Moms Little Helper

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How did benzodiazepines become the most widely prescribed class of drugs in the world in just a decade?
What a drag it is getting old
‘Kids are different today,’ I hear ev'ry mother say
Mother needs something today to calm her down
And though she’s not really ill
There's a little yellow pill
She goes running for the shelter of a mother’s little helper.
So begins the Stones’ 1966 hit ‘Mother’s Little Helper’, a dark and catchy paean to Valium. The words are a social commentary on benzodiazepines, which had just hit the market a few years prior and become wildly popular, particularly among American housewives.
Since the late 1800s, drug manufacturers had been hunting for a new, non-addictive anti-anxiety medication. Previously, patients were given opiates – with predictably disastrous results. Then came barbiturates, which were also written off as too addictive. After that, doctors began prescribing anti-psychotic drugs known as phenothiazines, but those drugs triggered severe side-effects such as uncontrollable facial movements.
In the 1950s, the late Leo Sternbach – a research chemist – began tinkering with an unknown class of compounds: the BZDs, or benzodiazepines. Over several years, he tested some 40 BZDs but all proved ineffective. Finally in 1956, after adding methylamine (a colourless gas derived from ammonia) to one compound, he produced a white powder that made mice sleepy and calm. The Food and Drug Administration approved Librium, the first-ever benzodiazepine, in 1960 and Valium in 1963. 
Benzodiazepines latch onto a receptor in the brain, which then activates a neighbouring neurotransmitter known as GABA. GABA release makes people calm and sleepy. The drugs can trigger that GABA rush in minutes, allowing a user to feel calmer almost immediately. Initially, benzodiazepines were hailed as a medical miracle, and they soon became the most widely prescribed class of drugs in the world. Even though the drugs’ addictive properties have now become clear, they remain widely available and are often prescribed for longer than the recommended 2–4 weeks.
Tolerance to the drugs is thought to develop because benzodiazepines weaken the response of receptors in the brain. That means a benzodiazepine user needs to keep ramping up the drug’s dosage to trigger the same calming effect of GABA. The drugs are also non-specific: they act on multiple subunits of GABA, which govern different actions, such as anxiety, restfulness, motor control and cognition. So even if a person goes on the drugs to alleviate social anxiety, they are invariably altering how they think, sleep and even move. That, in turn, explains why a person coming off benzodiazepines may experience wholly new symptoms, such as panic attacks and seizures.
Malcolm Lader, a psychologist and pharmacologist at King’s College London in the UK, began looking at the benzodiazepine craze as a young scientist in the 1970s. He initially assumed that most people on the drugs had ramped up their dose to such a degree that they had become hooked; instead, he found that users had largely remained on the prescribed dosage. “People couldn’t believe that you could still be on your original dose…and still have problems when you try to come off,” he recalls.
In the 1980s, Lader and a team of researchers issued one of the earliest warnings against long-term benzodiazepine use. Since that time, decades of evidence have made clear that taking benzodiazepines comes with serious risks, yet they remain hugely popular. Antidepressants (e.g. Prozac) and cognitive behaviour therapy are effective anxiety treatments, but neither act immediately; antidepressants can also initially worsen symptoms. For many people, benzodiazepines always seem like the better option.
If you could take the high out of drugs, what would be the point in taking them? Sujata Gupta meets the unorthodox doctor who thinks he can block some of the world’s most addictive pills.
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This article is about the song by the Rolling Stones. For the Once Upon a Time episode, see Mother's Little Helper (Once Upon a Time).
"Mother's Little Helper" is a song by the English rock band the Rolling Stones. It first appeared as the opening track to the United Kingdom version of their 1966 album Aftermath. It was released as a single in the United States and peaked at number eight on the Billboard Hot 100 singles chart in 1966.
