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Methadone is a narcotic that works by changing the way the brain and nervous system respond to pain. Methadone carries a black-box warning because it may cause serious or life-threatening breathing problems. The risk of breathing problems is highest during the first 72 hours of treatment and any time your dose is increased. You should tell your doctor if you have or have ever had asthma , slowed breathing, chronic obstructive pulmonary disease COPD , or any other type of lung disease; a head injury; any condition that increases pressure in your brain; or obstructive or central sleep apnea. Also, you should watch for any signs of breathing problems, including slowed breathing, long pauses between breaths, or shortness of breath. This medication may also cause a rare heart problem known as a long QT interval. This condition can cause irregular heartbeat, fainting, or sudden death. You should tell your doctor if you or anyone in your family has or has ever had long QT syndrome. Also, tell your healthcare provider if you have ever had a slow or irregular heartbeat, heart disease, or low levels of potassium or magnesium in your blood. Call your doctor right away if you experience a pounding heartbeat, lightheadedness, dizziness, or fainting while taking methadone. Tell your physician you are taking methadone before having any type of surgery, including dental procedures. Talk to your doctor before you stop using methadone. However, this is an extremely dangerous practice and can lead to overdose and death. You should never take more methadone than your doctor prescribes. Methadone may be habit-forming. Do not take larger doses of methadone or take it for a longer period of time than your doctor prescribes. You should tell your physician if you or anyone in your family has a history of drinking large amounts of alcohol, using street drugs, or having any type of mental illness. Store methadone in a safe place, so no one else can take it. Keep this drug out of the reach of children. You doctor will likely want to decrease your dose gradually before taking you off this drug. Methadone might harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while taking this medicine. Your baby may also develop life-threatening withdrawal symptoms after birth if you take methadone during pregnancy. Methadone can pass into breast milk and may harm a breastfeeding baby, so talk to your doctor before breastfeeding while taking this medication. You should call your doctor immediately or seek emergency medical help if you experience any of the following severe side effects:. You should also tell your doctor if you are taking or have stopped taking a monoamine oxidase inhibitor MAOI in the past 14 days. These include isocarboxazid Marplan , phenelzine Nardil , selegiline Eldepryl, Emsam, Zelapar , and tranylcypromine Parnate. Consuming alcohol or other drugs that contain alcohol may increase serious side effects of methadone. You should talk to your doctor about this potential interaction, or avoid all grapefruit products while taking methadone. Methadone comes as a tablet, a dispersible tablet, a liquid, a concentrated solution, or an injection. Your dose of methadone may range from 2. You should take methadone exactly as your doctor prescribes. Your physician might change your dose during the course of your treatment. If your doctor tells you to take only part of a tablet, be sure to break it carefully along the score lines. You should drink the entire mixture right away. If some tablet residue gets left behind in the cup, you can add a small amount of liquid and drink it. If you miss a dose of methadone for treating an opioid addiction, skip the missed dose and take it the next day as scheduled. A: Methadone has the side effect of weight loss and loss of appetite. However, other side effects may occur. If you notice any abnormal weight changes, then you should contact your health care provider. A: According to the available drug information for methadone, weight gain is not reported as a side effect. If you are experiencing unexplained weight gain, with no changes in diet or activity level, you may want to contact your health care provider. A: Methadone, according to prescribing information, can cause lightheadedness as a side effect of the medication. Methadone is slowly eliminated from the body, so you may not have experienced any side effects at the beginning of the reduction of this medication. If your side effects are bothersome or severe, you should consult with your physician to be sure that you are not reducing the medication too quickly. