Manufacturing Cocaine

Manufacturing Cocaine

Manufacturing Cocaine

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The leaves of Erythryoxylon coca, from which cocaine is obtained, were used by the Incas at least 1, years ago. The annual consumption of coca leaf in South America mainly Bolivia and Peru by about twenty million users amounts to about , pounds of cocaine. They chew their leaves with lime CaO, etc. Cocaine produces little effect orally, so sniffing is the preferred route of administration. Regarding its supposed aphrodisiac properties, it is interesting that one native legend ascribed the magical origin of the coca leaf to the fascination of a conqueror for the bright eyes of a princess who loved him to death. Other species of the genus seem to produce little or no cocaine. Coca-cola got its name from the coca leaf extract which it contained as did a variety of wines until Neither tolerance nor physical addiction to cocaine seem to occur, so sniffing it occasionally should be quite safe. Cocaine has structural and pharmacological similarities to the active constituents of belladonna and jimson weed and can likewise space you out in very undesirable ways, expecially if used frequently. Also, as with every drug, some people are very sensitive to it and can become paranoid, etc. Cocaine base 'free base' is much more euphorigenic than cocaine and consequently much more damaging. It seems to have the addictive pull of heroin for many users and is probably best avoided. Coca leaf contains l -ecgonine, cinnamyl cocaine and alpha and beta-truxillyl ecgonine cocamine , which can be converted to cocaine, but d-ecgonine or pseudoecgonine leads to isomers which are devoid of the strong central stimulating effects of l -cocaine. During the process of isolation from the leaf, l -cocaine is converted to ecgonine tropanbeta-ofbeta-carboxylic acid , which is easily reconverted to l -cocaine benzoylecgonine methyl ester. Cocaine can be extracted from the leaves with almost any organic solvent. Moisten the dried, powdered leaves with Na carbonate solution and extract with cold benzene or petroleum ether. Extract the organic solution with small amounts of dilute sulfuric acid and basify the extract with Na carbonate the alkaloids precipitate. Dissolve the precipitate in ether, separate the ether from the aqueous Na carbonate and dry and evaporate in vacuum the ether. Dissolve the residue in methanol and heat with sulfuric acid or methanol HCl; dilute with water and extract with CHCl3. Concentrate and neutralize the aqueous layer and cool to precipitate methylecgonine sulfate, which is converted to cocaine in one step. The alkaloids can also be extracted directly from the powder with dilute sulfuric acid. This process see Bull. Extract twice with ether, basify the aqueous solution with NH4OH and extract four times with 18 ml ether. Dry and evaporate the ether in vacuum to get cocaine. The aqueous solution contains ecgonine, which can be converted to cocaine as shown below. The zinc-mercury amalgam used for reduction here and elsewhere can be prepared as follows. Protect from moisture CaCl2 drying tube and use dry methanol. Filter and wash precipitate with 3 x 50 ml methylene chloride. If only methanol has been used, after stirring 0. Ethanol can be used in place of methanol, but add ml ether if reaction temperature rises too high, the methyldiacetyl of maleindialdehyde is produced - this can be reduced to the methyldiacetyl of succinic dialdehyde, which can be used in place of II to get IV. After absorption of 7. See below for easier methods of reducing IV. Keep pH about 3. Extract with 5 x ml CHCl3 and dry, evaporate in vacuum to get an oil. Mix the oil plus any precipitate with an equal volume of ether and filter. Add ml dry ether until no more precipitate forms, then filter test precipitate for activity - if active, this step is unnecessary and stir with activated carbon 0. Filter, wash with 1: Can purify by dissolving in methanol and washing with 1: Racemic cocaine VI is filtered off, washed with 12 ml ice water and dried over CaCl2. To get the HCl of VI , dissolve it in seven times its weight of ether containing HCl in ethanol and wash the precipitate with 1: Alternatively, mixture of 4 g V , 36 ml benzene, 1. Acidify with HCl to pH 5 and extract with 3 x 20 ml ether. For an electrolytic method of producing I see ACS 6, For NaBH4, reflux six hours in methanol. A method said to be superior to that given above for the conversion of methylecgonine to cocaine follows. Let stand two hours at room temperature and then reflux gently for 0. Evaporate in vacuum, basify with NaOH and filter to get 8. Filter, wash precipitate with benzene and dry in vacuum