Mechanism of receptor mediated direct penetration

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(PDF) The cell biology of receptor-mediated virus entry .
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BIOL2060: Signal Transduction Mechanisms:II Messengers and . . .
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For nonenveloped naked viruses, receptor-mediated endocytosis is used for penetration . Direct fusion: Direct fusion, as its name implies, is a mechanism in which two membranes (ie, the viral envelope and cell membrane) fuse (Fig . 3 .3A) .
In addition to endocytosis, the proposed mechanism for this group of CPPs is direct membrane transduction . Model studies have suggested that the direct transduction occurs via pore formation, carpet-like perturbations, or inverted micelles formed in the bilayer membrane . These mechanisms are described in [ 19
Key Points Virus entry into animal cells is initiated by attachment to receptors and is followed by important conformational changes of viral proteins, penetration through (non-enveloped viruses) . . .
receptor-mediated signaling can cause local actin perturbation . . . . diameter and exhibits a penetration mechanism that is currently . . . . out direct interactions with the viral glycoprotein .
Attachment to the receptor can fore the viral envelope protein to undergo either changes that result in the fusion of viral and cellular membranes, or changes of non-enveloped virus surface proteins that allow the virus to enter .
Prior to entry, a virus must attach to a host cell . Attachment is achieved when specific proteins on the viral capsid or viral envelope bind to specific proteins called receptor proteins on the cell membrane of the target cell .
www .mun .ca/biology/desmid/brian/BIOL2060/BIOL2060-14/CB14 .html
Signal transductionis defined as the ability of a cell to change behaviour in response to a receptor-ligand interaction . The ligand is the primary messenger . As the result of binding the receptor, other molecules or second messengers are produced within the target cell .
The H spikes attach to the host cell receptor site by recognising sialic acid (N-acetyl neuraminic acid), the sugar derivative of glucoprotein . Influenza neuraminidase helps the virus in penetrating the nasal and respiratory tract secretions by degrading mucosal polysaccharides . However, the receptor sites also vary from person to person .
The spike glycoprotein (S) mediates virus entry and is a primary determinant of cell tropism and pathogenesis . It is classified as a class I fusion protein, and is responsible for binding to the . . .
4 . RECEPTOR MEDIATED MECHANISM • Receptor: It is a membrane bound or intracellular macromolecular protein which is capable of binding the specific functional groups of the drug or endogenous substance .
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Mechanism of receptor mediated direct penetration

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