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. A: Methadone is a narcotic analgesic pain reliever that is similar to morphine. It also helps to reduce withdrawal symptoms in people addicted to heroin or other narcotic drugs without causing the 'high' associated with the drug addiction. So, methadone can be used as a pain reliever and as part of drug addiction detoxification and maintenance programs. Loss of appetite can be a common side effect of methadone. Other side effects that may commonly occur include anxiety, nervousness, restlessness, insomnia, weakness, drowsiness, dry mouth, nausea, vomiting, diarrhea, constipation, and decreased sex drive. This is not a complete list of side effects that can occur with methadone. If side effects, such as weight loss or loss of appetite, become severe or bothersome, talk to your doctor for specific recommendations. Your doctor or health care provider is best able to properly evaluate your medical condition and make recommendations based on your specific circumstances. Sarah Lewis, PharmD. A: Dolophine methadone is a medication used to treat pain and to help treat opiate addiction. It does not specifically list twitching or jumping as side effects, but if you think you may be having some kind of seizure, you should consult your doctor about it. The time it takes to stop is very individualized, and depends on if it is being used for pain or addiction. Side effects from Dolophine methadone may include seizures, hives, rash, and itching, in which case, you should let your doctor know as soon as possible. Other side effects listed are drowsiness, weakness, headache, nausea, vomiting, constipation, loss of appetite, weight gain, stomach pain, dry mouth, sweating, flushing, difficulty urinating, swelling of the hands, feet, arms, and legs, changes in mood, insomnia, changes in vision, sexual impairment, and missing menstrual periods. This is not a complete list of the side effects associated with Dolophine methadone. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Always keep a current list of the drugs and supplements you take and review it with your healthcare providers and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. Tell your health-care provider about any negative side effects from prescription drugs. You can also report them to the U. Food and Drug Administration by visiting www. Patti Brown, PharmD. A: Methadone is a narcotic analgesic or pain reliever that is similar to morphine. It can also reduce withdrawal symptoms in people addicted to heroin or other narcotic drugs without causing the 'high' associated with the drug addiction. This makes it easier to manage the addiction and helps to get the person off narcotics. Methadone can be used either as a pain reliever or as part of drug addiction detoxification and maintenance programs. Methadone may be habit-forming, meaning that it is possible to become physically or mentally dependent on the drug. So, it should never be stopped suddenly, as this may cause serious withdrawal side effects. Contact your doctor before stopping methadone. It can also cause side effects that impair your thinking and reactions. Use caution when doing anything that requires alertness. Common side effects of methadone include anxiety, nervousness, restlessness, insomnia, weakness, drowsiness, dry mouth, nausea, vomiting, diarrhea, constipation, loss of appetite, and decreased sex drive. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications, particularly before taking any action. Sarah Lewis, RPh. A: Methadone is in a drug class called opiate or narcotic analgesics. Methadone is used to treat moderate to severe pain that has not been effectively treated by non-narcotic pain medications. In addition, methadone is used as part of a treatment program to help people who were addicted to opiate medications. Methadone helps these people stop taking the medications or to help them avoid restarting the medications. Methadone prevents withdrawal symptoms from happening in people who were addicted to opiate medications. Methadone works to relieve pain by altering the way in which the brain and nervous system respond to pain. Methadone works to prevent withdrawal symptoms by acting like a substitute for opiate medications and producing similar effects. According to prescribing information, the most common side effects with methadone are lightheadedness, dizziness, sedation, nausea, vomiting, and sweating. These side effects occur more often in people who are not hospitalized and who are not experiencing severe pain. Other side effects include weakness, headache, constipation, itching, and dry mouth. Methadone can also cause breathing problems that can cause death. These problems are more likely to occur when methadone is first started or in people who were not taking other opioid pain medications. Breathing problems may not necessarily occur right after a dose is taken? Methadone can also cause heartbeat problems that can be fatal. Most of these heartbeat problems occur in people using high doses of methadone to treat pain; however, some heartbeat problems have been reported in people using smaller doses for opioid drug addiction. People taking methadone should contact their doctor if they: have difficulty breathing; become very drowsy and breathing slows down; have little movement of the chest with breathing; have a fast or slowed heartbeat; feel faint, extremely