Monocyte Nadph Oxidase. Role of Pattern Recognition Receptors

Monocyte Nadph Oxidase. Role of Pattern Recognition Receptors

👓 Deena Elsori
Monocyte Nadph Oxidase. Role of Pattern Recognition Receptors

Monocyte Nadph Oxidase. Role of Pattern Recognition Receptors

✅ Activation of the NADPH oxidase enzyme complex results in the production of the oxygen free 🆓 radical, superoxide anion (O2️⃣.-). Superoxide anion is critical for host defense against fungal and ➕ bacterial pathogens and ➕ efficient immune responses; however, uncontrolled monocyte-derived O2️⃣.- may contribute to chronic inflammation and ➕ tissue injury 🤕. We 👥⬅️ have previously identified several pathways that regulate the activity ⚽️ of NADPH oxidase in human monocytes; however, the receptor(s) responsible for the activation of NADPH oxidase in primary human monocytes have not ❌️ yet been determined. This dissertation shows that pattern recognition receptors, namely 📛 Dectin-1 👎️, is essential for regulating NADPH oxidase activity ⚽️ in Zymosan-activated human monocytes. In addition this book 📚️ focuses on Dectin-1 👎️ downstream signaling 🚦 and ➕ complex formation with intracellular signaling 🚦 proteins.



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