over KOH about two hours to get 30 g beta-ketoglutaric anhydride I. Add this solution to a solution of 10 g methylamine HCl, 4 g NaOH in ml water and stir in ml 0. This product is identical with IV of method 1 and is converted to cocaine as already described. Stir two hours at room temperature keeping air out , stir in 5 g Ba carbonate and filter. The succindialdehyde should then be extracted from the basic solution with ether and the ether dried and evaporated in vacuum. Add with stirring over 1. Keep about fifteen hours at room temperature and add to a stirred mixture of g NaHCO3, g ice and ml water. Use this in method 1 or as follows. Let stand three hours at room temperature, add 50 ml ether and refrigerate twelve hours to precipitate the dipotassium salt of monomethyl-beta-ketoglutarate II. Let stand a few hours at room temperature and proceed as in method 2. Extract with 4 x 50 ml CHCl3, dry and evaporate in vacuum and dissolve the oil in ml ether. Wash twice with a mixture of 6 ml saturated aqueous K carbonate and 3 ml 3N KOH dry and evaporate in vacuum the ether to recover unreacted tropinone. Dry and evaporate in vacuum to get an oil which is dissolved in hot acetone. Cool, add a little water and rub to start precipitation of 1. This is identical with IV of method 1, and can be recrystallized and converted to cocaine as already described. The various cocaine precursors and analogs seem not to have been tested for psychedelic activity. Cogentin benzo-tropane is hallucinogenic at a dose of about 4 mg. Synthetic compounds which may have activity are l -pseudo-cocaine, tropacocaine, eccaine, eucaine, and benzoyl-N-methyl-granatoline se BER 51, , Chem. For a simple synthesis of pseudopelletierine, which can be reduced and acylated to give active compounds, see J. For a review of tropane chemistry see Manske Ed. JCS , Acta Pharm. Suecica 7, and JMC 16, contain further information on cocaine analogs. For Cogentin synthesis see CA 47,h It may be possible to partially oxidize butanediol to butanedial succindialdehyde and distill this as the reaction occurs. The following summary of cocaine preparation and trade was prepared by the California State Attorney General in The coca plant is an evergreen, native to South America, particularly the countries of Peru, Bolivia, Brazil, Chile and Columbia, and should not be confused with the cocoa plant, from which chocolate is made. The coca plant is grown on mountain slopes or terrace uplands that have a tropical or semi-tropical climate. Actually, the plant is grown under conditions which are little suited for other crops. These mountainous areas of South America vary in altitude from 1, to 6, feet above sea level and temperatures of 68 to 86 degrees Fahrenheit. The most suitable conditions for the development of the coca plant are clay type soils, rich in humus and iron content, situated in sheltered upland valleys and exposed to constant humidity and rain precipitation. Under ideal conditions, the plant can survive, for a century or more, growing steadily in strength. In the cultivation of the coca plant, the seeds are usually taken from a plant three or more years old, placed in containers and germinated in damp sheltered nurseries. They are watered heavily for five days until they begin to swell after which they are planted in a mixture of humus sand and earth, in equal proportions, shaded and abundantly watered. After about a week and a half, the shoots begin to appear and the germinated seeds can be transplanted within 2 months. The sparsely leaved plant is usually 6 to 10 inches in height and is transplanted in the open since it has become resistant to most climatic variations. The young plant is usually planted in small trenches varying in density from 1 to 4 plants per square yard. Once the young plant has been transplanted usually in the wintertime into open fields, there is very little the cultivator does except leave the plants to themselves. Where dampness is constant and rain is regular, even irrigation is unnecessary. After approximately 1 year from the transplanting, the coca plant yields its first crop of leaves which is generally the reason the coca bush has been cultivated in the first place. The plant normally yields 4 crops of leaves per year. The coca plant is a shrub-like bush which grows from 5 to 10 feet tall with widely branched trunks containing twigs which become densely populated with leaves toward the ends. The green smooth edged leaves vary from 1 to 3 inches long and smell very similar to tea leaves. Normally, in order for the harvesting of the coca leaf to be profitable, there must be a minimum of 72, plants for every 10, square meters and the plant must last for over 30 