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His research group is interested in the pharmacological modulation of the autonomic nervous system in cardiovascular diseases. In particular, he is interested in developing 5-HT 2 receptor antagonists to protect cardiac valves lesions and other 5-HT ligands in various diseases affecting the lung, the heart and the central nervous system. He is also developing new compounds dedicated to various metabolic disorders associated with the metabolic syndrome. His research is focusing into the control of neuronal plasticity in the central nervous system and its pathological and pharmacological alterations. In particular, the team discovered that the serotonin 5-HT 2B receptor acts in the brain by increasing extracellular serotonin concentrations by a neuron control mechanism that produces serotonin, and that this receptor is involved in impulsive and depressive behaviors. They are currently working on an original concept focusing on the inflammatory origin of certain psychiatric illnesses, always focusing on serotonin. Skip to main content Skip to table of contents. Advertisement Hide. This service is more advanced with JavaScript available. Editors view affiliations Luc Maroteaux Laurent Monassier. Front Matter Pages i-viii. Pages Front Matter Pages Bone and Serotonin Receptor Type 2B. Serotonin and Cardiac Valves Degeneration in Dog. Serotonin and Fibrosis. Metabolic Regulation: Insulin Secretion and Action. Page 1 Navigate to page number of 2. About this book Introduction This contributed volume provides a comprehensive assessment of the roles played by 5-HT2B receptors in humans. These receptors have been shown to play an important role is the cardiac, intestinal, and central nervous systems as well as in bone marrow formation and growth. The molecular section includes a discussion of the genetics of 5-HT2B receptors and impulse control. The physiological section covers their role in many biological systems including the nervous system, the heart, and the lungs. Editors and affiliations. Luc Maroteaux 1 Laurent Monassier 2 1. Pharmacology Strasbourg Medical school Strasbourg France. Buy options.

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