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We have more newsletters. They are some of the greatest treasures the world has ever known, from priceless artworks to fabulous hoards of diamonds and vast reserves of gold. The Nazis plundered loot from across Europe, and, as they faced defeat in , frantically hid it from the advancing Allied forces. Some were stashed away while other pieces were smuggled out of Berlin by high-ranking Hitler henchmen to fund their own escapes and new lives. But as leading Nazis were killed or captured, the secret locations of much of the loot were lost forever. The collection, which included masterpieces by Picasso, Matisse and Chagall, had been hidden by Cornelius Gurlitt , the year-old son of an art dealer trusted by the Nazis to dispose of seized artworks. The US Holocaust Memorial Museum believes the Nazis seized as many 16, works of art as they pillaged their way across Europe during the s and s. The disguise failed and in October German soldiers dismantled the Amber Room and shipped the panels to Konigsberg Castle in East Prussia, where they went on display. What happened to them next remains shrouded in mystery. The German official in charge of the panels claimed they were placed in crates and stored in a castle that burned down during an air raid. But some experts believe the regime tried to ship the Amber Room out of the country, only for the ship carrying it to sink at the bottom of the Baltic Sea. Eyewitnesses claimed SS commandos sealed off the wood and dumped a secret cargo there early in Despite countless fortune hunters flocking there, the mine entrances have never been found. There was outrage last month when they started digging in a cemetery where 42 Holocaust victims are buried. The hoard was hidden to fund a terrorist group called Werewolf who would continue to take the fight to the Allies after the Nazis lost the Second World War. Lorry loads of gold were shipped out of Berlin in as the Red Army advanced and treasure hunters believe it was buried by Nazi labour battalions in the Leinawald forest near Leipzig in eastern Germany. The German government began digging for the lost gold in , but had to stop when poison gases from old mines began seeping to the surface. Treasure hunters are now targeting the area again and believe that one RAF reconnaissance photo shows sand workings that resemble the outline of a human skull and could point the way to the bunker. Few stories of missing Nazi loot have tantalised treasure hunters like the tales of billions of pounds worth of gold dumped in the Austrian lakes. During the final months of the war the SS dragged a stash of metal crates to the shores of Lake Toplitz, in the Salzkammergut region of Austria and dumped them into the icy waters. They found no gold, but they did find crates of counterfeit British pounds, secret documents and a printing press. However it is no easy task. The lake is a mile long, feet deep and full of submerged logs that make it a potential death trap. Reports have surfaced that another Nazi fortune may lie buried beneath the bed of Lake Stolpsee, a acre stretch of water north of Berlin. Nazi leader Hermann Goering reportedly ordered the gold to be dumped into the lake as the Red Army made its final push in One eyewitness reported seeing 30 concentration camp prisoners unloading heavy crates from lorries before ferrying them out to the middle of the lake and throwing them overboard. By Warren Manger Features Writer. Subscribe Please enter a valid email Something went wrong, please try again later. More Newsletters. This may include adverts from us and third parties based on our knowledge of you. More info. Thank you for subscribing! See Our Privacy Notice. Group Get daily headlines and breaking news alerts for FREE by signing up to our newsletter. Invalid email Something went wrong, please try again later. Sign Up No thanks, close. Show Me No thanks, close. See our Privacy Notice. And they have all been missing since the chaotic dying days of the Second World War. Story Saved. Follow Irish Mirror. Facebook Twitter. News all Most Read Most Recent Louth Gardai to begin dig for missing boy Kyran Durnin amid fears he died two years ago Exclusive - However, gardai fear that Kyran, who has two younger siblings, died over two years ago when he was just six and believe he was last seen alive in May Fury as Ryanair leaves passengers 'stranded' in tiny Irish airport amid Storm Ashley flight chaos. Kinahan gang. Associate of crime boss John Gilligan fighting for his life after hit-and-run collision. John Gilligan. Nurse died when car collided with motor caravan in Mayo. Cork Farmer who uprooted trees in act of 'barbarism' to learn his fate Daniel Finn claimed that he was 'improving the land for agriculture'. Dublin City Taskforce calls for 1, new Gardai as congestion charge ruled out. Workplace Relations Commission. Cork man who repeatedly raped teenage sister-in-law jailed for more than seven years. Most Read Most Recent Louth Gardai to begin dig for missing boy Kyran Durnin amid fears he died two years ago Exclusive - However, gardai fear that Kyran, who has two younger siblings, died over two years ago when he was just six and believe he was last seen alive in May Cruz Beckham 'smitten' with older girlfriend as he takes her to meet parents after true age revealed. Victoria Beckham. Conor McGregor gives glimpse inside luxury lifestyle after huge financial loss. Conor McGregor. Limerick Barbie Kardashian accused of making threats to kill or cause serious harm A jury has been sworn in. Conor McGregor responds to offer to be in corner opposite Khabib Nurmagomedov. Farmer who uprooted trees in act of 'barbarism' to learn his fate. Laois GAA. Top Stories. Crushing Ireland weather update from Met Eireann as storm passes but more dismal conditions loom. Liam Payne. 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Mittenwald where can I buy cocaine

