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MDMA the illegal drug ecstasy may provide long term benefits as a treatment for post-traumatic stress disorder, according to a study which looked at its use alongside psychotherapy. The research was a follow up to an earlier study published last year in which a group of 12 patients with chronic treatment resistant PTSD were given MDMA, and compared with another group of eight patients who were not, during and after psychotherapeutic treatment for their PTSD. The new paper , which is published in the Journal of Psychopharmacology, has followed up all but one of the original participants, up to six years after they were treated with MDMA. PTSD can be debilitating to those who suffer from it and there is a need for more effective treatment options. Some people vividly relive traumatic events in their past via uncontrollable flashbacks or nightmares; often those suffering from it will avoid anything linked to the traumatic event, which can lead to difficulties in daily life if a person was assaulted while shopping for example, they may be unable to cope in crowded places afterwards. In the original study, people were given MDMA up to a maximum of three times, and in a therapeutic setting including extended therapy sessions involving overnight stays , so short term effects of the drug could be monitored, and long term harms would be unlikely. The people recruited for the study were those who had already received conventional treatment for PTSD, which had been unsuccessful. The follow up paper shows that improvements to most of the participants in the short term persist in the longer term; at least three years after treatment. Two participants relapsed after the end of the trial, and three did not answer the questionnaire, meaning the treatment was still not completely successful for everyone. This is not unusual in treating complex mental health problems. After the end of the initial study, all participants in the placebo group were offered further therapy with MDMA, and all but one accepted, so there is no longer a comparison group. Currently, sufferers are treated with selective serotonin reuptake inhibitors SSRIs, the drugs often used to treat depression , and with psychotherapy including cognitive behavioural therapy and psychodynamic psychotherapy. While these treatments are the best available at the moment, they are not that effective. Clinical trials of psychotherapy have shown that roughly a quarter of PTSD sufferers who enrol for treatment fail to complete it, and even for those who finish their treatment, recovery is not guaranteed. Before it was made illegal, MDMA was sometimes used by psychotherapists to aid therapy sessions. People who use MDMA describe it as inducing euphoria and decreasing fear, but also report remaining clear headed and alert, unlike after using other drugs and alcohol. Psychotherapeutic techniques can involve asking patients to revisit their traumatic event in a safe environment, in order to try and eliminate the excessive reaction to the memories. In PTSD, the fear response to these memories can sometimes be so great that patients are unable to revisit them, even in the safety of a therapy session. If MDMA does reduce feelings of fear, but does not affect clear headedness, it could be a very useful tool for psychotherapists to help put patients at ease before they have to remember their trauma. But MDMA is not without harms. Short term effects of use can include hyperthermia the opposite of hypothermia; the body heats up and dehydration. Also, there is evidence although not all studies agree that long term use can have damaging effects on memory, increase depression and anxiety, and lead to liver and teeth damage. This is only a pilot study, it will need to be repeated with larger numbers of patients. But doing these kinds of studies using illegal recreational drugs can be very difficult. This study was funded by a group called the Multidisciplinary Association for Psychedelic Studies, rather than a more traditional research funding body. In the current climate of austerity and spending cuts for science, it is hard to tell whether studies that examine uses of illegal drugs are being selectively less funded, or whether all areas of science are being forced to look to more unorthodox sources for money. Medical research Psychology Neuroscience Post-traumatic stress disorder Depression news. Order by newest oldest recommendations. Show 25 25 50 All. Threads collapsed expanded unthreaded. Loading comments… Trouble loading? Trauma can be treated, but not erased Rhiannon Lucy Cosslett. Post-traumatic stress disorder sufferers need compassion, and swift, quality treatment — as I discovered myself. From ceremony to therapy: Neurologists to look at use of music to aid those suffering from post-conflict trauma. Antibiotic-resistant bacteria are a genuine threat we must all fight Heather Fairhead. Advances in medicine are in jeopardy. Doctors, governments, drug companies and patients all must change their behaviour. Soldiers more likely to be convicted of violent offences, report reveals. Podcast Science Weekly podcast: David Nutt reveals the truth about drugs. Rise of superbugs threatens antibiotic crisis.

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