years. Approximately 10 million coca plants produce , kilograms of coca leaf. The average coca leaf contains from 0. It is estimated that one man can harvest approximately 30 kilograms of leaves in a day. The drying process is very important and takes approximately 2 days of at least 3 hours of daily sunshine. During the process, the leaves must be turned over for even drying. If the drying is to extensive, the leaves will become too dry and lose their commercial value. The leaf is divided into 3 basic categories:. Dark green colored leaf, dried by mechanical means or by airing and pressed into bales. This form is best suited for use in export. Dark colored leaf resulting from defective drying and deliberately beat in order to meet wide demand for consumption. Leaves which as a result of neglect, dampness, delay in drying or disease, have lost some of their alkaloid content, and are of practically no commercial value. This type of coca leaf is often used as a local fertilizer. Once the leaves are dry, they are pressed and wrapped into packages of 50 or 30 kilograms. In , 1 kilogram of dried coca leaf, in Bolivia, was valued at approximately one dollar. The coca leaf is commonly chewed by the natives of South America. The natives claim that the cocaine depresses their hunger and increases their strength. The leaves are very bitter when chewed and are often flavored with another substance such as lime. The native chews, on an average, about two ounces of coca leaf daily and is often characterized by blackish red deposits on his teeth. The coca leaf is either consumed by the natives of South America or exported to other countries for consumption. Another use of the coca leaf is in the extraction of cocaine either for illegitimate or legitimate use. In , Bolivia produced an annual crop of from 12, to 18, tons of leaves although only half reached the legal market. The alkaloid cocaine is extracted from the coca leaf in basically three different chemical procedures. These procedures are used both in licit and illicit labs in the production of cocaine. According to a chemist who assisted in the legal manufacture of cocaine, there are three basic methods of extracting cocaine from the coca leaf:. The dried coca leaf is treated, through a chemical process, with an acid solution such as sulfuric acid, producing raw cocaine or coca paste. This particular process is very time consuming and can take from 1 to 2 weeks to complete. This process is used by both the legitimate and illicit manufacturers of cocaine. The dry coca leaf is treated in a chemical process with a basic solution such as sodium carbonate, producing raw cocaine. The raw cocaine is then put through another chemical process with hydrochloric acid creating a hydrochloric salt or cocaine hydrochloride. This process is less time consuming than process No. The third process is more advanced and technical than the other two procedures. The basic advantage of this process is that it gives a greater yield. The ecgonine is then treated with methyl iodide and benzoic anhydride in a chemical process creating pure cocaine. The Peruvian coca leaves, because of their richness, are commonly used in the extraction process as described in 1 or 2. When the dried coca leaves have a low cocaine content, the ecgonine process is preferred. Normally, it takes approximately pounds of dried leaves to produce one pound of cocaine. A chemist from the Federal Bureau of Narcotics and Dangerous Drugs, who was in Bolivia to observe clandestine cocaine operations, related the following step-by-step procedure for manufacturing cocaine. The method can be conveniently divided into three major steps: In general, steps 1 and 2 are carried out in 'sulfate' labs while step 3 is performed in 'crystal' labs. This solution is poured into a 'cut-out' drum containing pounds of dried coca leaves the volume of solution is just enough to cover the leaves. The mixture remains untouched the first two methods generally take one day if done by strong individuals while the third method involves a period of four days; the treatment of the leaves with an aqueous solution of potassium carbonate allows penetration of the solution into the leaves converting any cocaine salts to the free base, allowing for subsequent extraction into kerosene. The result of this is a greenish viscous liquid of about L. Water and kerosene are immiscible but apparently 'bridging' materials are extracted from the leaf which allows miscibility between the potassium carbonate solution and the kerosene; it was also explained that what we know as kerosene is also called benzin and paraffin, depending who is manufacturing the cocaine; this explanation clarified pre-existing conflicts about