Mitsui Jun Shota Porn
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Affiliations
1 Department of Neurology, The University of Tokyo Hospital, Tokyo, Japan.
2 Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.
3 Advanced Genomics Center, National Institute of Genetics, Shizuoka, Japan.
4 Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
5 Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
6 Department of Laboratory Medicine, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan.
7 Human Disease Genomics, Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
8 Department of Neurology, Kyorin University, Tokyo, Japan.
9 Department of Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan.
10 Department of Neurology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
11 Department of Neurology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
12 Department of Neurology, Nishi-Niigata Chuo National Hospital, Niigata, Japan.
13 Department of Psychiatry, Toyosato Hospital, Ibaraki, Japan.
14 Department of Epilepsy, Nishi-Niigata Chuo National Hospital, Niigata, Japan.
15 Division of Cardiology, National Hospital Organization Takasaki General Medical Center, Gunma, Japan.
16 Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
17 Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
18 Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.
19 Department of Neurology, Tachikawa General Hospital, Niigata, Japan.
20 Department of Neurology, Sannocho Hospital, Niigata, Japan.
21 Department of Neurology, Sado General Hospital, Niigata, Japan.
22 Department of Neurology, Niigata Medical Center, Niigata, Japan.
23 Department of Psychiatry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
24 Department of Neurology, Kurashikikinen Hospital, Okayama, Japan.
25 Department of Neurology, Jichi Medical University, Saitama Medical Center, Saitama, Japan.
26 Department of Neurology, International University of Health and Welfare, Tochigi, Japan.
27 Third Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
28 Department of Neurology, School of Medicine, Kitasato University, Kanagawa, Japan.
29 Department of Cell Physiology, School of Medicine, Kyorin University, Tokyo, Japan.
30 Department of Neurology, Fukushima Medical University, Fukushima, Japan.
31 Department of Neurology, University of Yamanashi, Yamanashi, Japan.
32 Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.
33 Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan.
34 Department of Neurology, Neurological Institute, Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
35 Department of Neurology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
36 Hiratsuka Hospital, Kanagawa, Japan.
37 Epilepsy Hospital Bethel Japan, Miyagi, Japan.
38 Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
39 Department of Neurology, International University of Health and Welfare Mita Hospital, Tokyo, Japan.
40 Department of Neurology, The University of Tokyo Hospital, Tokyo, Japan. tsuji@m.u-tokyo.ac.jp.
41 Medical Genome Center, The University of Tokyo Hospital, Tokyo, Japan. tsuji@m.u-tokyo.ac.jp.
42 International University of Health and Welfare, Chiba, Japan. tsuji@m.u-tokyo.ac.jp.
Hiroyuki Ishiura et al. Nat Genet. 2018 Apr.
Affiliations
1 Department of Neurology, The University of Tokyo Hospital, Tokyo, Japan.
2 Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.
3 Advanced Genomics Center, National Institute of Genetics, Shizuoka, Japan.
4 Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
5 Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
6 Department of Laboratory Medicine, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan.
7 Human Disease Genomics, Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
8 Department of Neurology, Kyorin University, Tokyo, Japan.
9 Department of Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan.
10 Department of Neurology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
11 Department of Neurology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
12 Department of Neurology, Nishi-Niigata Chuo National Hospital, Niigata, Japan.
13 Department of Psychiatry, Toyosato Hospital, Ibaraki, Japan.
14 Department of Epilepsy, Nishi-Niigata Chuo National Hospital, Niigata, Japan.
15 Division of Cardiology, National Hospital Organization Takasaki General Medical Center, Gunma, Japan.
16 Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
17 Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
18 Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.