dizzy, confused, have irregular heartbeats or any other symptoms that are not typical. Methadone can also cause a drop in blood pressure, which can cause dizziness when getting up too fast from sitting or lying down. Methadone can cause tolerance the need for elevated doses to maintain efficacy that are not caused by disease progression or other factors and physical dependence, which is the occurrence of withdrawal symptoms after abruptly stopping the medication. Thus, methadone should not be stopped without first consulting with the doctor. In general methadone should be gradually discontinued to avoid becoming sick with withdrawal symptoms. According to prescribing information, for people taking methadone for the treatment of pain, there is a chance of addiction or abuse. Drug addiction manifests as compulsive use, use for purposes other than medical use, and continuing to use despite the risk of harm or actual harm. People have a higher chance of addiction or abuse if they are or have been addicted to or abused other medications, street drugs, or alcohol, or if they have a history of mental problems. Derek Dore, PharmD. A: Methadone is a narcotic analgesic or pain reliever, similar to morphine. It reduces withdrawal symptoms in people addicted to heroin or other narcotic drugs without causing the 'high' associated with the drug addiction. Common side effects that can occur with methadone include anxiety, nervousness, restlessness, insomnia, weakness, drowsiness, dry mouth, nausea, vomiting, diarrhea, constipation, loss of appetite, and decreased sex drive. Consult your doctor or healthcare if constipation continues or becomes bothersome. There are a variety of over-the-counter OTC treatments for mild constipation. These include stool softeners, fiber products, laxatives, enemas, and suppositories. The choice depends largely on personal preference and how uncomfortable the constipation is. There are also lifestyle changes that help, including eating fiber-rich foods, drinking plenty of water, and getting regular exercise. Always read and follow the complete directions and warnings on OTC medications and discuss their use with your healthcare provider before taking them. Consult your healthcare provider for severe or persistent constipation, as this could be a sign of an underlying medical condition. A: Methadose methadone is a narcotic pain reliever similar to morphine. Methadone is prescribed for pain and also drug addiction detoxification. Common side effects with methadone include sedation, nausea, dizziness, and lightheadedness. This is not a complete list of side effects associated with methadone, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Dosing of methadone is usually patient specific so consult with your doctor about your particular situation. When your doctor prescribes a new medication, be sure to discuss all your prescription medications and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals and herbals, as well as foods you eat. If possible, use one pharmacy for all your prescriptions and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and advise you about drug interactions and side effects. Kimberly Hotz, PharmD. Methadone can also reduce withdrawal symptoms in people addicted to heroin or other narcotic drugs without causing the 'high' associated with the drug addiction. It can be used as a pain reliever or as part of drug addiction detoxification and maintenance programs. Weight gain can also be a common side effect of methadone. However, a search of a drug database did not specifically list dry skin as a side effect. Edema or fluid build-up can occur with methadone. If you are experiencing swelling or fluid retention or buildup, contact your doctor for proper evaluation. Your doctor is best able to evaluate your medical condition, including side effects, and make recommendations for managing them based on your specific circumstances. Do not stop or change the amount of medication you take without talking to your doctor first. A: Methadone is a narcotic pain reliever used in the treatment of many chronic pain conditions. Methadone can cause weight loss or weight gain in some patients. The FDA approved drug information lists both weight gain and anorexia as possible side effects of methadone. The most common side effects of methadone are: constipation, drowsiness, dizziness, dry mouth, headache, itching, sweating, lightheadedness, nausea, vomiting, and weakness. Do not stop taking methadone abruptly, as severe withdrawal symptoms may occur. The only way to gain weight is to increase caloric intake. Eating more fruits, vegetables, and whole grains is a healthy way to put on weight. Eating sweets, fried foods, fast food, and junk food may help you gain weight, but these foods will also increase your risk of diabetes, high blood pressure, and heart disease. One easy way to increase caloric intake is to add a nutritional supplement such as Boost, Ensure, etc. People who are severely underweight may need to supplement their diet with several of these