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Reportedly, it has been sold since around as a designer drug. Incidences of psychological and physical harm have been attributed to MDPV use. The hydrochloride salt exists as a very fine, hygroscopic, crystalline powder that tends to clump to itself, resembling something like powdered sugar. Its color can range from pure white to a yellowish-tan and has a slight odor that strengthens as it colors. Impurities are likely to consist of either pyrollidine or alpha-dibrominated alkylphenones from either excess pyrollidine or incomplete amination, respectively, during synthesis and likely accounts for its discoloration and fishy pyrollidine or bromine-like odor, which worsens upon exposure to air, moisture, or bases. MDPV acts as a stimulant and has been reported to produce effects similar to those of cocaine , methylphenidate , and amphetamines. Psychiatric symptoms may persist. Physical symptoms may progress to rhabdomyolysis , renal failure, seizures, high anion gap metabolic acidosis, respiratory failure, or liver failure. The primary psychological effects have a duration of roughly 3 to 4 hours, with after effects such as tachycardia , hypertension , and mild stimulation lasting from 6 to 8 hours. Extended binges on MDPV have also been reported to produce severe comedown syndrome similar to that of methamphetamine \\\\\\\\\\\\\\[ citation needed \\\\\\\\\\\\\\] , characterized by depression , lethargy, headache , anxiety , postural hypotension lightheadedness and weakness of the muscles , and in some cases severely bloodshot eyes, which usually subside within 4 to 8 hours. MDPV may also cause temporary bruxism. Side effects are highly dose-dependent. No fatalities have so far been reported without the combination of other substances except for suicide. Reported modalities of intake include oral consumption, insufflation , smoking , rectal and intravenous use. MDPV can be prepared by modifying the alkylation-oxidation-bromination-amination route to cathinone analogs. This involves a Grignard alkylation of piperonal , oxidation of the resulting secondary alcohol back into a ketone , alpha halogenation of the aromatic ketone with bromine, and subsequent amination with pyrrolidine. Such brominated halo are of particular concern to eukaryote macro-biological organisms, and special consideration must be made when preparing MDPV for purposes of long-term biological testing on lab animals, especially in mammals, and especially where the possibility exists for diversion and subsequent ingestion by humans for recreational purposes. Preparation for biological purposes and testing must ensure a complete and through workup , including several washes with saturated NaHCO3 \\\\\\\\\\\\\\[ 6 \\\\\\\\\\\\\\] solution after washing with water to remove the brominated intermediates before final salting of the freebase for recrystallization. Aside from the bromine ion being highly electronegative and reactive, the alkyl - bromine compounds often being alkylating agents, and brominated aromatic derivatives being implicated as hormone disruptors , there also exists the mechanism for bromine substituting for the methyl group in the nitrogenous base 5-methyluracil of DNA , creating the base-analog 5-bromouracil , which can be incorporated into DNA and induce a point mutation via base substitution. Molecularly, this is seen as demethylenation of methylenedioxypyrovalerone CYP2D6 , followed by methylation of the aromatic ring via catechol-O-methyl transferase. Then hydroxylation of both the aromatic ring and side chain takes place followed by and oxidation of the pyrimidine ring to the corresponding lactam , with subsequent detachment and ring opening to the corresponding carboxylic acid. See list of drugs illegal in the UK for more information. Schedule I status is reserved for those substances with a high potential for abuse, no currently accepted use for treatment in the United States and a lack of accepted safety for use of the drug under medical supervision. Prior to the Federal ban being announced, it was already banned in in Louisiana \\\\\\\\\\\\\\[ 1 \\\\\\\\\\\\\\] and Florida. It also makes it a Class A misdemeanor to sell the drug, and a Class B misdemeanor to possess it. On May 5, , Tennessee Governor Bill Haslam signed a law making it a crime to knowingly produce, manufacture, distribute, sell, offer for sale or possess with intent to produce, manufacture, distribute, sell, or offer for sale any product containing 3,4-Methylenedioxypyrovalerone MDPV. On July 6, , the governor of Maine signed a bill establishing fines for possession and penalties for trafficking of MDPV. The substances will be illegal to possess and sell for 12 months until the DEA and Department of Health and Human Services DHS determines if these substances should be permanently banned. It is currently legal to own, sell, purchase and possess. Possession of the fictional substance 'Methyenedioxypyrovalerone' is a misdemeanor, while selling is a felony, inventing it may carry harsher penalties. In April , two weeks after they went missing, two men in Warren County, Pennsylvania, were found dead in the Allegheny National Forest. The official cause of death of both men was hypothermia , but toxicology reports later confirmed that both Troy Johnson, 29, and Terry Sumrow, 28, had ingested MDPV shortly before their deaths. MDPV containers were found in their vehicle along with spoons, hypodermic syringes and marijuana paraphernalia. One person was reported dead on arrival at the ED. Associates of the dead person reported he had used bath salts. His toxicology results revealed high levels of MDPV in addition to marijuana and prescription drugs. The primary factor contributing to death was cited as MDPV toxicity after autopsy was performed. Anyone suspected of having taken MDPV and needing possible treatment should be immediately referred to their personal physician or the nearest poison control center. Treatment in the emergency department for severe hypertension, tachycardia, agitation, or seizures consists of large doses of lorazepam in 2 - 4 mg increments every 10—15 minutes intravenously or intramuscularly. If this is not effective, haloperidol is an alternative treatment. It has been found that the use of any beta blockers to treat hypertension in these patients can cause an unopposed peripheral alpha-adrenergic effect with a dangerous paradoxical rise in blood pressure. Dopamine reuptake inhibitor — Dopamine A dopamine reuptake inhibitor DRI, DARI is a type of drug that acts as a reuptake inhibitor for the neurotransmitter dopamine by blocking the action of the dopamine transporter DAT. Designer drug — Not to be confused with Drug design. Dopaminergic — Main article: Mephedrone — Not to be confused with methedrine, methedrone, methadone, or methylone. Amphetamine — For other uses, see Amphetamine disambiguation. Retrieved 16 May Identification and formation of novel cathinones'. A designer drug with alpha-pyrrolidinophenone structure'. Forensic Science International 1—3: Loose Leaf Version of Microbiology: Retrieved 25 June Rapid Communications in Mass Spectrometry 24 Journal of Mass Spectrometry 45 Retrieved 25 January Retrieved June 12, Retrieved May 22, Beshear signs law banning new synthetic drugs. Retrieved Wednesday, March 23, The law is named after Pamela Schmidt, a University student who was murdered in March. Authorities believe her boyfriend William Parisio Jr. Retrieved 7 July Morbidity and Mortality Weekly Report 60 Synthetic drugs send thousands to ER'. The New York Times. Selective norepinephrine reuptake inhibitors: Aromatic ketones Benzodioxoles Cathinones Norepinephrine-dopamine reuptake inhibitors Pyrrolidinophenones. Look at other dictionaries: Dictionaries export , created on PHP,. Mark and share Look up in the dictionary Browse synonyms Search through all dictionaries Translate… Search Internet Search in the same category. RS Benzo\\\\\\\\\\\\\\[ d \\\\\\\\\\\\\\]\\\\\\\\\\\\\\[1,3\\\\\\\\\\\\\\]dioxolyl pyrrolidinyl pentanone. Oral , Insufflation , Intravenous, Rectal, Vaporization. Contents 1 Appearance 2 Pharmacology 3 Effects 3. See also Sympathomimetic amines.

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