Mayu Morita
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Oregon Health and Science University | OHSU · Department of Pathology
Abnormally increased angiotensin II activity related to maternal angiotensinogen (AGT) genetic variants, or aberrant receptor activation, is associated with small-for-gestational-age (SGA) babies and abnormal uterine spiral artery remodeling in humans. Our group studies a murine AGT gene titration transgenic (TG; 3-copies of the AGT gene) model, wh...
The discovery and utility of clinically relevant circulating biomarkers depend on standardized methods that minimize preanalytical errors. Here, we examined the preanalytical variations of extracellular vesicles (EVs) and cell-free mRNA (cf-mRNA) profiles in human plasma and how post-freeze/thaw processing removes and retains EVs and cf-mRNA subtyp...
Fetal growth restriction (FGR) is associated with developmental programming of adult onset hypertension, which may be related to differences in nephron development. Prior studies showed that maternal nutrient restriction is associated with reduced nephrogenesis in rodents, especially in male progeny. We hypothesized that maternal genetic risk for F...
Study question: Does the use of a vascular contrast agent facilitate earlier detection of maternal 22 flow to the placental intervillous space in the first trimester of pregnancy? 23 Summary answer: Microvascular filling of the intervillous space was demonstrated by contrast-24 enhanced ultrasound from 6 weeks of gestation onwards. 25 What is known...
Study question:
Does the use of a vascular contrast agent facilitate earlier detection of maternal flow to the placental intervillous space (IVS) in the first trimester of pregnancy?
Summary answer:
Microvascular filling of the IVS was demonstrated by contrast-enhanced ultrasound from 6 weeks of gestation onwards, earlier than previously believe...
Department of Pathology Portland, United States
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