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It is a member of the quinazolinone class. The sedative—hypnotic activity of methaqualone was first noted by researchers in the s. In , methaqualone was patented in the US by Wallace and Tiernan. Methaqualone became increasingly popular as a recreational drug and club drug in the late s and s, known variously as 'ludes' or 'sopers' also 'soaps' in the U. Methaqualone is a sedative that increases the activity of the GABA receptors in the brain and nervous system. When GABA activity is increased, blood pressure drops and the breathing and pulse rates slow, leading to a state of deep relaxation. These properties explain why methaqualone was originally mainly prescribed for insomnia. Regular users build up a physical tolerance, requiring larger doses for the same effect. Overdose can lead to nervous system shutdown, coma and death. Methaqualone is not recommended for use while pregnant and is in pregnancy category D. An overdose can cause delirium , convulsions , hypertonia , hyperreflexia , vomiting , kidney failure , coma , and death through cardiac or respiratory arrest. It resembles barbiturate poisoning, but with increased motor difficulties and a lower incidence of cardiac or respiratory depression. Urine drug test of gas-liquid chromatography GLC confirmation up to 90 hours after the last intake is a practical way of detecting methaqualone use. Information provided by government, industrial, and academic sources most notably quoted in the textbook 'Illegal Drugs' Gahlinger, and some more in depth media reports list diphenhydramine and ostensibly other ethanolamine antihistamines as a potential source of methaqualone false-positives on immunoassay drug tests. Whether quinine and its relatives also have the potential to cause false positives is not known. In , it was the sixth-bestselling sedative in the US, \\\\\\\\\\\\\[12\\\\\\\\\\\\\] where it was legal under the brand name Quaalude. Quaalude in the United States was originally manufactured in by the Fort Washington, Pennsylvania, based pharmaceutical firm William H. The drug name 'Quaalude' combined the words 'quiet interlude' and shared a stylistic reference to another drug marketed by the firm, Maalox. Lemmon also marketed a small quantity under another name, Mequin, so doctors could prescribe the drug without the negative connotations. Later, headlines were focused on Quaaludes after a deposition became public where Bill Cosby admitted under oath that he had given the drug to women with whom he wanted to have sex. As mentioned above, methaqualone is a common recreational and self-medication drug in South Africa and other of the former Frontline States , including Mozambique, Angola, Zambia and Zimbabwe. The methaqualone and MDMA, along with cocaine and other empathogens and aphrodisiacs as well as muscle relaxants and incapacitating anticholinergic deliriants were considered for non-lethal riot-control use. The total methaqualone cache may have approached a ton. North, Central, and South American clandestine drug markets typically source the drug from industrial-scale illegal drug labs in Mexico, Colombia, Belize, Peru and elsewhere. Smaller labs occasionally are uncovered in the United States and Canada and the final percentage of methaqualone as well as mecloqualone, other chemical relatives, other congeners, and unreacted precursors form a chemical profile which can be used as a fingerprint to identify the likely origin of batches of the drug just as such things as morphine content and its relation to heroin content and presence of codeine, acetylcodeine, noscapine, papaverine, and other opium components form a chemical fingerprint for batches of heroin. Methaqualone became increasingly popular as a recreational drug in the late s and s, known variously as 'ludes' or 'sopers' also 'soaps' in the U. It was withdrawn from many developed markets in the early s. In the United States it was withdrawn in and made a Schedule I drug in Mention of its possible use in some types of cancer and AIDS has periodically appeared in the literature since the late s; research does not appear to have reached an advanced stage. Methaqualone was also manufactured in the US under the trade names Sopor and Parest. After the legal manufacture of the drug ended in the United States in , underground laboratories in Mexico continued illegal manufacture of methaqualone all through the s, continuing the use of the '' stamp, until their popularity waned in the early s. Purported methaqualone is in a significant minority of cases found to be inert, or contain diphenhydramine or benzodiazepines. Methaqualone is one of the most commonly used recreational drugs in South Africa. From Wikipedia, the free encyclopedia. D Evidence of risk. Winter Music First ed. Little, Brown and Company. Archived from the original on February 23, Retrieved 15 August Image hurt by street use'. Retrieved 16 August Synthesis of substituted 4-quinazolones, I. Accessed 9 July Archived from the original on Glutethimide Methyprylon Pyrithyldione Piperidione. Serotonin antagonists and reuptake inhibitors Etoperidone Nefazodone Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramine , etc. Tetracyclic antidepressants Mianserin Mirtazapine , etc. Typical antipsychotics Chlorpromazine Thioridazine , etc. Atypical antipsychotics Olanzapine Quetiapine Risperidone , etc. Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramine , etc. Agomelatine Melatonin Ramelteon Tasimelteon. Gabapentin Gabapentin enacarbil Mirogabalin Phenibut Pregabalin. GABA A receptor positive modulators. Glutethimide Methyprylon Piperidione Pyrithyldione. Retrieved from ' https: Views Read Edit View history. In other projects Wikimedia Commons. This page was last edited on 30 October , at By using this site, you agree to the Terms of Use and Privacy Policy. 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