certain method terminology. The kerosene extract L is placed in another container and 1 L of concentrated sulfuric acid is added very slowly. A precipitate begins to come out of solution and settle to the bottom of the container apparently kerosene-insoluble cocaine sulfate and other alkaloidal sulfates are formed. The temperature of the acetone should be about C. Kerosene, which is used in great volumes in the initial extraction procedure is not controlled in Bolivia and is, in fact, used by the populace for heating their homes. It would theoretically be very easy to obtain kerosene in large quantities through pharmacies in La Paz. The inorganic reagents such as sulfuric acid, hydrochloric acid, ammonia, and potassium carbonate are not controlled. Ether and absolute alcohol, on the other hand, are controlled substances. Once the cocaine has been legally produced from the coca leaf, it is exported to various countries for medicinal use, basically as a topical local anesthetic applied to the surface, not injected, only treating a particular area. In the United States the crystalline powder is imported to pharmaceutical companies who process and package the cocaine for medical use. Merck Pharmaceutical Company and Mallinckrodt Chemical Works distribute cocaine in crystalline form Hydrochloride Salt in dark colored glass bottles to pharmacies and hospitals throughout the United States. Cocaine, in the alkaloid form base drug containing no additives such as hydrochloride in the crystalline form is rarely used for medicinal purposes. Cocaine is still a drug of choice among many physicians as a topical local anesthetic because the drug has vasoconstrictive qualities shrinks and stops the flow of blood. Synthetic local anesthetics such as novacaine and xylocaine lidocaine have also been discovered and used extensively as a local anesthetic. The illicitly manufactured cocaine from the various clandestine cocaine labs in South America, is smuggled to various countries including the United States for black market trafficking and use. Those involved in the smuggling of cocaine vary from a one man operation to organized syndicates. Often times, cocaine is first smuggled into Mexico rather than directly from South America to the United States. Cocaine, as is heroin, is usually packaged in hermetically sealed plastic bags or rubber condoms for smuggling purposes. Once the cocaine enters the US, it is then distributed through various sub-dealers down to the users. Illicit cocaine, basically, comes in three forms:. The hard tiny rock form which is readily available, especially to the large wholesaler or dealer. The flake form which is generally fairly pure cocaine which has been broken down into tiny flakes and considered a delicacy among users of cocaine. The powdered form which is usually rock or flaked cocaine diluted with other substances such as lactose or procaine. In the illicit traffic of cocaine, as in many other drugs, there is a definite channel which the drug goes through from the harvester to the user. Initially, there is the farmer who cultivates, dries and ships the coca leaf to the illicit lab. The distributor will then take the large quantity of cocaine and sell lesser amounts to a number of dealers. He may sell the cocaine in its pure form or dilute it and sell more for a lower price. Most of the traffickers keep in mind that cocaine loses its strength readily and sometimes the cutting or diluting agent will have a tendency after a period of time to begin destroying the cocaine content. When the dealers are in possesison of their 0. The cocaine street pusher will in turn, sell it to the user in gram quantities. Dilution or 'Cutting' of Cocaine The paraphernalia and diluting agents for the cutting of cocaine are very similar to those used for heroin. The process for cutting cocaine varies from individual to individual with often times the large dealer using a more elaborate process, but the basic operation is the same throughout cocaine traffic. The basic paraphernalia used is: Diluting agent, scales, measuring spoons, flat nonporous surface, razor blade, playing card or some other sharp-edged instrument, sifter or nylon stocking, funnel and packaging container such as rubber condoms, tinfoil bindles or plastic baggies. The cutting or diluting agent used for cocaine again varies with the individual and the substance that is readily available to that individual. Some of the common cutting agents for cocaine are:. Procaine which is a synthetic preparation in powder form used as a local anesthetic; Mannite, a sugar substance used as a laxative and produced in Italy; Menita, a milk sugar from Mexico and South America; Lactose or Dextrose, a white powdered