Митрагинин — WiKi

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Митрагинин — WiKi

Mitragynine is an indole -based opioid-receptor agonist and the most abundant active alkaloid in the plant Mitragyna speciosa , commonly known as kratom \\\\\\\\\\\\\\\\\[1\\\\\\\\\\\\\\\\\] and biak-biak. The general subjective effects of mitragynine have been summarized in various reviews and include improved mood and analgesia, with some subjects experiencing relaxation and others stimulation paradoxical effects. Research on mitragynine structure—activity relationships lead to discovery of new potent opioid agonists, notably some Chalogen and 2,3-ethylene glycol bridged derivatives of 7-hydroxymitragynine. The most potent one is the fluoro ethylene glycol adduct of 7-hydroxymitragynine with a potency 4-fold higher than 7-hydroxymitragynine. Other modification lead to 2,3-dihydro derivatives such as MGM, prepared by reduction of 7-hydroxymitragynine with sodium borohydride. The antinociceptive effect of MGM is approximately 15 and 50 times more potent than that of morphine after subcutaneous and oral administration. Mitragynine has been studied in chronic users. It undergoes extensive hepatic metabolism with linear kinetics and long half life. Detection in body fluids is typically by liquid chromatography-mass spectrometry. It is structurally related to yohimbine but shows a totally different pharmacology. The first total synthesis of mitragynine was reported by Takayama et al. From Wikipedia, the free encyclopedia. Curr Top Med Chem. Raffa - Kratom and Other Mitragynines: Drug Design, Development and Therapy. Journal of Analytical Toxicology. Disposition of toxic drugs and chemicals in man. Agonists abridged; see here for a full list: Retrieved from ' https: Views Read Edit View history. In other projects Wikimedia Commons. This page was last edited on 12 September , at By using this site, you agree to the Terms of Use and Privacy Policy.

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