By using our site, you agree to our collection of information through the use of cookies. To learn more, view our Privacy Policy. To browse Academia. Following the thalidomide disaster many accounts of pre-thalidomide drug safety history appeared. Some identified events which represented missed opportunities or ignored warning signs. This paper reviews three assertions made in these accounts; that an opportunity to introduce a spontaneous reporting system for suspected adverse drug reactions in was missed; that concerns about dangers of drugs in pregnancy identified in were ignored; and that a proposal to establish a drug regulatory body made in was abandoned. The paper concludes that even if all had been acted upon it is unlikely that the thalidomide disaster could have been entirely avoided. The tragic spectacle of thousands of infants born with deformed arms and legs at the beginning of the s stunned the entire globe. The medicine thalidomide, which pregnant women use for morning sickness and insomnia, was found to be responsible for the deformities in limbs and other organs. Thalidomide was sold in over 40 nations and was authorised for prescription usage in Canada from April to March Although the true number was likely greater due to spontaneous miscarriages and stillbirths, it resulted in around occurrences of deformities in this country. Due to its expulsion from the medical toolbox, this medication became a term of demeaning for many years. However, thalidomide has emerged from the darkness of unimaginable tragedy. Though under stringent restrictions, it has made a remarkable recovery and entered the current therapeutic regime Perhaps no other drug in modern medicine rivals the dramatic revitalization of thalidomide. Originally marketed as a sedative, thalidomide gained immense popularity worldwide among pregnant women because of its effective anti-emetic properties in morning sickness. Mounting evidence of human teratogenicity marked a dramatic fall from grace and led to widespread social, legal and economic ramifications. Despite its tragic past thalidomide emerged several decades later as a novel and highly effective agent in the treatment of various inflammatory and malignant diseases. In thalidomide completed its remarkable renaissance becoming the first new agent in over a decade to gain approval for the treatment of plasma cell myeloma. The catastrophic collapse yet subsequent revival of thalidomide provides important lessons in drug development. Never entirely abandoned by the medical community, thalidomide resurfaced as an important drug once the mechanisms of action were further studied and Journal of Alternatinative and Complementary Medicine, W hen George Santayana said, 'Those who K. Shapiro, said, were merely placebos because cannot remember the past are con-prior to the modem period, that is all that exdemned to repeat it,' he probably had political isted that could have worked effectively and economic history in mind. Present con- Shapiro, Henry F. Dowling was very ventional wisdom does not believe that science emphatic about the efficacy of early drugs older than a century could possibly contribute when he said, 'Less than two dozen effective any understanding to modern science. Often drugs were known before the year ' medical reports are considered 'history' if Dowling, Some doubt any effectiveness older than 5 years. When it comes to drugs, in respect to ancient or medieval medicine. Ancient and premod-Henderson, a prominent sociologist, opined em people had experiences with drugs and that prior to a random patient with a ranrecorded accurate observations about their dom disease and treated by a random physiphysiological reactions in humans and, more-cian had no better than a 5 chance of benover, they saw the dangers in the uses of some efiting from the encounter Barber, Many drugs. The history of drugs can inform us of people today would agree with the great 19th pharmaceutical uses that for various reasons century jurist, Oliver Wendell Holmes, who were forgotten but were once used by intelli-emphatically stated: 'I firmly believe that if the gent people in intelligent, effective ways. Ret-whole materia medica, as now used, could be rospective discovery can be a useful tool in sunk to the bottom of the sea, it would be all finding old drugs anew, and historical in-use the better for mankind-and all the worse for data can provide important clues about long-the fishes' Holmes, In brief, historical data can provide the basis for clinical observations although these data are difficult to access METHOD because of cultural differences, language barriers, divergent theoretical applications, and. Because past and present medicine was and above all, discordant scientific categories for is practiced more through dmg therapy than the comparisons. Most scientists, social scientists, and even massage, and physical therapy , the question of historians rejected the notion that old medicine the effectiveness of dmgs throughout history is and even older medicines could have any util-absolutely central to medicine's role. More of toitarian use, only antiquarian indulgence. Old day's dmgs than Dowling's 2 dozen come from drugs, as one leading pharmacologist, Arthur historically used herbs. Examples of dmgs used. Thalidomide was originally used as a Wonder Drug to treat morning sickness and insomnia in pregnant women in late s. It became apparent in early s that thalidomide treatment resulted in severe birth defects in thousands of children. Then it was banned in most of countries. Later on discovered anti-inflammatory and anti-angiogenic properties of Thalidomide proved to be useful for treatment of leprosy and multiple myeloma. A series of immunomodulatory drugs created by chemical modification of thalidomide have been developed to overcome the original devastating side effects. We briefly review pharmacological and the therapeutic profile of thalidomide. Its active principle was chemically related to the Thalidomide molecule, which proved to cause malformations in thousands of newborn children and to have neurotoxic effects in adults. Furthermore, Doriden was being sold in direct competition with Contergan Thalidomide. This makes Doriden an interesting case study to gain new insight into drug marketing, as well as into risk perception and risk management before and during the Thalidomide disaster. A sulfa drug called Elixir Sulfanilamide released in killed over Americans, mostly children. A sedative called Thalidomide released in Europe in and taken by pregnant women caused deformities in 10, children. These famous episodes strike us as horrible injustices that must be prevented. Journal of Pharmacological and Toxicological Methods, Log in with Facebook Log in with Google. Remember me on this computer. Enter the email address you signed up with and we'll email you a reset link. Need an account? Click here to sign up. The Dawn of Drug safety Myles Stephens. Related papers Opportunities missed, warnings ignored: re-discovering the history of drug safety in Great Britain following the thalidomide disaster Stuart Anderson. Thalidomide: The journey from curse to boon Amol sawale. The rise, fall and subsequent triumph of thalidomide: lessons learned in drug development Hillard M Lazarus. Forgive sins: rise of thalidomide Piotr Brzezinski. Response of safety pharmacologists to challenges arising from the rapidly evolving changes in the pharmaceutical industry Michael K Pugsley.

Mittenwald where can I buy cocaine