milk sugar used as a baby food supplement and purchased readily in the United States in any drug store; Powdered methamphetamine also known as speed; Epsom salts; Quinine used to treat leg cramps and malaria; Powder vitamins purchased in health food stores and just about any soluble powder that is not disruptive to the body can be used, such as baking soda, powdered sugar, powdered milk, starch, etc. The dealer will either be told the percentage of cocaine by a trusted 'connection' or he will be able to approximate the percentage by various means. Some of the ways of ascertaining the approximate percentage of cocaine and the cutting agent are:. Quantitative chemical analysis which is an elaborate process requiring a qualified chemist and some elaborate laboratory equipment. Cocaine drug testing kits either manufactured for law enforcement purposes or produced by the underground. These testing kits are simply presumptive color tests. The basic color test used for cocaine is cobalt thiocyanate. The cocaine or any of the other substances from the caine family will form a brilliant blue flaky precipitate in the cobalt thiocyanate. This is an indication that the product is cocaine, procaine, tetracaine, etc. In order to determine whether there is actually any cocaine and not all procaine, stannous chloride is added to the precipitate causing all of the caines except cocaine to dissolve. If the dealer suspects that the cocaine has been cut with another caine, he can then make a partial determination as to how much of the procaine or other caine is contained in the total powder. It is alleged that the dealer can take suspected cocaine and drop it in a vial of clorox. Presumably the cocaine will dissolve completely and procaine will turn a reddish orange color with any other cut trailing to the bottom of the vial as residue. It is also alleged by the street dealers, that a determination can be made as to how much cut is in the cocaine by placing the powdered substance in a glass of water. The cocaine will dissolve almost immediately leaving the remaining cut which normally will dissolve slower and not as clear. The powdered cocaine is placed on aluminum foil and held over a low flame or match. The cocaine will burn clear. A sugar cut will darken and burn a dark brown or black therefore the larger the cut, the darker the burn. Crystallized speed or methamphetamine will pop when burned. Salts do not burn and remain as residue cuts such as procaine or quinine also burn fairly pure although it is alleged that procaine can be detected by a bubbling of the substance before it burns clear. Most common cuts do not dissolve in pure alcohol although cocaine does. Unfortunately for the dealer, procaine and methamphetamine also dissolve in pure alcohol. It is imperative that pure methanol be used since any water in the alcohol will tend to dissolve sugar and salt. Methanol can be obtained in most paint supply stores as methalated spirits. The dealer will take two equal amounts of the cocaine substance and place the equal amounts in two teaspoons next to one another. At this time, 0. The mixture is then stirred and any powder that remains is compared to the original unaltered amount in the second teaspoon to determine the percentage of the cut. If the suspected cut is procaine, the cocaine substance can be added to sodium carbonate solution. This would dissolve all the cocaine leaving just the procaine. Some dealers will test the percentage of cocaine by inhaling snorting it into the nostrils. This is probably the best and most common street test in determining the purity of the cocaine. The tester should standardize the amount snorted so that he will have the ability to distinguish. The tester will look for the swiftness of the high and the 'freeze' or numbness the substance causes. If the nasal passages burn and the eyes tear, there is a good possibility the cocaine has been cut with speed. Sugar and salt cuts will often times cause a post nasal drip. Excessive sweating and hyperactivity could mean either a speed or quinine cut was used. Excessive diarrhea would denote a laxative type cut such as epsom salts or menita. Speed tends to cause irregular bowel movement. A greater degree of numbness indicates the presence of procaine or other local anesthesia. Cocaine has a bitter taste and the addition of any cut will tend to alter that taste. A milk sugar cut will sweeten the cocaine although dextrose has a tendency to sweeten the substance more than lactose. Procaine will be bitter to the taste but will tend to numb the gums and tongue quicker and longer than cocaine. Salt has an after taste and epsom salts are a bit more sour in taste and sandy in texture. Pure cocaine