19 Department of Neurology, Tachikawa General Hospital, Niigata, Japan.
20 Department of Neurology, Sannocho Hospital, Niigata, Japan.
21 Department of Neurology, Sado General Hospital, Niigata, Japan.
22 Department of Neurology, Niigata Medical Center, Niigata, Japan.
23 Department of Psychiatry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
24 Department of Neurology, Kurashikikinen Hospital, Okayama, Japan.
25 Department of Neurology, Jichi Medical University, Saitama Medical Center, Saitama, Japan.
26 Department of Neurology, International University of Health and Welfare, Tochigi, Japan.
27 Third Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
28 Department of Neurology, School of Medicine, Kitasato University, Kanagawa, Japan.
29 Department of Cell Physiology, School of Medicine, Kyorin University, Tokyo, Japan.
30 Department of Neurology, Fukushima Medical University, Fukushima, Japan.
31 Department of Neurology, University of Yamanashi, Yamanashi, Japan.
32 Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.
33 Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan.
34 Department of Neurology, Neurological Institute, Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
35 Department of Neurology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
36 Hiratsuka Hospital, Kanagawa, Japan.
37 Epilepsy Hospital Bethel Japan, Miyagi, Japan.
38 Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
39 Department of Neurology, International University of Health and Welfare Mita Hospital, Tokyo, Japan.
40 Department of Neurology, The University of Tokyo Hospital, Tokyo, Japan. tsuji@m.u-tokyo.ac.jp.
41 Medical Genome Center, The University of Tokyo Hospital, Tokyo, Japan. tsuji@m.u-tokyo.ac.jp.
42 International University of Health and Welfare, Chiba, Japan. tsuji@m.u-tokyo.ac.jp.
Epilepsy is a common neurological disorder, and mutations in genes encoding ion channels or neurotransmitter receptors are frequent causes of monogenic forms of epilepsy. Here we show that abnormal expansions of TTTCA and TTTTA repeats in intron 4 of SAMD12 cause benign adult familial myoclonic epilepsy (BAFME). Single-molecule, real-time sequencing of BAC clones and nanopore sequencing of genomic DNA identified two repeat configurations in SAMD12. Intriguingly, in two families with a clinical diagnosis of BAFME in which no repeat expansions in SAMD12 were observed, we identified similar expansions of TTTCA and TTTTA repeats in introns of TNRC6A and RAPGEF2, indicating that expansions of the same repeat motifs are involved in the pathogenesis of BAFME regardless of the genes in which the expanded repeats are located. This discovery that expansions of noncoding repeats lead to neuronal dysfunction responsible for myoclonic tremor and epilepsy extends the understanding of diseases with such repeat expansion.
Wood H. Wood H. Nat Rev Neurol. 2018 May;14(5):251. doi: 10.1038/nrneurol.2018.37. Epub 2018 Mar 23. Nat Rev Neurol. 2018. PMID: 29569625 No abstract available.
van Blitterswijk M, Rademakers R. van Blitterswijk M, et al. Nat Genet. 2018 Apr;50(4):477-478. doi: 10.1038/s41588-018-0093-0. Nat Genet. 2018. PMID: 29632377 No abstract available.
Scheffer IE. Scheffer IE. Epilepsy Curr. 2018 Jul-Aug;18(4):238-239. doi: 10.5698/1535-7597.18.4.238. Epilepsy Curr. 2018. PMID: 30254519 Free PMC article. No abstract available.
Cen Z, Chen Y, Yang D, Zhu Q, Chen S, Chen X, Wang B, Xie F, Ouyang Z, Jiang Z, Fu A, Hu B, Yin H, Qiu X, Yu F, Du X, Hao W, Liu Y, Wang H, Wang L, Yu X, Xiao Y, Liu C, Xiao J, Zhou Y, Yang W, Zhang B, Luo W. Cen Z, et al. Mov Disord. 2019 Oct;34(10):1571-1576. doi: 10.1002/mds.27832. Epub 2019 Sep 4. Mov Disord. 2019. PMID: 31483537
Lei XX, Liu Q, Lu Q, Huang Y, Zhou XQ, Sun HY, Wu LW, Cui LY, Zhang X. Lei XX, et al. Eur J Neurol. 2019 Mar;26(3):513-518. doi: 10.1111/ene.13848. Epub 2018 Nov 30. Eur J Neurol. 2019. PMID: 30351492
Zeng S, Zhang MY, Wang XJ, Hu ZM, Li JC, Li N, Wang JL, Liang F, Yang Q, Liu Q, Fang L, Hao JW, Shi FD, Ding XB, Teng JF, Yin XM, Jiang H, Liao WP, Liu JY, Wang K, Xia K, Tang BS. Zeng S, et al. J Med Genet. 2019 Apr;56(4):265-270. doi: 10.1136/jmedgenet-2018-105484. Epub 2018 Sep 7. J Med Genet. 2019. PMID: 30194086
Lagorio I, Zara F, Striano S, Striano P. Lagorio I, et al. Seizure. 2019 Apr;67:73-77. doi: 10.1016/j.seizure.2019.03.009. Epub 2019 Mar 19. Seizure. 2019. PMID: 30928698 Review.