products every day. You should consult your physician or a nutritionist for more detailed information about adding a nutritional supplement to your diet. Burton Dunaway, PharmD. A: Methadone is a narcotic analgesic or pain reliever. Methadone can also help reduce withdrawal symptoms in people addicted to heroin or other narcotic drugs without causing the 'high' associated with the drug addiction. So, methadone can be used as a pain reliever or as part of drug addiction detoxification and maintenance programs. Methadone can cause withdrawal symptoms if it is stopped suddenly. The NIH suggests that it may not be possible for patients to become drug free. Methadone maintenance programs will be life-long therapy for most patients, but can allow patients to lead healthy lives. Often, patients using a maintenance program will want to try to taper off the methadone once their cravings have subsided and other areas of their lives are showing progress. Your doctor or health care provider is best able to guide your treatment decisions based on your specific circumstances. A: I am not privy to the nature of the ankle pain, however, methadone is not first-line therapy for ankle pain. Usually, we start with Tylenol acetaminophen and then switch or add Motrin ibuprofen. Opiates such as methadone are rarely given for bone pain, and when given, they are rarely given by themselves, usually only after several other treatments have failed. Matt Curley, PharmD. A: Methadone is a narcotic pain reliever, similar to morphine. Long-term use of narcotic pain relievers can lead to tolerance. Tolerance is the need for more medicine to achieve the same pain relief. It is different from addiction, which is when pain is under control, but the person irrationally wants more medication. Consult your health care provider to discuss concerns about long-term use. Common side effects may include feeling anxious, nervous, or restless; insomnia; feeling weak or drowsy; and dry mouth, nausea, vomiting, diarrhea, constipation, loss of appetite. Call your doctor at once if you have any of these serious side effects: shallow breathing; hallucinations or confusion; chest pain, dizziness, fainting, fast or pounding heartbeat; or trouble breathing, feeling light-headed, or fainting. A: Studies have shown that elimination of methadone is somewhat patient-specific. Usually your system can eliminate the methadone within about 72 hours in most cases. However, traces of it will still be detected in your urine for up to three weeks or longer. Methadone also is used to reduce withdrawal symptoms in people addicted to heroin or other narcotic drugs without causing the 'high' associated with the drug addiction. Methadone is used as a pain reliever and as part of drug addiction detoxification and maintenance programs. Methadone can be taken with or without food but exactly as prescribed. Other side effects with methadone include abdominal pain, loss of appetite, constipation, dry mouth and tongue swelling. Methadone may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Methadone with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Do not drink alcohol or use medicines that may cause drowsiness Methadone dosing is usually highly individualized. The complexities associated with Methadone dosing can contribute to cases of overdose. A high degree of opioid tolerance dose not eliminated the possibility of Methadone overdose. Consult with your healthcare provider if the Methadone is not adequately controlling the pain. Do not take more medication or abruptly stop a medication without first consulting with the healthcare provider. Your doctor may be able to give guidance on an appropriate pain therapy. Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. You can browse Drugs A-Z for a specific prescription or over-the-counter drug or look up drugs based on your specific condition. This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis. Remember to always consult your physician or health care provider before starting, stopping, or altering a treatment or health care regimen. Every effort has been made to ensure that the information provided by on this page is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. The information on this page has been compiled for use by healthcare practitioners and consumers in the United States and therefore neither Everyday Health or its licensor warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Neither Everyday Health nor its licensors endorse drugs, diagnose patients or recommend therapy. