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Background: The study presents the characteristics of the use of new psychoactive substances NPS , the perceived problems experienced by users, and the reasons for cessation or cutting down. The research focused mainly on synthetic cathinones and the use of 3-MMC in Slovenia. Methods: In order to research the characteristics of NPS use, we used a questionnaire which had been developed to determine the characteristics of the use of ATS and cocaine in the context of nightlife and was elaborated in our study on the use of mephedrone. The final non-representative sample included users of NPS from Slovenia, who had completed an on-line survey over a period of 5 months in Part of the sampling was conducted on the ground and with the help of peer-groups. DrogArt's outreach workers and correspondents visited open public places, clubs, and discotheques to encourage users to participate in the survey. Most respondents included in the sample Users attributed greater risks to the use of new drugs and preferred the effects of traditional drugs to those of new drugs. The most frequently reported problems were depression The main reasons for cutting down or discontinuing the use of NPS were 'fear of the health consequences', 'actual health consequences', and 'growing weary of using'. Users experienced various problems related to the use of NPS. However, they are familiar with recommendations on harm reduction and want additional information on the harmful effects of the use of NPS. Based on the obtained results, we can develop specific interventions in the area of harm reduction. Abstract Background: The study presents the characteristics of the use of new psychoactive substances NPS , the perceived problems experienced by users, and the reasons for cessation or cutting down. Publication types Research Support, Non-U. Substances Alkaloids Illicit Drugs Psychotropic Drugs Methamphetamine cathinone 3-methylmethcathinone mephedrone methylone.

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