Hitomi T, Takahashi R, Ikeda A. Hitomi T, et al. Rinsho Shinkeigaku. 2014;54(12):1142-5. doi: 10.5692/clinicalneurol.54.1142. Rinsho Shinkeigaku. 2014. PMID: 25672731 Review. Japanese.
Ishiguro T, Nagai Y, Ishikawa K. Ishiguro T, et al. Front Neurosci. 2021 May 25;15:648133. doi: 10.3389/fnins.2021.648133. eCollection 2021. Front Neurosci. 2021. PMID: 34113230 Free PMC article. Review.
Chintalaphani SR, Pineda SS, Deveson IW, Kumar KR. Chintalaphani SR, et al. Acta Neuropathol Commun. 2021 May 25;9(1):98. doi: 10.1186/s40478-021-01201-x. Acta Neuropathol Commun. 2021. PMID: 34034831 Free PMC article. Review.
Sun H, Shen XR, Fang ZB, Jiang ZZ, Wei XJ, Wang ZY, Yu XF. Sun H, et al. Life (Basel). 2021 Apr 19;11(4):361. doi: 10.3390/life11040361. Life (Basel). 2021. PMID: 33921670 Free PMC article. Review.
Courage C, Oliver KL, Park EJ, Cameron JM, Grabińska KA, Muona M, Canafoglia L, Gambardella A, Said E, Afawi Z, Baykan B, Brandt C, di Bonaventura C, Chew HB, Criscuolo C, Dibbens LM, Castellotti B, Riguzzi P, Labate A, Filla A, Giallonardo AT, Berecki G, Jackson CB, Joensuu T, Damiano JA, Kivity S, Korczyn A, Palotie A, Striano P, Uccellini D, Giuliano L, Andermann E, Scheffer IE, Michelucci R, Bahlo M, Franceschetti S, Sessa WC, Berkovic SF, Lehesjoki AE. Courage C, et al. Am J Hum Genet. 2021 Apr 1;108(4):722-738. doi: 10.1016/j.ajhg.2021.03.013. Am J Hum Genet. 2021. PMID: 33798445
Castelli LM, Huang WP, Lin YH, Chang KY, Hautbergue GM. Castelli LM, et al. Biochem Soc Trans. 2021 Apr 30;49(2):775-792. doi: 10.1042/BST20200690. Biochem Soc Trans. 2021. PMID: 33729487 Free PMC article.
By Daily Mail.com Reporters 01:08 BST 13 Mar 2019 , updated 07:16 BST 14 Mar 2019
The twisted nature of Michael Jackson's sizable and bizarre pornography collection was revealed in images released to the media in 2016.
The huge cache of videos, books and images found at his Neverland Ranch in 2003 - six years before he died - was noted in a Santa Barbara Sheriff's Department report.
It featured women and men in scenes of bondage, transgender videos, young male erotica featuring men and teenagers and even scenes of same-sex sadomasochism.
In another odd image a child beauty queen stands with a noose around her neck while standing in front of an image of child beauty queen JonBenét Ramsey.