crystals have a shiny almost transparent appearance and even when crushed, will retain the crystalline sparkle. The crystalline sparkle of cocaine will be dulled by most cuts. Dextrose has less dulling effect than lactose although a speed cuf usually dulls the crystals less than most other cuts. Although salts have a crystalline structure, they tend to be duller than the cocaine crystals. An alleged indication of the purity of the cocaine is the tiny rock-like material contained within the total substance. The tiny rocks are allegedly pure cocaine as they come from the manufacturer. The rock or hard substance can be felt by feeling the powdered substance. Most dealers will dilute a small portion of the cocaine and then re-test it. Most of the dealers claim that they usually only cut the amount of cocaine that will immediately be sold due to the fact that the cuts have a tendency to destroy the stability of cocaine. It is therefore advantageous to the dealer to keep the cocaine sealed in a cool place such as the refrigerator and in an amber or dark-colored jar to retain the strength of the drug as long as possible. Dealers claim that with time, moisture, warmth, air and sunlight tend to decrease the potency of the cocaine. The process for 'stepping on coke' again varies with individuals but the two basic formulas are similar to those of heroin and are as follows:. The dealer will measure out the desired amount of cocaine, for instance five level teaspoons, and place it in a pile on a flat nonporous surface such as a record album, mirror or glass plate. He will then measure out the desired amount of lactose and place it in a separate pile on the same surface. Then, using a playing card, razor blade, knife or any sharp edged instrument, the dealer chops the cocaine to take out all the lumps so the cocaine is a fairly fine powder. The cocaine is then sifted through a sifter or nylon stocking producing a fine fluffed powder and removing foreign material from the substance. Once through the sifter, the cocaine usually has a little more volume since it has been fluffed. The cocaine is sifted into a pile and the same process is repeated with the diluting agent. The dealer will then mix the pile of cocaine into the pile of diluting agent. Once this has been accomplished, he sifts the diluted cocaine through a sifter trying to get the mixture as equal as possible. The dealer may resift the diluted cocaine to assure an equally distributed mixture. The sifted cocaine is placed in a single pile. At this time, the dealer is ready to place the cocaine into packages for sale. In larger quantities, the cocaine is usually packaged in either airtight rubber condoms or plastic baggies that are also airtight. A rubber condom will usually hold from 0. It appears that most dealers prefer using the plastic baggie since it is believed that synthetic hard plastics and rubber tend to react unfavorably with cocaine in terms of chemical composition and therefore in time, decrease the potency of the cocaine. Smaller amounts or gram quantities of cocaine are usually packaged in smaller airtight clear plastic bags, paper bindles or tin foil bindles. It is very uncommon to see cocaine packaged in toy balloons the way heroin is packaged because of the action of the rubber with cocaine. Once the dealer has diluted the cocaine, he will measure out the desired amount to be packaged. This can be done by measuring it on a scale. For ounce quantities, the dealer will measure on a scale approximately 28 grams and then place this powder into a rubber condom or a plastic baggie. The dealer will then, using a rubber condom, tie a knot in the condom and possibly fold the open end back over for added protection. When using a plastic baggie, the dealer will get as much of the air out as possible and either fold the baggie over and seal it with scotch tape or use a twister to seal the end of the baggie. Another method of determining the proper amount of cocaine to be packaged is by using measuring spoons. If the dealer is going to use the most common measure of cocaine, that is a 'spoon' or approximately a gram, he will measure out a level half teaspoon and place it in the proper packaging device. When using paper bindles, the dealer will place the cocaine on the extreme inside of the paper bindle, usually a square piece of paper with 4 inches by 4 inches being a common size and drawing the two opposite ends together to form a triangle. The dealer will then begin at the base of the triangle and fold approximately 0. The outer wings of the paper bindle are then folded inside and the unfolded top of the bindle is folded and tucked into the wings. When using tin foil, the dealer will put the desired