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Background: Degeneration of central neurons and fibers has been observed in postmortem brains of heroin dependent patients. However, there are no biomarkers to predict the severity of neurodegeneration related to heroin dependence. A correlation has been reported between inflammatory C-C motif chemokine ligand 11 CCL11, or eotaxin-1 and neurodegeneration in Alzheimer's disease. Methods: Three-hundred-forty-four heroin dependent, Taiwanese patients under methadone maintenance treatment MMT were included with clinical assessment and genomics information. Eighty-seven normal control subjects were also recruited for comparison. Patients 45 years of age or older had significantly higher plasma levels of CCL11, fibroblast growth factor 2 FGF-2 , nicotine metabolite cotinine, and a longer duration of addiction. Conclusions: The results suggest possible novel mechanisms mediated through CCL11 involving neurotoxicity in heroin dependent patients. Abstract Background: Degeneration of central neurons and fibers has been observed in postmortem brains of heroin dependent patients. Publication types Research Support, Non-U.
Suicide attempts and death among heroin-involved women seeking methadone treatment in Taiwan
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Suicide attempts and death among heroin-involved women seeking methadone treatment in Taiwan
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Suicide attempts and death among heroin-involved women seeking methadone treatment in Taiwan
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