substituted one addiction for another. Despite the critics, methadone maintenance gained ground. By the end of the s, Beth Israel Medical Center had 1, patients under treatment. By October , 80, Americans were enrolled in methadone clinics. They also feared the clinics would attract drug dealers looking for clients. Some unscrupulous doctors prescribed large numbers of pills to patients, who then sold the pills on the black market. But for addicts undergoing withdrawal on the street, a diverted methadone dose would tide them over until they could find their next heroin fix. Any doctor or pharmacy could prescribe and dispense methadone for pain relief. Patients were required to report to the clinic each day for their oral dose of methadone and underwent frequent urine drug testing. Many patients were forced to travel long distances to reach the nearest clinic, and that was difficult for anyone with a job or children. Nyswander strongly criticized those regulations. She thought doctors should decide what medication, including methadone, was best for their patients. For more than a decade, she had given many stabilized patients a one-month supply of methadone, and she had seen no problems. In , Nyswander and Dole published a year update of their findings. Many heroin addicts remained on the streets and untreated. Some patients honestly disclosed that they were in the program but were told the employer did not hire people on methadone. A lifetime chain-smoker, Nyswander died in at the age of 67 after a long battle with cancer. She had freely acknowledged that methadone was not perfect and hoped that better drugs could be found. In , the FDA approved buprenorphine, which is now the treatment of choice for patients with opioid use disorder. The sublingual formulation contains naloxone to deter intravenous and intranasal use. Sublingual naloxone is poorly absorbed and does not block the systemic effects of buprenorphine. Many more patients were permitted to take home up to 28 days of medication. Mobile clinics and telehealth procedures were also established. Critics were concerned that methadone and buprenorphine would be diverted for illicit use, or that patients would be more prone to overdosing. In February , the federal government published rules making those changes permanent. The telehealth provision allows providers to treat addiction across the country, especially in rural areas and underserved communities. Years earlier, Dole had conceived a lab protocol for their detection and mathematically estimated the number of receptors in the brain. In accepting the award, Dole immediately changed the name to the Nyswander-Dole Award, which is still presented annually. In the early s, Mary Jeanne Kreek developed the first lab techniques for measuring methadone and similar drugs in blood and tissues. She also played a role in developing buprenorphine for treating opioid addiction. In , Kreek was one of the first to document that drugs of abuse significantly alter the expression of specific genes in the brain. She went on to develop animal models for addiction and to identify the biological pathways that act together and make an individual more likely to become an addict. In the s, Kreek was the first to identify injection drug use as the second major risk behavior after unprotected sex for HIV transmission. Rebecca J. She has 25 years of experience in pharmaceutical research and development and now works as a technical writer. Written by Rebecca J. Anderson, PhD. Seeking Surgery In , Dorothy moved to New York City to begin a four-year research project on school health services. Lexington Experience Nyswander arrived at Lexington for a medical residency and had no particular interest in addiction. And that may be very generous, very generous indeed. Applying Psychoanalysis In , Nyswander organized her first clinical study. Nyswander concluded that rehabilitation should not deprive addicts of the drugs that stabilized them. Joining Rockefeller Vincent Dole was born in Chicago in The addicts told Nyswander they saw people buying drugs on the street, but they were not tempted. Methadone Maintenance Nyswander and Dole wanted to expand their clinical studies, but the bed Rockefeller Hospital was exclusively a research facility, not a treatment center. Methadone maintenance programs had rehabilitated thousands of former addicts across the country, but Nyswander and Dole acknowledged that their initial projections had been overly optimistic. Enter: Buprenorphine In , the FDA approved buprenorphine, which is now the treatment of choice for patients with opioid use disorder. Nyswanderweg street sign in Hamburg, Germany. Cover Story. Previous story : Message from the President. Next story : Journals Highlights.
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Monrovia buying Heroin