amount inside a square piece of tin foil, fold the square over into a rectangle, seal the top with a small fold and then fold the extreme ends into the inside. Once the cocaine has been packaged, it is ready to sell to either smaller dealers or to users. Seeds should be planted as soon as they fall from the bush. If they dry out, they will die right away. The only way to keep them for a maximum of about two weeks, is to keep them in moist not wet sphagnum in a cool place. Often this initiates germination, so they must be watched for rot or premature germination. Under no circumstances should they be kept dry, since even room humidity is too dry. Vermiculite seems to be the best medium for coca germination, fine grade if possible. Styrofoam cups are OK, but I prefer small plastic pots, 2'diameter, with holes in the bottom. Seeds should be planted no deeper than one inch. Pots should be raised so as not to saturate the medium. Coca, whether as a seedling or a mature plant, never likes to have wet feet. I think it is better to start them in small pots rather than flats, so there is less damage to the root system when they are transplanted. Forget the hot pad -- I think it is completely unnecessary. Seedlings usually come up in 2 to 4 weeks if they are viable. Seeds will germinate in any warm place, even if the humidity is not too great. A better idea is to place your germination pots in a terrarium with a coarse gravel layer on the bottom. Do not seal over and allow plenty of ventilation if you choose to place a layer of glass over the terrarium. Any box of this sort will do. If possible, place a Growlux fluorescent fixture, with two 40 W bulbs, over the terrarium, especially after seeds germinate. A common problem at this state is etiolation too little light which makes the plantlets weak and very susceptible to damping off, a fungus attack of the tender stems. Water the seeds when the vermiculite starts to dry out. Once a day is probably too often, unless you live in a very dry apartment. But if the drainage is good and you have plenty of holes in the bottom of the pots, excess water should drain off. Fungal attack is a real problem in a humid atmosphere and another reason for keeping the plants out of your shower, a basically unhygenic place for plants. The growlights should be about a foot above the plants. I do not recommend clay pots at this stage. They dry out too fast, especially in a dry apartment. Even in one day, a fast-drying shock can kill your plants. It is better to move into plastic pots, but the size should be increased gradually. A big pot is not necessarily good for a small plant, in fact it is not a good idea at all. From styrofoam cups, I suggest a two-inch pot, then increase inches per transplanting. It holds too much moisture and makes for saturated, unhealthy soil. I suggest the following: If this seems too light, increase loam and peat. Some sterilized organic compost, screened, may also be added for nutrition. Even when the plants are still in vermiculite, feeding with soluble plant food is recommended. They are heavy feeders and every three weeks or more often is not too often to fertilize. This element should be added about every six months, but strictly according to instructions. Soil must be flushed three times after applying the dissolved iron compound to avoid burning roots. Most yellowed or bleached out leaves are caused by iron deficiency, but this also occurs when plants go deciduous. Periodically, the whole coca bush turns yellow and drops its leaves, every one. Most people freak out when this happens, but if it is otherwise a healthy, vigorous plant, then this is normal. After dropping, new flushes soon appear to renew the foliage. This is more likely to happen with Erythroxylum coca than with E. Transplanting depends on the size of the plant and how fast it is growing. If you think your plant needs transplanting, look at the holes in the bottom of the pot to see if any roots are present. If so, then the roots have probably filled the pot and it is time. You can also carefully de-pot the plant by tapping upside down on a table edge. Repotting is probably unnecessary unless the roots have encircled the inner periphery of the pot. Again, the size of the pot should be increased gradually for best growth. Best to use rainwater, melted snow, bottled spring water or distilled water if they are available. Plants should only be watered if the soil dries out. Stick your finger in the soil. Mealy bugs are the worst offenders. Keep infested plants in quarantine. Malathion may be used as a last resort, but then leaves cannot be used until the next flush of leaves. Full sun through a window will not hurt plantlets over 3 inches tall. But