Much of the material was also detailed in court papers from the time, submitted after a young boy came forward claiming that he had been sexually abused and assaulted by the singer on multiple occasions.
The police report claims that in Jackson's bedroom and bathroom alone there were at least seven collections of work found by investigators that show boys in their teenage years - and in some cases younger - fully nude or partially clothed.
One of the collections, Taormina Wilhelm Von Gloeden, is described in court papers as: 'Nude photos of teenage boys from late 1800s.'
Then there were Polaroids of two juvenile males.
'One of the juveniles appeared to be a young teenager; the other appeared to be adolescent (pre-teen),' stated the report.
'The name 'Greg' was printed above the child who appeared to be off teenage years. This subject appeared to be wearing a white terry cloth robe.
'The name 'Kendall' was printed over the adolescent aged individual. The adolescent individual was bare chested.
'The picture does not depict the lower half of the children so it cannot be ascertained as to what they were wearing with regard to lower clothing.'
The reported later noted when describing these photos: 'The phrases 'Are you scared yet?' and 'Ha! Ha!' were printed on the lower portion of the picture.'
There were more photos of those two boys found in another box of photos, this time alongside Jackson himself.
'Again, these individuals were posed in provocative manners with bare chests,' said the report.
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See the moment sheriffs raid Jackson's Neverland ranch in 2003
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The search of the home occurred in November of that year while Jackson was in Las Vegas, with 70 members of the Santa Barbara County District Attorney's Office and Sheriff's Department turning up to the residence.
An arrest warrant had been issued at that time as well, and Jackson later turned himself into police when he returned to California.
Radar Online first obtained the police report and court papers, and an investigator on the case told them: 'The documents exposed Jackson as a manipulative, drug-and-sex-crazed predator who used blood, gore, sexually explicit images of animal sacrifice and perverse adult sex acts to bend children to his will.'
The source added: 'He also had disgusting and downright shocking images of child torture, adult and child nudity, female bondage and sadomasochism.'
The report states that many of the materials featuring naked men and women in the home could be used for the purpose of trying to attract young men or boys.
After the descriptions for many of the materials, the investigator notes: 'Based on my training, this type of material can be used as part of the 'grooming' process, by which people (those seeking to molest children) lower the inhibitions of their intended victims and facilitate the molestation of said victims.'
These materials include 'a book depicting nude children' found in the singer's 'arcade room'; 'a book which contained nude photographs of men' in the 'master bathroom'; and multiple books found in the 'master bedroom' that included one with 'naked and semi-naked gay men' and another with 'pre-teen or early teenage individuals' who in some cases were 'nude or semi-nude.'
Radar spoke with Santa Barbara Senior Assistant District Attorney Ron Zonen about the case as he was part of the prosecution team that took on Jackson in court.
'A lot of this stuff was used to desensitize the children, and Michael admitted taking one child after another into bed with him for long periods of time,' said Zonen.
'We identified five different boys, who all made allegations of sexual abuse. There's not much question in my mind that Michael was guilty of child molestation.'
Jackson was ultimately acquitted in 2005 after being charged with seven felony counts of child molestation and two felony counts of providing an intoxicant to a minor under the age of 14 when Gavin Arvizo came forward claiming that he had been sexually assaulted by the singer.
Gavin was a 13-year-old cancer survivor at the time of the alleged incidents.
The claims made by Gavin were similar to the ones made a decade earlier when another 13-year-old boy, Jordan Chandler, came forward to say he had been molested by Jackson.
No charges were ever filed against the singer however after police discovered the Chandler's father may have been attempting to extort Jackson and the young boy's mother claimed Jackson never touched her son.
Jordan however was able to perfectly describe Jackson's buttocks, pubic hair, and distinctive marks on both his testicles and penis.
The mark on the penis could only be seen if it was lifted
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Expansions of intronic TTTCA and TTTTA repeats in benign ...
Michael Jackson's twisted pornography collection and you…
Michael Jackson's twisted pornography collection and you…
Mitsui Jun Shota Porn