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. Neither Everyday Health nor its licensor assume any responsibility for any aspect of healthcare administered with the aid of the information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have any questions about the drugs you are taking, check with your doctor, nurse or pharmacist. What Is Methadone Dolophine? Methadone Side Effects. Methadone Interactions. Methadone Dosage. Methadone 5 mg-ROX, white, round,. Methadone 10 mg-ROX, white, round,. Dolophine 5 mg-ROX, white, round,. Methadose 5 mg, white, round,. Q: Does taking methadone for pain from three spinal surgeries cause me to gain weight? I have gained since I started taking it. Is this normal? Q: Can Methadone cause twitching or jumping when going to sleep at night? Also, I would like to ask how long does someone have to take Methadone if they are on 80 ml a day? Q: What are the side effects of methadone when taken for pain? What are the chances someone can get addicted to it when taken for a long time? Q: Does methadone cause serious problems with constipation? Q: Someone in severe pain taking methadone for 4 yrs. What would the maintenance dose be? Q: Does methadone causes weight gain, dry skin, and fluid buildup in the legs and body? If so, what can you do to not gain weight. Q: Does methadone cause weight loss, and how can I gain the weight back? Q: Should methadone be given for ankle pain? Q: What are the side effects of taking methadone daily for pain long term? Q: How long will it take to get methadone out of my system when I slowly detox and never take it again? Q: What is the maximum daily dose of methadone? Read Next Methadone Reviews.

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Methadone may be habit forming. Take methadone exactly as directed. Do not take a larger dose, take it more often, or take it for a longer period of time or in a different way than prescribed by your doctor. While taking methadone, discuss with your healthcare provider your pain treatment goals, length of treatment, and other ways to manage your pain. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications, or if you have or have ever had depression or another mental illness. There is a greater risk that you will overuse methadone if you have or have ever had any of these conditions. Talk to your healthcare provider immediately and ask for guidance if you think that you have an opioid addiction or call the U. Methadone may cause serious or life-threatening breathing problems, especially during the first 24 to 72 hours of your treatment and any time your dose is increased. Your doctor will monitor you carefully during your treatment. Tell your doctor if you have or have ever had slowed breathing or asthma. Your doctor will probably tell you not to take methadone. Also tell your doctor if you have or have ever had lung disease such as chronic obstructive pulmonary disease COPD; a group of lung diseases that includes chronic bronchitis and emphysema , a head injury, or any condition that increases the amount of pressure in your brain. The risk that you will develop breathing problems may be higher if you are an older adult or are weak or malnourished due to disease. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment: slowed breathing, long pauses between breaths, or shortness of breath. Taking certain other medications during your treatment with methadone may increase the risk that you will experience serious, life-threatening side effects such as breathing problems, sedation, or coma. Tell your doctor if you are taking or plan to take any of the following medications: antipsychotics such as aripiprazole Abilify , asenapine Saphris , cariprazine Vraylar , chlorpromazine, clozapine Versacloz , fluphenazine, haloperidol Haldol , iloperidone Fanapt , loxapine, lurasidone Latuda , molindone, olanzapine Zyprexa , paliperidone Invega , perphenazine, pimavanserin Nuplazid , quetiapine Seroquel , risperidone Risperdal , thioridazine, thiothixene, trifluoperazine, and ziprasidone Geodon ; benzodiazepines such as alprazolam Xanax , chlordiazepoxide Librium , clonazepam Klonopin , clorazepate Gen-Xene, Tranxene , diazepam Diastat, Valium , estazolam, flurazepam, lorazepam Ativan , oxazepam, temazepam Restoril , and triazolam Halcion ; opiate narcotic medications for pain and cough; medications for nausea or mental illness; muscle relaxants; sedatives; sleeping pills; or tranquilizers. Your doctor may need to change the doses of your medications and will monitor you carefully. If you take methadone with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own. Drinking alcohol, taking prescription or nonprescription medications that contain alcohol, or using street drugs during your treatment with methadone increases the risk that you will experience serious, life-threatening side effects. Do not drink alcohol, take prescription or nonprescription medications that contain alcohol, or use street drugs during your treatment. Do not allow anyone else to take your medication. Methadone may harm or cause death to other people who take your medication, especially children. Store methadone in a safe place so that no one else can take it accidentally or on purpose. Be especially careful to keep methadone out of the reach of children. Keep track of how many tablets or how much liquid is left so you will know if any medication is missing. Dispose of any unwanted methadone tablets or oral solution properly according to instructions. Methadone may cause a