Мезокарб — Википедия РУ

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Мезокарб — Википедия РУ

The drug was originally developed in the USSR in the s \\\\\\\\\\\\[2\\\\\\\\\\\\] \\\\\\\\\\\\[3\\\\\\\\\\\\] for a variety of indications including asthenia , apathy , adynamia and some clinical aspects of depression and schizophrenia. The drug has been found to act as a selective dopamine reuptake inhibitor by blocking the actions of the dopamine transporter DAT , \\\\\\\\\\\\[13\\\\\\\\\\\\] \\\\\\\\\\\\[14\\\\\\\\\\\\] and lacks the dopamine release characteristic of stimulants such as dextroamphetamine. Mesocarb was sold in Russia as 5 milligram tablets under the brand name Sydnocarb. Hydroxylated metabolites can be detected in urine for up to 10 days after consumption. The drug is almost unknown in the western world and is neither used in medicine or studied scientifically to any great extent outside Russia and other countries in the former Soviet Union. It has however been added to the list of drugs under international control and is a scheduled substance in most countries, despite its multiple therapeutic applications and reported lack of significant abuse potential. Mesocarb had erroneously been referred to as a prodrug of amphetamine \\\\\\\\\\\\[20\\\\\\\\\\\\] but this was based on older literature that relied on gas chromatography as an analytical method. Subsequently, with the advent of mass spectroscopy, it has been shown that presence of amphetamine in prior studies was an artifact of gas chromatography method. Mesocarb is a mesoionic sydnone imine. It has the amphetamine-backbone present, except that the R N has a complicated imine side-chain present. From Wikipedia, the free encyclopedia. IUPAC name. Interactive image. J Pharmacol Exp Ther. Vopr Med Khim. Biull Eksp Biol Med in Russian. Kosm Biol Aviakosm Med in Russian. Eksp Klin Farmakol in Russian. Pol J Pharmacol Pharm. The Journal of Pharmacology and Experimental Therapeutics. Pharmacol Biochem Behav. Ann N Y Acad Sci. Eur J Pharmacol. J Chromatogr Sci. Hung Pharmacotherapy in Russian. Verhoff; Harald F. Forensic Medicine: Fundamentals and Perspectives. Journal of Chromatography B. Adapromine Amantadine Bromantane Memantine Rimantadine. Oxiracetam Phenylpiracetam Phenylpiracetam hydrazide. ATC code : N06B. ADHD pharmacotherapies. Amphetamine Mixed amphetamine salts , Levoamphetamine , Dextroamphetamine , Lisdexamfetamine Methamphetamine Methylphenidate Dexmethylphenidate. Atomoxetine Modafinil. Clonidine Guanfacine. Amantadine Carbamazepine. Monoamine reuptake inhibitors. Others: Antihistamines e. Others: A Amoxapine Antihistamines e. Amiodarone Amphetamines e. Namespaces Article Talk. Views Read Edit View history. By using this site, you agree to the Terms of Use and Privacy Policy.

Мезокарб — Википедия РУ

The drug was originally developed in the USSR in the s \\\\\\\\\\\\\\[2\\\\\\\\\\\\\\] \\\\\\\\\\\\\\[3\\\\\\\\\\\\\\] for a variety of indications including asthenia , apathy , adynamia and some clinical aspects of depression and schizophrenia. The drug has been found to act as a selective dopamine reuptake inhibitor by blocking the actions of the dopamine transporter DAT , \\\\\\\\\\\\\\[13\\\\\\\\\\\\\\] \\\\\\\\\\\\\\[14\\\\\\\\\\\\\\] and lacks the dopamine release characteristic of stimulants such as dextroamphetamine. Mesocarb was sold in Russia as 5 milligram tablets under the brand name Sydnocarb. Hydroxylated metabolites can be detected in urine for up to 10 days after consumption. The drug is almost unknown in the western world and is neither used in medicine or studied scientifically to any great extent outside Russia and other countries in the former Soviet Union. It has however been added to the list of drugs under international control and is a scheduled substance in most countries, despite its multiple therapeutic applications and reported lack of significant abuse potential. Mesocarb had erroneously been referred to as a prodrug of amphetamine \\\\\\\\\\\\\\[20\\\\\\\\\\\\\\] but this was based on older literature that relied on gas chromatography as an analytical method. Subsequently, with the advent of mass spectroscopy, it has been shown that presence of amphetamine in prior studies was an artifact of gas chromatography method. Mesocarb is a mesoionic sydnone imine. It has the amphetamine-backbone present, except that the R N has a complicated imine side-chain present. From Wikipedia, the free encyclopedia. IUPAC name. Interactive image. J Pharmacol Exp Ther. Vopr Med Khim. Biull Eksp Biol Med in Russian. Kosm Biol Aviakosm Med in Russian. Eksp Klin Farmakol in Russian. Pol J Pharmacol Pharm. The Journal of Pharmacology and Experimental Therapeutics. Pharmacol Biochem Behav. Ann N Y Acad Sci. Eur J Pharmacol. J Chromatogr Sci. Hung Pharmacotherapy in Russian. Verhoff; Harald F. Forensic Medicine: Fundamentals and Perspectives. Journal of Chromatography B. Adapromine Amantadine Bromantane Memantine Rimantadine. Oxiracetam Phenylpiracetam Phenylpiracetam hydrazide. ATC code : N06B. ADHD pharmacotherapies. Amphetamine Mixed amphetamine salts , Levoamphetamine , Dextroamphetamine , Lisdexamfetamine Methamphetamine Methylphenidate Dexmethylphenidate. Atomoxetine Modafinil. Clonidine Guanfacine. Amantadine Carbamazepine. Monoamine reuptake inhibitors. Others: Antihistamines e. Others: A Amoxapine Antihistamines e. Amiodarone Amphetamines e. Namespaces Article Talk. Views Read Edit View history. By using this site, you agree to the Terms of Use and Privacy Policy.

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Мезокарб — Википедия РУ

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