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These two substances are often confused with each other, and even more often the difference between them is entirely unnoticed. The oversight is reasonable. Examining their full scientific names reveals, at a chemical level, just how similar they are. While a layperson might not notice from a single encounter the difference between MDA and MDMA, a curious explorer of psychedelics and empathogens would do well to understand the distinction between the two. MDMA was accidentally synthesized as a byproduct of a larger, unrelated effort to stop abnormal bleeding. Its psychoactive effects went unnoticed for decades. Less than a decade later, Shulgin again synthesized MDMA, this time specifically for its psychoactive effects, and shared it. Starting from a small circle of therapists, researchers, and friends, MDMA slowly trickled into the streets. Though technically these adulterated mixes are not MDMA, people sell them as such. Others try to distinguish one alias over another to signify more purity, but ultimately the confusing name-game only reveals the pervasiveness of adulterated MDMA. MDA seems to have less of the risk of adulterants, again, likely due to its relative unpopularity. These added ingredients are often the cause of many of the harmful side or after-effects. For first time users, it is advised to start with a cautious dose, and then adjust accordingly. The dosage amount and the form of the substance may affect the onset time as well. MDA tends to deliver visual distortions and even hallucinations, along with stimulant qualities like increased, focused energy. MDMA, which also offers stimulant qualities, is slightly more toned down. The strong, empathogenic feelings of social openness, increased empathy, and increased sensual pleasures are more common in MDMA. Both substances affect serotonin levels in the brain, which, at high and consistent enough exposure, can cause permanent damage. There are also risks of dehydration, vomiting, and potentially fatal cardiovascular reactions. A simple way to prevent harm from either substance is to carefully measure doses, and to space out sessions. Chemically, they are closely related, and they share many of the same associations. Often the two substances are confused for each other, and to the undiscerning, are even interchangeable. However, these substances contain significant differences in their origins, effects, and potential applications. Unfortunately, these two substances are very commonly adulterated and sold with other mixed-in substances. Your email address will not be published. Save my name, email, and website in this browser for the next time I comment. Share Tweet Share. More posts like this one. Could MDMA be the answer to all this suffering? Leave a Reply Cancel reply Your email address will not be published.
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WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. It produces long-lived entactogenic , stimulant and mild psychedelic effects that include stimulation , anxiety suppression , enhanced feelings of empathy, affection, and sociability , and euphoria when administered. MDA was first synthesized in but its psychoactive effects were not discovered until in It was used in animal and human trials between and and from to More than human subjects were given MDA in an investigation of its potential use as either an antidepressant or anorectic. By it was patented as an anorectic under the trade name 'Amphedoxamine'. Contemporary reports suggest that MDA emerged as a recreational drug towards the end of , meaning its use predates its more widely used relative MDMA Ecstasy. It also has a notably longer duration six to eight hours instead of three to five and produces more traditional serotonergic psychedelic effects such as visual distortions along with appreciably higher activity on dopamine, which is also believed to be responsible for the greater degree of neurotoxicity it produces. Today, possession of MDA is illegal in most countries, although some limited exceptions exist for scientific and medical research. MDA was originally synthesized by G. Mannish and W. Jacobson in The United States Army also experimented with the drug, code-named EA, while working to develop a truth drug or incapacitating agent. A man named Harold Blauer died in January after being intravenously injected with mg of the drug. MDA was eventually patented as a cough suppressant by H. MDA began to appear on the recreational drug scene around In early , the Bureau of Drug Abuse Control reported the seizure of over 1. MDA, also known as 3,4-methylenedioxyamphetamine, is a synthetic molecule of the amphetamine family. MDA also contains substitutions at R 3 and R 4 of the phenyl ring with oxygen groups. These oxygen groups are incorporated into a methylenedioxy ring through a methylene chain. MDA acts as a releasing agent and reuptake inhibitor of the neurotransmitters known as serotonin , dopamine and norepinephrine. While MDMA can also produce psychedelic-like visual effects, these are less pronounced than those of MDA or require a heavier dose to become apparent. It is worth noting that the role of these interactions and how they result in the psychedelic experience continues to remain elusive. Disclaimer: The effects listed below are cited from the Subjective Effect Index SEI , which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death. MDA presents an array of visual enhancements which are mild in comparison to traditional psychedelics, but still distinctively present. These generally include:. The visual geometry that is present throughout this experience can be described as more similar in appearance to that of psilocin than LSD. It can be comprehensively described through its variations as primarily intricate in complexity, abstract in form, organic in style, structured in organization, dimly lit in lighting, mostly monotone in colour with blues and greys, glossy in shading, sharp in edges, small in size, fast in speed, smooth in motion, equal in round and angular corners, non-immersive in-depth and consistent in intensity. At higher doses, they are significantly more likely to result in states of level 8A visual geometry over level 8B. At high to heavy doses, MDA is capable of producing a unique range of low and high-level hallucinatory states in a fashion that is significantly less consistent and reproducible than that of many other commonly used psychedelics. These effects are far more common during the offset of the experience and commonly include:. Anecdotal reports which describe the effects of this compound within our experience index include:. Anecdotal evidence from people within the psychonaut community who have tried MDA suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly but nothing can be completely guaranteed. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this substance. As with other stimulants , the chronic use of MDA can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Tolerance to the psychedelic effects of MDA is built almost immediately after ingestion. However, tolerance to the stimulant and entactogenic effects are built up after repeated and heavy usage in a manner that varies between individuals. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline in the absence of further consumption. MDA presents cross-tolerance with all psychedelics and most stimulants , meaning that after the consumption of MDA all psychedelics and some stimulants will have a reduced effect. Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated. Further information: Serotonergic psychedelic. Physical effects. Visual effects. Cognitive effects. Auditory effects. Transpersonal effects. After effects. Bureau of Drug Abuse Control. Feb European Journal of Pharmacology, 2—3 , — Dose-independent occurrence of seizure with tramadol. Journal of Medical Toxicology, 5 2 , Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95 4 , United Nations. Retrieved December 15, Office of Parliamentary Counsel. Government of Canada. Bundesanzeiger Verlag. Categories : CS1 German-language sources de All articles with unsourced statements Articles with unsourced statements Psychoactive substance Entactogen Stimulant Phenethylamine Amphetamine Psychedelic. Navigation menu Personal tools Create account Log in. Namespaces Page Discussion. Views Read View source View history. 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MDA vs. MDMA: Similar But Not The Same
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