15 April 1966 (UK album)
July 1966 (US single)
"Mother's Little Helper" / "Lady Jane"
(1966)
The song deals with the popularity of prescribed tranquilizers among housewives, and the potential hazards of overdose or addiction.[2] The drug in question is variously assumed to be meprobamate (Miltown)[3] or diazepam (Valium).[4]
Written by Mick Jagger and Keith Richards, "Mother's Little Helper" was recorded at the RCA Records studios in Hollywood, California, in March 1966.[5] According to the music historian Nicholas Schaffner, Jagger demonstrates "his crudest irony" on "Aftermath's most overt 'drug song'" … at a time when the adult media were beginning to rant about teenage drug abuse". Schaffner goes on to say "the Stones retaliated by zeroing in on all those harried middle-aged housewives incapable of getting through the day, or getting to sleep at night, without the help of their legally prescribed 'little yellow pills.'"[6]
The song begins with the line that is also heard as the last line in the repeated bridge section:
What a drag it is getting old
Kids are different today, I hear every mother say
Mother needs something today to calm her down
And though she's not really ill, there's a little yellow pill
She goes running for the shelter of a mother's little helper
And it helps her on her way, gets her through her busy day[7]
Toward the end of the song, the mothers are warned:
And if you take more of those, you will get an overdose
No more running for the shelter of a mother's little helper
They just helped you on your way, to your busy dying day[7]
The song is based around folksy chords and an eastern-flavoured guitar riff sounding like a sitar, but is a dual-slide riff played on two electric 12-string guitars by Brian Jones and Keith Richards.[8] Keith Richards has noted that the ending of the song was the idea of Bill Wyman, who also contributed a powerful and distinctive bass riff.[9]
Mick Jagger sings lead with Keith Richards on backing vocal; a previously unreleased (and presumably bootleg recording) mix features Keith more prominently on vocals.
"Mother's Little Helper" peaked at number eight on the Billboard Hot 100 chart in 1966. The single's B-side, "Lady Jane", reached number 24.[10]
Of the song's mainstream impact, Jason Mendelsohn of PopMatters writes that, "In pointing out the hypocrisy of a culture that tut-tuts rockers for recreational drug use while actively endorsing and prescribing mind-altering drugs to housewives, the Rolling Stones effectively cemented their reputation as a subversive cultural force."[11]
In 2005, American singer-songwriter Liz Phair covered "Mother's Little Helper" for the soundtrack album Music from and Inspired by Desperate Housewives.
^ Luhrssen, David; Larson, Michael (2017). Encyclopedia of Classic Rock. ABC-CLIO. p. 305. ISBN 9781440835148.
^ Brown, Nancy (1966-07-17). "Top Records Of The Week". The La Crosse Tribune. p. 34. Retrieved 2021-05-09.
^ Esther Inglis-Arkell. "This Is The Drug In The Rolling Stones' Song "Mother's Little Helper"". Io9.gizmodo.com. Retrieved 2016-09-29.
^ U.S. News and World Report, Vol. 127, p. 58 (1999): “A song on the 1967 Rolling Stones album Flowers was entitled ‘Mother's Little Helper,’ a tongue-in-cheek ode to a housewife coping with bratty kids and a demanding husband, thanks to Valium....”
^ Eder, Bruce (1989). Singles Collection: The London Years (Boxed set booklet). The Rolling Stones. New York City: ABKCO Records. p. 71. 1218-2.
^ Schaffner, Nicholas (1982). The British Invasion: From the First Wave to the New Wave. McGraw-Hill. p. 69. ISBN 0070550891.
^ a b Gilliland, John (1969). "The Rubberization of Soul: The great pop music renaissance" (audio). Pop Chronicles. University of North Texas Libraries. Track 5.
^ Guesdon, Margotin, Jean-Michel, Philippe (2016). The Rolling Stones All the Songs: The Story Behind Every Track. Black Dog & Leventhal Publishers Inc. ISBN 978-0316317740.
^ Ian McPherson. "Mother's Little Helper". Timeisonourside.com. Retrieved 2016-09-29.
^ Joel Whitburn (1985), The Billboard Book of Top 40 Hits, ISBN 0-8230-7518-4
^ Mendelsohn, Jason; Klinger, Eric (19 April 2013). "Counterbalance No. 125: The Rolling Stones' 'Aftermath'". PopMatters. Retrieved 28 March 2020.
^ "Top RPM Singles: Issue 5789." RPM. Library and Archives Canada. Retrieved 17 June 2016.
^ "Offiziellecharts.de – The Rolling Stones – Mother's Little Helper" (in German). GfK Entertainment Charts. Retrieved 17 June 2016.
^ "The Rolling Stones Chart History (Hot 100)". Billboard. Retrieved 17 June 2016.
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