no full sun outdoors until they are 3 feet tall. If plants are put out in the summer, they should be protected from sun, rain, and wind, until they are large and strong. Put them in a shady place first, under a tree, etc. Breezes are good for plants and even indoors a fan on low should be directed towards the plants. It makes them stronger. Plants can also be grown entirely under growlights, or a combination of growlights and window light. Most apartments are not sunny enough for strong growth, so especially in winter, give the plants accessory light. Growlux Widespectrum Tubes seem to work well. I use one Growlux and one regular Sylvania Lifeline tube in each fixture. They work very well. The lamps are suspended 6 inches to one foot above larger plants. Careful removal of the older leaves does not harm plants, but they should be strong and healthy to allow this, and probably three years old if grown indoors. Coca does not like extremes of any kind. Sudden temperature changes are especially damaging. Likewise, sudden changes in air humidity or soil moisture. Coca cuttings root very poorly. I have managed to root some E. It is better to fertilize your flowers and plant seed. Some varieties are self-compatible self-fertilizing. Others require two plants of different stylar lengths long styled x short styled to produce seed. This is routinely accomplished by bees and other insects in the greenhouse during the summer months and can be done with a fine artists brush at home, merely by dusting pollen from flowers on one plant to those on another with opposite stylar form. In California, outdoor cultivation of coca is possible only around San Diego, if there. Trujillo Coca would probably do well there under irrigation and intensive care. I do not subscribe to growing it commercially indoors and doubt if the produce would be worthwhile. Greenhouse and apartment grown leaf is very inferior in flavor and potency. Fresh air and sunshine are in order as with Cannabis. When plants are sprouting, it is OK to have several of them in the same pot -- a 5-inch clay pot will do for between 4 and 7 sprouts. When they reach at least two inches tall, it is good to transplant them into individual pots using the soil mixture recommended earlier. In handling the young plants, no matter how tall or short they are, always be careful not to touch the young plants or to touch them as little as possible, particularly on the roots and on the tips of the stems. The tips of the stems are where the shoots come from that allow the plant to grow, and even when the plant is mature, never touch the end of the stems and never remove the leaves that cling precariously to the end of the stem. Within a few days, little spike-shaped green sprouts will appear, and tiny, usually white, flowers. After a few years, the flowers will start producing little seedpods, roundish oval shaped green pods that the flower may still cling to. These then dry and turn slowly red on the plant, reaching a bright red like a cherry-colored coffee fruit, which contains the albumin and nourishment for the tiny seed in the center. Usually the shrubs will go through the leaf-fall several times, about once every 2 or 3 months, before the seedpods appear. Back to when the plants are still sprouts. Every day -- usually in the morning, but it depends on what fits your schedule best -once a day, flush the pots with clean water, preferably rainwater or distilled. Literally hold the whole pot without its saucer under very gently flowing water poured into the vermiculite or soil without touching the plant. The soil or medium should almost let the water drain straight through, retaining moisture but not water in the medium. This is the way to 'water' a young plant. When they get older, you can just water them regularly like any other plant, but lightly, daily. Once the plants get to be above a foot, they are pretty well established. After that first scary leaf-dropping, you will learn to recognize that process when it happens as described in Note 3 above. There is a different phenomenon that looks somewhat similar that happens to plants if they go through a sudden temperature change, especially if it gets cold suddenly or if they are exposed to cold fog and winds without much warm sunlight. In this case, the leaves very quickly become dry and crinkled and, turn deep brown and yellow-brown mottling, at first on their leaf tips and soon covering the whole leaf. This means your plant is about to die. The only thing to do is to lightly spray the leaves with pure not tap water and keep the plants at a constant warm temperature and talk to them and keep careful watch on them.

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