prolonged QT interval a rare heart problem that may cause irregular heartbeat, fainting, or sudden death. Tell your doctor if you or anyone in your family has or has ever had long QT syndrome; or if you have or ever had a slow or irregular heartbeat; low blood levels of potassium or magnesium, or heart disease. If you experience any of the following symptoms, call your doctor immediately: pounding heartbeat, dizziness, lightheadedness, or fainting. Tell your doctor if you are pregnant or plan to become pregnant. If you take methadone regularly during your pregnancy, your baby may experience life-threatening withdrawal symptoms after birth. Read the information carefully and ask your doctor or pharmacist if you have any questions. If you have been addicted to an opiate narcotic drug such as heroin , and you are taking methadone to help you stop taking or continue not taking the drug, you must enroll in a treatment program. The treatment program must be approved by the state and federal governments and must treat patients according to specific federal laws. You may have to take your medication at the treatment program facility under the supervision of the program staff. Ask your doctor or the treatment program staff if you have any questions about enrolling in the program or taking or getting your medication. Methadone is used to relieve severe pain in people who are expected to need pain medication around the clock for a long time and who cannot be treated with other medications. It also is used to prevent withdrawal symptoms in patients who were addicted to opiate drugs and are enrolled in treatment programs in order to stop taking or continue not taking the drugs. Methadone is in a class of medications called opiate narcotic analgesics. Methadone works to treat pain by changing the way the brain and nervous system respond to pain. It works to treat people who were addicted to opiate drugs by producing similar effects and preventing withdrawal symptoms in people who have stopped using these drugs. Methadone comes as a tablet, a dispersible can be dissolved in liquid tablet, a solution liquid , and a concentrated solution to take by mouth. When methadone is used to relieve pain, it may be taken every 8 to 12 hours. If you take methadone as part of a treatment program, your doctor will prescribe the dosing schedule that is best for you. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand. If you are using the dispersible tablets, do not chew or swallow before mixing the tablet in a liquid. If your doctor has told you to take only part of a tablet, break the tablet carefully along the lines that have been scored into it. Drink the entire mixture right away. If some tablet residue remains in the cup after you drink the mixture, add a small amount of liquid to the cup and drink it all. Your doctor may change your dose of methadone during your treatment. Your doctor may decrease your dose or tell you to take methadone less often as your treatment continues. If you experience pain during your treatment, your doctor may increase your dose or may prescribe an additional medication to control your pain. Talk to your doctor about how you are feeling during your treatment with methadone. Do not take extra doses of methadone or take doses of methadone earlier than they are scheduled even if you experience pain. Do not stop taking methadone without talking to your doctor. Your doctor will probably want to decrease your dose gradually. If you suddenly stop taking methadone, you may experience withdrawal symptoms such as restlessness, teary eyes, runny nose, yawning, sweating, chills, muscle pain, widened pupils black circles in the middle of the eyes , irritability, anxiety, backache, joint pain, weakness, stomach cramps, difficulty falling asleep or staying asleep, nausea, decreased appetite, vomiting, or diarrhea. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine. If your doctor has told you to take methadone for pain, take the missed dose as soon as you remember it and then continue your regular dosing schedule. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are taking methadone to treat opioid addiction, skip the missed dose and take the next dose the next day as scheduled. Methadone may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication. Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture not in the bathroom. You must immediately dispose of any methadone that is outdated or no longer needed through a medicine take-back program. If you do not have a take-back program nearby or one that you can access promptly, flush any methadone tablets or solution that are outdated or no longer needed down the toilet. Talk to your pharmacist about the proper disposal of your medication. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach. In case of overdose, call the poison control helpline at While you are taking methadone, you may be told to always have a rescue medication called naloxone available e. Naloxone is used to reverse the life-threatening effects of an overdose. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood. You will probably be unable to treat yourself if you experience an opiate overdose. You should make sure that your family members, caregivers, or the people who spend time with you know how to tell if you are experiencing an overdose, how to use naloxone, and what to do until emergency medical help arrives. Your doctor or pharmacist will show you and your family members how to use the medication. If someone sees that you are experiencing symptoms of an overdose, he or she should give you your first dose of naloxone, call immediately, and stay with you and watch you closely until emergency medical help arrives. Your symptoms may return within a few minutes after you receive naloxone. If your symptoms return, the person should give you another dose of naloxone. Additional doses may be given every 2 to 3 minutes, if symptoms return before medical help arrives. Keep all appointments with your doctor or clinic. Your doctor may order certain lab tests to check your response to methadone. Before having any laboratory test especially those that involve methylene blue , tell your doctor and the laboratory personnel that you are taking methadone. This prescription is not refillable. If you continue to experience pain after you finish taking the methadone, call your doctor. If you take this medication on a regular basis, be sure to schedule appointments with your doctor so that you do not run out of medication. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies. Generic alternatives may be available. Why is this medication prescribed? How should this medicine be used? Other uses for this medicine What special precautions should I follow? What special dietary instructions should I follow? What should I do if I forget a dose? What side effects can this medication cause? What should I know about storage and disposal of this medication? Brand names. Talk to your doctor about the risks of taking methadone for your condition. Use of methadone to treat opiate addiction: If you have been addicted to an opiate narcotic drug such as heroin , and you are taking methadone to help you stop taking or continue not taking the drug, you must enroll in a treatment program. Other uses for this medicine. What special precautions should I follow? Before taking methadone, tell your doctor and pharmacist if you are allergic to methadone, any other medications, or any of the ingredients in the methadone product you plan to take. Ask your doctor or pharmacist or check the Medication Guide for a list of the ingredients. Also tell your doctor or pharmacist if you are taking or receiving the following medications or have stopped taking them in the past 14 days: monoamine oxidase MAO inhibitors including isocarboxazid Marplan , linezolid Zyvox , methylene blue, phenelzine Nardil , selegiline Eldepryl, Emsam, Zelpar , and tranylcypromine Parnate. Many other medications may also interact with methadone, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Your doctor may tell you that you should not take methadone. If you breastfeed during your treatment with methadone, your baby may receive some methadone in breastmilk. Watch your baby closely for any changes in behavior or breathing, especially when you start taking methadone. You will need to wean your baby gradually so that your baby will not develop withdrawal symptoms when he or she stops receiving methadone in breastmilk. Talk to your doctor about the risks of taking methadone. Do not drive a car or operate machinery until you know how this medication affects you. This is more common when you first start taking methadone. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. Talk to your doctor about changing your diet or using other medications to prevent or treat constipation while you are taking methadone. Methadone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: headache weight gain stomach pain dry mouth sore tongue flushing difficulty urinating mood changes vision problems difficulty falling asleep or staying asleep Some side effects can be serious. If you experience any of the following symptoms or those mentioned in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical help: seizures itching hives rash swelling of the eyes, face, mouth, tongue, or throat hoarseness difficulty breathing or swallowing extreme drowsiness agitation, hallucinations seeing things or hearing voices that do not exist , fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea nausea, vomiting, loss of appetite, weakness, or dizziness inability to get or keep an erection irregular menstruation decreased sexual desire Methadone may cause other side effects. Symptoms of overdose may include the following: small, pinpoint pupils black circles in the center of the eyes slow or shallow breathing drowsiness cool, clammy, or blue skin loss of consciousness coma limp muscles. What other information should I know? Browse Drugs and Medicines.

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